Results 31 to 40 of about 56,758 (233)
A Síndrome da Apneia Obstrutiva do Sono (SAOS) diminui as capacidades da atenção, memória e concentração, fatores relacionados com a cognição. A análise dos parâmetros do P300 auditivo permitiria inferir disfunção cognitiva.
Carlos Henrique Martins +3 more
doaj +1 more source
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu +7 more
wiley +1 more source
p300 alters keratinocyte cell growth and differentiation through regulation of p21(Waf1/CIP1).
Backgroundp300 functions as a transcriptional co-activator to regulate many cellular responses such as cell growth, transformation, development and differentiation.
Ping-Pui Wong +2 more
doaj +1 more source
This paper proposes a highly efficient ferroelectric artificial synapse device based on an oxide semiconductor and SnCl2‐inserted P(VDF‐TrFE) gate dielectric layer. This FeFET significantly improved the synaptic performance due to the ion‐dipole interaction.
Hyun‐Soo Kim +14 more
wiley +1 more source
P300 Component Modulation During a Go/Nogo Task in Healthy Children
Introduction: Several differences in the P300 component are observed when responses must be executed or inhibited in the Go/Nogo task. However, few studies were established by using well-controlled task with respect to the preparatory processing and ...
Mohammad Ali Nazari +4 more
doaj +2 more sources
Loss of p300 in proximal tubular cells reduces renal fibrosis and endothelial-mesenchymal transition
Chronic kidney disease (CKD) has a high prevalence worldwide and is typically accompanied by severe fibrosis. However, the exact pathogenesis of renal fibrosis and effective treatments have yet to be identified. In this study, we found that expression of
Hyunsik Kim +9 more
doaj +1 more source
Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer caused by the deregulation of key T-cell developmental pathways, including Notch signaling.
Luca Tottone +14 more
doaj +1 more source
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang +17 more
wiley +1 more source
p300 upregulates Ikur in atrial cardiomyocytes through activating NLRP3 inflammasome in hypertension
. Background:. The nucleotide-binding oligomerization domain [NOD-], leucine-rich repeats [LRR-], and Pyrin domain-containing protein 3 (NLRP3) inflammasome plays an essential role in hypertension-related atrial fibrillation (AF).
Long Zeng +15 more
doaj +1 more source
Deregulated expression of COX-2 has been causally linked to development, progression, and outcome of several types of human cancer. We describe a novel fundamental level of transcriptional control of COX-2 expression.
Michal Krawczyk, Beverly M Emerson
doaj +1 more source

