Results 21 to 30 of about 56,758 (233)

A comparison of cognitive functions in non-hypoxemic chronic obstructive pulmonary disease (COPD) patients and age-matched healthy volunteers using mini-mental state examination questionnaire and event-related potential, P300 analysis

Lung India, 2013
Objective: To assess sub-clinical cognitive dysfunctions in stable chronic obstructive pulmonary disease (COPD) patients having no hypoxemia vs. age-matched healthy volunteers using (i) an electrophysiological test: Auditory event related potential, P300
Prem Parkash Gupta, Sushma Sood, Atulya Atreja, Dipti Agarwal   +3 more
doaj   +1 more source

Effect of early yoga practice on post stroke cognitive impairment

Annals of Indian Academy of Neurology, 2023
Background: Post-stroke cognitive impairment (PSCI) is a clinical entity that encompasses all types of cognitive impairment following an index stroke. Yoga has been proven to have a beneficial effect not only on cardiovascular risk factors but also on ...
Manshi Kashyap, Nirendra K Rai, Ruchi Singh, Ankur Joshi, Abhijit R Rozatkar, Priyanka V Kashyap, Shweta Mishra, Sofia Mudda   +7 more
doaj   +1 more source

Combined frontal and parietal P300 amplitudes indicate compensated cognitive processing across the lifespan

Frontiers in Aging Neuroscience, 2014
In the present study the frontal and parietal P300, elicited in an auditory oddball paradigm were investigated in a large sample of healthy participants (N=1,572), aged 6-87.
Rik evan Dinteren, Rik evan Dinteren, Martijn eArns, Martijn eArns, Marijtje L.A. eJongsma, Roy P.C. eKessels, Roy P.C. eKessels   +6 more
doaj   +1 more source

Cigarette smoke extract induces the senescence of endothelial progenitor cells by upregulating p300

Tobacco Induced Diseases, 2023
Introduction Endothelial progenitor cells (EPCs) are the main source of endothelial cells. The senescence of EPCs is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).
Guibin Liang, Zhihui He, Huaihuai Peng, Menghao Zeng, Xuefeng Zhang   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Mutant and Wild-Type Tumor Suppressor p53 Induces p300 Autoacetylation

iScience, 2018
Summary: The transcriptional co-activator p300 is essential for p53 transactivation, although its precise role remains unclear. We report that p53 activates the acetyltransferase activity of p300 through the enhancement of p300 autoacetylation ...
Stephanie Kaypee, Smitha Asoka Sahadevan, Shilpa Patil, Piya Ghosh, Neeladri Sekhar Roy, Siddhartha Roy, Tapas K. Kundu   +6 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Discovery of a peptide proteolysis-targeting chimera (PROTAC) drug of p300 for prostate cancer therapyResearch in context

EBioMedicine
Summary: Background: The E1A-associated protein p300 (p300) has emerged as a promising target for cancer therapy due to its crucial role in promoting oncogenic signaling pathways in various cancers, including prostate cancer.
Dize Zhang, Bohan Ma, Donghua Liu, Wei Wu, Tianyang Zhou, Yibo Gao, Cunli Yang, Yanlin Jian, Yizeng Fan, Yuchen Qian, Jian Ma, Yang Gao, Yule Chen, Shan Xu, Lei Li   +14 more
doaj   +1 more source

USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice

Biology Direct, 2023
Background Intervertebral disc degeneration (IDD) naturally occurs during the aging process. Its occurrence is closely related to chronic inflammation; however, the causal relationship between them is controversial.
Xingguo Li, Jun Zhang, Bing Wang, Chao Chen, Enyu Zhang, Zhengpin Lv, Qicong He, Yaoquan Hu, Xuenan Wang, Fan Zhang   +9 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source