Results 11 to 20 of about 41,041 (196)
Subunit-specific mutational analysis of residue N348 in HIV-1 reverse transcriptase [PDF]
Retrovirology, 2011 Background N348I in HIV-1 reverse transcriptase (RT) confers resistance to zidovudine (AZT) and nevirapine. Biochemical studies demonstrated that N348I indirectly increases AZT resistance by decreasing the frequency of secondary ribonuclease H (RNase H ...
Radzio Jessica, Sluis-Cremer Nicolas
doaj +5 more sources
The Development of Trait Anxiety in Nonhuman Primates During the First Year of Life. [PDF]
Dev SciABSTRACT Anxious temperament (AT) is a nonhuman primate phenotype that models childhood behavioral inhibition, a prominent risk factor for anxiety disorders and stress‐related psychopathology. To understand its earliest antecedents, we characterized AT's developmental trajectory over the first year of life.
Puralewski R +7 more
europepmc +2 more sources
Protease-mediated maturation of M-PMV reverse transcriptase into a functional heterodimer. [PDF]
Protein SciAbstract Reverse transcriptase (RT) of retroviruses orchestrates viral replication, yet its structural diversity remains poorly understood. Well‐studied RTs, such as those from HIV‐1, murine leukemia virus, and avian myeloblastosis virus, were characterized decades ago, but less prominent retroviruses have escaped detailed analysis.
Kapisheva M +6 more
europepmc +2 more sources
Quantitative Determination and Stability of Trace Levels of Oxytocin in Human and Rhesus Macaque Urine by LC-MS/MS. [PDF]
Biomed ChromatogrABSTRACT Oxytocin (OT) quantification in biological samples is vital for understanding its role in social behavior, emotion, and brain development in humans and animals. Urinary OT analysis has gained attention but is challenging due to variability in matrix effects, background interference, low concentrations, and stability concerns.
Zhang X, Fralick L, Ethun K.
europepmc +2 more sources
Sex Differences in the Effects of Etonogestrel on Respiratory Recovery in an In Vivo Rat Model of Central Chemoreflex Impairment. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim Rhythmic breathing movements driven by the brainstem rely on chemosensory inputs to homeostatically adjust motor output to the prevailing metabolic demand. The central CO2 chemoreflex is a critical component of this neural circuitry, as defects in these sensors cause hypoventilation syndromes, which are typically difficult to manage ...
Cardani S +3 more
europepmc +2 more sources
Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts [PDF]
, 2011 The transcription factor Ets-1 is known to be involved in a broad variety of cellular functions such as cell proliferation, migration, invasion, apoptosis and angiogenesis.
Edwards, Dyaln R. +6 more
core +1 more source
Retrovirology, 2010 Background The p51 subunit of the HIV-1 reverse transcriptase (RT) p66/p51 heterodimer arises from proteolytic cleavage of the RT p66 subunit C-terminal ribonuclease H (RNH) domain during virus maturation.
Parniak Michael A +2 more
doaj +1 more source
Molecules, 2020 The ongoing development of drug resistance in HIV continues to push for the need of alternative drug targets in inhibiting HIV. One such target is the Reverse transcriptase (RT) enzyme which is unique and critical in the viral life cycle—a rational ...
Kwok-Fong Chan +7 more
doaj +1 more source
New findings in cleavage sites variability across groups, subtypes and recombinants of human immunodeficiency virus type 1. [PDF]
PLoS ONE, 2014 BACKGROUND: Polymorphisms at cleavage sites (CS) can influence Gag and Pol proteins processing by the viral protease (PR), restore viral fitness and influence the virological outcome of specific antiretroviral drugs.
Esther Torrecilla +2 more
doaj +1 more source
Retrovirology, 2008 Background HIV-1 reverse transcriptase (RT) is a heterodimer composed of p66 and p51 subunits and is responsible for reverse transcription of the viral RNA genome into DNA.
Warrilow David +7 more
doaj +1 more source