Results 91 to 100 of about 68,762 (209)

Structural and functional insights into TBC1D17 highlight the importance of the previously uncharacterized Rab‐binding domain

Protein Science, Volume 35, Issue 5, May 2026.
Abstract TBC (Tre2/Bub2/Cdc16) domain‐containing proteins constitute the widespread family of GTPase‐activating proteins (GAPs). They interact with the Rab superfamily of small GTPases, stimulate GTP hydrolysis, and regulate vesicle trafficking. TBC1D17, involved in Shiga toxin trafficking, autophagy and glucose metabolism regulation, constitutes an ...
Dominika Nielipińska, Marta Orlikowska, Maciej Nielipiński, Bartosz Sekuła, Katarzyna M. Błażewska, Edyta Gendaszewska‐Darmach, Agnieszka J. Pietrzyk‐Brzezińska   +6 more
wiley   +1 more source

Assessing the performance of protective winter covers for outdoor marble statuary: pilot investigation [PDF]

, 2005
Outdoor statuary in gardens and parks in temperate climates has a tradition of being covered during the winter, to protect against external conditions. There has been little scientific study of the environmental protection that different types of covers ...
Berry, J, David, F, Julien-Lees, S, Stanley, B, Thickett, D   +4 more
core  

Optimal 1TEL–target protein linker character is target protein‐dependent

Acta Crystallographica Section D, Volume 82, Issue 5, Page 516-532, May 2026.
In this study, we examine the effect of short to medium‐length flexible, semi‐flexible and rigid linkers on the crystallization of a DARPin or the TNK1 UBA domain fused to the 1TEL protein crystallization chaperone, demonstrating that while rigid linkers can impair crystallization and reduce diffraction quality, the ideal linker character remains ...
Maria J. Pedroza Romo, Alihikaua Keliiliki, Jacob C. Averett, Joseph F. Gonzalez, Ethan Noakes, Elijah W. Wilson, Conrad Smith, Blake Averett, Dalton Hansen, Riley Nickles, Miles Bradford, Sara Soleimani, Tobin Smith, Supeshala Nawarathnage, Prasadika Samarwickrama, Ariel Kelsch, Derick Bunn, Cameron Stewart, Wisdom Abiodun, Evan Tsubaki, Seth Brown, Tzanko I. Doukov, James D. Moody   +22 more
wiley   +1 more source

Loan repayment behavior of beneficiary farmers in primary agricultural cooperative societies in Haryana (India)

Studia Ekonomiczne i Regionalne
The study examined the loan repayment behavior of beneficiary farmers in Primary Agricultural Cooperative Societies in the State of Haryana, India.
Singh Suninder, Singh Abhey, Rani Sumista, Rani Mamta   +3 more
doaj   +1 more source

Expression of goat poxvirus P32 protein and monoclonal antibody preparation

Frontiers in Cellular and Infection Microbiology
P32 protein serves as a crucial structural component of Goat pox virus (GTPV), which causes a highly virulent infectious disease in sheep and goats. Despite the fact that P32 has been widely expressed in the previous studies, it is difficult to obtain ...
Ying Liu, Lei Wang, Xiaoyun Chen, Xin Ma, Chunsheng Yin, Chenghuai Yang, Bo Liu, Bo Liu, Jige Du   +8 more
doaj   +1 more source

Retreatment of Direct Acting Agents (DAAs) After Initial DAA Failure in Hepatitis C Patients

Hepatology Research, Volume 56, Issue 5, Page 778-783, May 2026.
ABSTRACT Background and Aims Glecaprevir/pibrentasvir (GLE/PIB) and sofosbuvir/ledipasvir (SOF/LDV) are widely used as first‐line direct‐acting antiviral (DAA) regimens for chronic hepatitis C, achieving high virus eradication rates. However, a small proportion of patients experience treatment failure, and the optimal retreatment strategies for such ...
Nobuharu Tamaki, Masayuki Kurosaki, Hironori Ochi, Hideki Fujii, Yuichiro Suzuki, Takuya Sho, Hayato Hikita, Hiroyuki Marusawa, Yasuhiro Asahina, Namiki Izumi, Tatsuya Kanto   +10 more
wiley   +1 more source

Prevalence of Y chromosome deletions in a Brazilian population of nonobstructive azoospermic and severely oligozoospermic men

Brazilian Journal of Medical and Biological Research, 2003
We determined the prevalence of Y chromosome deletions in a population of 60 Brazilian nonobstructive azoospermic and severely oligozoospermic men. PCR-based screening of microdeletions was performed on lymphocyte DNA for the presence of 14 sequence ...
S.L. SãoPedro, R. Fraietta, D. Spaine, C.S. Porto, M. Srougi, A.P. Cedenho, M.C.W. Avellar   +6 more
doaj   +1 more source

Genetic Differentiation in the SdhC Subunit Confers Intrinsic Resistance to SDHI Fungicides in Fusarium asiaticum

Molecular Plant Pathology, Volume 27, Issue 5, May 2026.
In Fusarium asiaticum, two homologous SdhC subunits (FaSdhC1/C2) regulate sensitivity to SDHI fungicides: deletion of FaSDHC1 decreases sensitivity, while deletion of FaSDHC2 increases it. Multiple mutations in ΔFaSDHC2 confer resistance to SDHI fungicides.
Jichang Song, Jiakai Wang, Xudong Liu, Yinkai Liu, Lianyu Bi, Meixia Li, Yiqiang Cai, Mingguo Zhou, Yabing Duan   +8 more
wiley   +1 more source

The VTLISFG motif in the BH1 domain plays a significant role in regulating the degradation of Mcl-1

FEBS Open Bio, 2014
Mcl-1 is a member of the Bcl-2 family protein; its degradation is required for the initiation of apoptosis. The mechanism, however, is not yet clearly known.
Kang Xiao, Pengxuan Chen, Donald Choy Chang   +2 more
doaj   +1 more source

Plasmodium falciparum uses gC1qR/HABP1/p32 as a receptor to bind to vascular endothelium and for platelet-mediated clumping.

PLoS Pathogens, 2007
The ability of Plasmodium falciparum-infected red blood cells (IRBCs) to bind to vascular endothelium, thus enabling sequestration in vital host organs, is an important pathogenic mechanism in malaria. Adhesion of P.
Anup Kumar Biswas, Abdul Hafiz, Bhaswati Banerjee, Kwang Sik Kim, Kasturi Datta, Chetan E Chitnis   +5 more
doaj   +1 more source