p300-Mediated H3K18 Lactylation Drives Radiation-Induced Pulmonary Fibrosis via VIRMA-Dependent m6A Modification of GATA3. [PDF]
Adv Sci (Weinh)Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Yi J +8 more
europepmc +2 more sources
Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis. [PDF]
Adv Sci (Weinh)LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Miao Z +13 more
europepmc +2 more sources
ADP-ribosylation: An emerging regulator of the epigenome. [PDF]
Mol OncolADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Camacho CV, Liu C, Kraus WL.
europepmc +2 more sources
Neurochemical substrates and neuroanatomical generators of the event-related P300 [PDF]
, 1999 The present review focuses on the current knowledge of the neurochemical processes and neuronal structures involved in the generation of P300. The increasing knowledge in this area facilitates the physiological interpretation of P300 findings as well as ...
Bottlender, Ronald +2 more
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Abnormal P300 in people with high risk of developing psychosis [PDF]
, 2008 Background Individuals with an “at-risk mental state” (or “prodromal” symptoms) have a 20–40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone.
Day, Fern +38 more
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Asynchronous, parallel on-line classification of P300 and ERD for an efficient hybrid BCI [PDF]
, 2011 Riechmann H, Hachmeister N, Ritter H, Finke A. Asynchronous, parallel on-line classification of P300 and ERD for an efficient hybrid BCI. In: Neural Engineering (NER), 2011 5th International IEEE/EMBS Conference on.
Hachmeister, Nils ; https://orcid.org/ +3 more
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Effect of inhibition indexed by auditory P300 on transmission of visual sensory information.
PLoS ONE, 2021 Early electroencephalographic studies that focused on finding brain correlates of psychic events led to the discovery of the P300. Since then, the P300 has become the focus of many basic and clinical neuroscience studies.
Amirmahmoud Houshmand Chatroudi +3 more
doaj +1 more source
The cost of space independence in P300-BCI spellers. [PDF]
, 2013 Background: Though non-invasive EEG-based Brain Computer Interfaces (BCI) have been researched extensively over the last two decades, most designs require control of spatial attention and/or gaze on the part of the user. Methods: In healthy adults, we
Howard Bowman +11 more
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Frontiers in Immunology, 2021 The proprotein convertase enzyme FURIN promotes the proteolytic maturation of pro-proteins and thereby it serves as an important factor for maintaining cellular homeostasis.
Zsuzsanna Ortutay +6 more
doaj +1 more source
Transcriptional regulation mediated through the conjugation and deconjugation of the small ubiquitin-like modifiers SUMO-1, SUMO-2, and SUMO-3 [PDF]
, 2012 SUMO-1/2/3 are members of the ubiquitin-like family of protein modifiers. These proteins are covalently attached to numerous proteins in a directed and controlled manner.
Girdwood, David William Haxton
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