Results 81 to 90 of about 2,488,628 (260)

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

open access: yesAdvanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi   +8 more
wiley   +1 more source

Analysis of very low frequency oscillations in electromagnetic brain signal recordings

open access: yes, 2010
Spontaneous very low frequency oscillations (<0.5 Hz), previously regarded as physiological noise, have of late been increasingly analysed in neuroimaging studies.
Demanuele, Charmaine
core   +1 more source

Components of event-related potentials and borderline personality disorder: a meta-analysis

open access: yesEuropean Journal of Psychotraumatology
Background: Borderline personality disorder (BPD) is characterized by symptoms associated with difficulties in emotion regulation, altered self-image, impulsivity, and instability in personal relationships.
Fabiola Salas   +6 more
doaj   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

open access: yesAdvanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin   +8 more
wiley   +1 more source

A model–based approach totrial–by–trial P300 amplitude fluctuations

open access: yesFrontiers in Human Neuroscience, 2013
It has long been recognized that the amplitude of the P300 component of event–related brain potentials is sensitive to the degree to which eliciting stimuli are surprising to the observers (Donchin, 1981). While Squires et al.
Antonio eKolossa   +5 more
doaj   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

open access: yesAdvanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai   +4 more
wiley   +1 more source

Cognitive Dysfunction in Chronic Rhinosinusitis: A Scoping Review

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Cognitive dysfunction is increasingly recognized as an extra‐nasal manifestation of chronic rhinosinusitis (CRS). This scoping review characterizes the primary evidence on cognition in adult CRS, covering measures, treatment response, and incident dementia.
Luke M. O'Neil   +5 more
wiley   +1 more source

An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation.

open access: yesPLoS ONE, 2012
Several human diseases including neurodegenerative disorders and cancer are associated with abnormal accumulation and aggregation of misfolded proteins. Proteins with high tendency to aggregate include the p53 gene product, TAU and alpha synuclein.
Alexander Kirilyuk   +10 more
doaj   +1 more source

The Component Structure of Event-Related Potentials in the P300 Speller Paradigm

open access: yesIEEE Transactions on Neural Systems and Rehabilitation Engineering, 2013
We investigated the componential structure of event-related potentials elicited while participants use the P300 BCI. Six healthy participants "typed" all characters in a 6 × 6 matrix twice in a random sequence. A principal component analysis indicated that in addition to the P300, target flashes elicited an earlier frontal positivity, possibly a ...
Siri-Maria, Kamp   +2 more
openaire   +2 more sources

PIN generation using EEG : a stability study [PDF]

open access: yes, 2014
In a previous study, it has been shown that brain activity, i.e. electroencephalogram (EEG) signals, can be used to generate personal identification number (PIN). The method was based on brain–computer interface (BCI) technology using a P300-based BCI
Revett, Kenneth, Palaniappan, Ramaswamy
core   +1 more source

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