Results 61 to 70 of about 2,488,628 (260)

Transcriptional regulation mediated through the conjugation and deconjugation of the small ubiquitin-like modifiers SUMO-1, SUMO-2, and SUMO-3 [PDF]

open access: yes, 2012
SUMO-1/2/3 are members of the ubiquitin-like family of protein modifiers. These proteins are covalently attached to numerous proteins in a directed and controlled manner.
Girdwood, David William Haxton
core   +1 more source

P300 development across the lifespan: a systematic review and meta-analysis.

open access: yesPLoS ONE, 2014
BackgroundThe P300 component of the event-related potential is a large positive waveform that can be extracted from the ongoing electroencephalogram using a two-stimuli oddball paradigm, and has been associated with cognitive information processing (e.g.
Rik van Dinteren   +3 more
doaj   +1 more source

Application of the P300 Event-Related Potential in the Diagnosis of Epilepsy Disorder: A Review

open access: yesScientia Pharmaceutica, 2018
Epilepsy is one of the most serious chronical neurological disorders, affecting more than 50 million people worldwide. It can be defined as a spectrum disorder, and patients with epilepsy possess abnormalities in cognitive functions.
Kandhasamy Sowndhararajan   +4 more
doaj   +1 more source

Extraction of the Major Features of Brain Signals using Intelligent Networks

open access: yesJournal of ICT Research and Applications, 2021
The brain-computer interface is considered one of the main tools for implementing and designing smart medical software. The analysis of brain signal data, called EEG, is one of the main tasks of smart medical diagnostic systems.
Shirin Salarian, Amir Shahab Shahabi
doaj   +1 more source

Gender effects on auditory P300: A systematic review

open access: yes, 2018
The evidence suggests that gender-related effects could influence the electrophysiological P300 parameters and stand as an additional source of variation for both clinical and non-clinical subjects. The aim of this paper is to characterize gender-related
Melynyte, Sigita   +2 more
core   +1 more source

Modulation of Lung Adenocarcinoma by Phosphorylated FOXN3‐Mediated Transcriptional Inactivation of p53

open access: yesAdvanced Science, EarlyView.
In non‐tumorous lung tissues, FOXN3 promotes the transcriptional activation of p53 by facilitating its recruitment to target promoters, thereby suppressing lung tumorigenesis through activation of the p53 signaling pathway. Conversely, in lung adenocarcinoma tissues, hyperphosphorylated FOXN3 dissociates from the promoters of p53‐responsive genes and ...
Jinjin Yu   +16 more
wiley   +1 more source

A cortical potential imaging analysis of the P300 and Novelty P3 components [PDF]

open access: yesHuman Brain Mapping, 2001
The P300 and Novelty P3 are positive components of the event related brain potential (ERP) with a latency of at least 300 ms, which are manifestations of brain activity evoked by deviant events. Spencer et al. [1999, 2001] demonstrated that these are two distinct components, both of which may be elicited, with different amplitudes, by both rare and ...
He, Bin   +4 more
openaire   +3 more sources

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

open access: yesAdvanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He   +9 more
wiley   +1 more source

Distinct Molten‐Globule Conformations in an Interacting Protein Domain Resolved by 19F NMR of Fluoroproline Residues

open access: yesAngewandte Chemie, EarlyView.
Modifying the conformational ensemble of “molten‐globule” protein by the site‐specific incorporation of stereoisomeric 4‐fluoroproline residues modulated its binding affinity and aggregation behavior. 19F NMR spectroscopy enabled the detection of key interactions responsible for structural and dynamic changes. ABSTRACT Recently, the application of deep
Abir Ben Bouzayene   +5 more
wiley   +2 more sources

MAML1 acts cooperatively with EGR1 to activate EGR1-regulated promoters: implications for nephrogenesis and the development of renal cancer.

open access: yesPLoS ONE, 2012
Mastermind-like 1 (MAML1) is a transcriptional coregulator of activators in various signaling pathways, such as Notch, p53, myocyte enhancer factor 2C (MEF2C) and beta-catenin.
Magnus L Hansson   +7 more
doaj   +1 more source

Home - About - Disclaimer - Privacy