Results 151 to 160 of about 737,457 (274)

The E3 Ubiquitin Ligase UBE3B Regulates Synaptic Development and Cortical Network Activity

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, abnormal social interactions, and restricted, repetitive behaviors. Pathogenic mutations in UBE3B result in neurodevelopmental disease, including intellectual disability, lack of speech, and ASD.
Shayal Vashisth, Aleya Shedd, Ariel Aiken, Solmi Cheon, Josh Bandopadhay, Kiran Kaur, Kimberly M. Huber, Maria H. Chahrour   +7 more
wiley   +1 more source

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source

From inferring preferences to enabling choice: potentials of digital tools to improve substitute decision-making. [PDF]

Front Digit Health
Funer F, Hempeler C.
europepmc   +1 more source

‘The best year’/‘I struggled with everything’: Widening participation experiences of pandemic online learning

British Educational Research Journal, EarlyView.
Abstract Improving retention and graduate outcomes for students from a widening participation (WP) background is key to achieving more equitable outcomes. However, evidence suggests WP students experienced different challenges than their peers during the COVID‐19 pandemic.
Wilhelmiina Toivo, Emily Nordmann, Jacqui Hutchison, Alison Browitt, Jill R. D. MacKay   +4 more
wiley   +1 more source

Progesterone levels on the day of the β-hCG test predict pregnancy outcomes in FET cycles. [PDF]

Sci Rep
Alpçetin SİA, Taghiyeva T, Demirdağ E, Erdem D, Akdulum MFC, Tokdemir PÇ, Bozkurt N, Erdem A, Erdem M.   +8 more
europepmc   +1 more source

‘A completely different space’: Teachers' perspectives on disadvantage, access to nature and outdoor learning

British Educational Research Journal, EarlyView.
Abstract This study examined teachers' perspectives on how children benefit from time in nature, how disadvantage shapes access and the role of schools in facilitating such access. Drawing on interviews conducted in 2022 with 25 UK primary school teachers who participated in Generation Wild, a nature connection programme for schools in economically ...
Nicola Parkin, Kersty Hobson, Wouter Poortinga, Mark Stead, Julia Newth, Jonathan Reeves, Merideth Gattis   +6 more
wiley   +1 more source

Search for marker proteins to assess blood-brain barrier development. [PDF]

Front Neuroanat
Shigemoto-Mogami Y, Nakayama-Kitamura K, Sato K.   +2 more
europepmc   +1 more source

Electroacupuncture may improve endometrial receptivity in controlled ovarian hyperstimulation mice by activating AVP neurons. [PDF]

Front Endocrinol (Lausanne)
Ma T, Li Q, Li J, Fang Y, Zan Y, Zhuang Y, Zhu Q, Xia L, Xia Y.   +8 more
europepmc   +1 more source

Advancing Sustainable Development in Manufacturing: A Strategic Framework for Overcoming Green–Lean Implementation Barriers

Business Strategy and the Environment, EarlyView.
ABSTRACT Manufacturing's transition to sustainable development depends on integrating green with lean under credible environmental policy and stakeholder engagement. Although benefits are well established, the literature underspecifies implementation barriers and their prioritisation. This study identifies, structures, and prioritises barriers to green–
Jose Arturo Garza‐Reyes, Andrew Defanto, Ranjit Roy Ghatak, Rohit Joshi, Walid al Saad   +4 more
wiley   +1 more source

Dynamic domain interactions encode possible CheA autophosphorylation mechanisms revealed by coarse-grained simulations. [PDF]

Biophys J
Huang J, Lu-Diaz KW, Thompson L, Chen J.
europepmc   +1 more source