Results 81 to 90 of about 2,898,090 (272)

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

A model–based approach totrial–by–trial P300 amplitude fluctuations

Frontiers in Human Neuroscience, 2013
It has long been recognized that the amplitude of the P300 component of event–related brain potentials is sensitive to the degree to which eliciting stimuli are surprising to the observers (Donchin, 1981). While Squires et al.
Antonio eKolossa, Tim eFingscheidt, Karl eWessel, Karl eWessel, Bruno eKopp, Bruno eKopp   +5 more
doaj   +1 more source

Amplitudes, latencies and correlations thereof with BCI performance shown for N200 (minimal amplitude before latency of P300 on Cz), P300 (maximum between 250 and 700 ms on Cz) and late ERP component (maximum after P300 latency on POz).

, 2013
Amplitudes, latencies and correlations thereof with BCI performance shown for N200 (minimal amplitude before latency of P300 on Cz), P300 (maximum between 250 and 700 ms on Cz) and late ERP component (maximum after P300 latency on POz).
Niels Birbaumer (36361), Wolfgang Rosenstiel (224794), Andrea Kübler (283265), Martin Bogdan (283263), Sonja Claudia Kleih (283262), Eva Maria Hammer (283259), Sebastian Halder (283257)   +6 more
core   +1 more source

Elucidating different aspects of speed of information processing: comparison of behavioral response latency and P300 latency in a modified Hick reaction time task [PDF]

, 2016
The aim of the present work was to get a more detailed understanding of the functional significance of the P300 latency. P300 latency is often used as measure of stimulus evaluation time. However, the interpretation of P300 latency as stimulus evaluation
Merks, Sarah
core   +2 more sources

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation.

PLoS ONE, 2012
Several human diseases including neurodegenerative disorders and cancer are associated with abnormal accumulation and aggregation of misfolded proteins. Proteins with high tendency to aggregate include the p53 gene product, TAU and alpha synuclein.
Alexander Kirilyuk, Mika Shimoji, Jason Catania, Geetaram Sahu, Nagarajan Pattabiraman, Antonio Giordano, Christopher Albanese, Italo Mocchetti, Jeffrey A Toretsky, Vladimir N Uversky, Maria Laura Avantaggiati   +10 more
doaj   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

The Component Structure of Event-Related Potentials in the P300 Speller Paradigm

IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2013
We investigated the componential structure of event-related potentials elicited while participants use the P300 BCI. Six healthy participants "typed" all characters in a 6 × 6 matrix twice in a random sequence. A principal component analysis indicated that in addition to the P300, target flashes elicited an earlier frontal positivity, possibly a ...
Siri-Maria, Kamp, Anthony R, Murphy, Emanuel, Donchin   +2 more
openaire   +2 more sources

Cognitive Dysfunction in Chronic Rhinosinusitis: A Scoping Review

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Cognitive dysfunction is increasingly recognized as an extra‐nasal manifestation of chronic rhinosinusitis (CRS). This scoping review characterizes the primary evidence on cognition in adult CRS, covering measures, treatment response, and incident dementia.
Luke M. O'Neil, Hannan A Qureshi, Logan Lindemann, David J. Cvancara, Ashton E. Lehmann, Aria Jafari   +5 more
wiley   +1 more source