Results 181 to 190 of about 2,488,628 (260)

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, Volume 293, Issue 17, Page 5121-5139, September 2026.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

Combination of flupentixol and melitracen tablets and rTMS improves post-stroke depression through neurovegetative symptoms changes: a retrospective analysis. [PDF]

Front Neurol
Wang H, Zhang K, Yang Z, Wang Z, Cheng Y.   +4 more
europepmc   +1 more source

P53 Competitively Binds P300 to Suppress HIF‐1α/TFRC‐Mediated Ferroptosis and Promote Doxorubicin Resistance in Breast Cancer

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
Upregulated P53 competitively binds P300, reducing its availability to HIF‐1α and thereby decreasing HIF‐1α/P300 co‐occupancy and transcriptional activation at the TFRC promoter. The resulting reduction in TFRC‐dependent iron uptake weakens Fenton reactions, lipid peroxidation, and ferroptosis, ultimately promoting doxorubicin resistance in breast ...
Xiaojie Yu, Longdi Yao, Shuchun Zhang, Xiao Huang, An Xu, Deyuan Fu   +5 more
wiley   +1 more source

Task-state P300 and functional brain network abnormalities in adolescent major depressive disorder: a Stroop paradigm study. [PDF]

Front Psychiatry
Kou Y, Li J, Si Y, Zhang Y, Li W, Zhang J, Li Y, Wang J, Xiong X, Gu L, Zhang H, Wang C.   +11 more
europepmc   +1 more source

Nonlinearities and Switch‐Like Behavior in Gene Expression: From Genetics to Biochemistry and Back

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
Modest changes in transcription‐factor or chromatin‐regulator dosage can have disproportionate effects when gene‐regulatory systems operate near nonlinear thresholds. Sigmoidal input–output relationships, chromatin and cofactor recruitment, and changes in threshold position or response steepness provide molecular routes by which quantitative dosage ...
Reiner A. Veitia, James A. Birchler
wiley   +1 more source

Toward precision EEG: assessing the reliability of individual-level ERPs across EEG systems. [PDF]

Front Hum Neurosci
Korisky A, Rabinovitch E, Har-Shai Yahav P, McCandliss BD, Zion-Golumbic E.   +4 more
europepmc   +1 more source

p300-mediated histone H3K18 lactylation promotes mitochondrial ROS accumulation via mitophagy inhibition to potentiate dopamine agonists efficacy in prolactinomas. [PDF]

Redox Biol
Li S, Jiang Q, Wang Q, Li X, Wang Z, Xu L, Luo S, Wang Y, Zhang H, Shu K, Lei T, Huang Y, Lei Z.   +12 more
europepmc   +1 more source

Central Abnormalities in Idiopathic Tinnitus With Mild Hearing Loss: Selective Attention and Preprocessing Dysfunction. [PDF]

Brain Behav
Shen X, Pan H, Liu Y, Xu Z, Chen X, Liu Q, Xia K, Xie W, Wang L, Liu B, Xiao H.   +10 more
europepmc   +1 more source

A Detection Method of P300 Components Optimized for Individuals.

Japanese journal of medical electronics and biological engineering, 2002
KANOU, Naoyuki, KOBAYASHI, Yasuhiro, NAKASHIMA, Kenji, KAWAMURA, Takao   +3 more
openaire   +1 more source

Multimodal EEG-MRI Neuroimaging in Schizophrenia-A Systematic and Mechanistic Review. [PDF]

J Clin Med
Chmiel J, Kopańska M.
europepmc   +1 more source