Results 31 to 40 of about 121,215 (251)
Oncogene, 2004 p300 and cyclic AMP response element-binding protein (CBP) are adenoviral E1A-binding proteins involved in multiple cellular processes, and function as transcriptional co-factors and histone acetyltransferases. Germline mutation of CBP results in Rubinstein-Taybi syndrome, which is characterized by an increased predisposition to childhood malignancies.
Narayanan Gopalakrishna, Iyer +2 more
openaire +2 more sources
The cost of space independence in P300-BCI spellers. [PDF]
, 2010 Background: Though non-invasive EEG-based Brain Computer Interfaces (BCI) have been researched extensively over the last two decades, most designs require control of spatial attention and/or gaze on the part of the user. Methods: In healthy adults, we
Chennu, Srivas +4 more
core +2 more sources
Lung India, 2013 Objective: To assess sub-clinical cognitive dysfunctions in stable chronic obstructive pulmonary disease (COPD) patients having no hypoxemia vs. age-matched healthy volunteers using (i) an electrophysiological test: Auditory event related potential, P300
Prem Parkash Gupta +3 more
doaj +1 more source
Cells, 2022 The paralogous lysine acetyltransferases 3 (KAT3), CBP and P300, play critical roles during neurodevelopment, but their specific roles in neural precursors maintenance and differentiation remain obscure.
Rocío González-Martínez +5 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2014 In the present study the frontal and parietal P300, elicited in an auditory oddball paradigm were investigated in a large sample of healthy participants (N=1,572), aged 6-87.
Rik evan Dinteren +6 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Mutant and Wild-Type Tumor Suppressor p53 Induces p300 Autoacetylation
iScience, 2018 Summary: The transcriptional co-activator p300 is essential for p53 transactivation, although its precise role remains unclear. We report that p53 activates the acetyltransferase activity of p300 through the enhancement of p300 autoacetylation ...
Stephanie Kaypee +6 more
doaj +1 more source
Effect of early yoga practice on post stroke cognitive impairment
Annals of Indian Academy of Neurology, 2023 Background: Post-stroke cognitive impairment (PSCI) is a clinical entity that encompasses all types of cognitive impairment following an index stroke. Yoga has been proven to have a beneficial effect not only on cardiovascular risk factors but also on ...
Manshi Kashyap +7 more
doaj +1 more source
Brain-Switches for Asynchronous Brain−Computer Interfaces: A Systematic Review [PDF]
, 2020 A brain–computer interface (BCI) has been extensively studied to develop a novel communication system for disabled people using their brain activities. An asynchronous BCI system is more realistic and practical than a synchronous BCI system, in that, BCI
Han, Chang-Hee +2 more
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source