Results 1 to 10 of about 17,780 (207)
Mutation and Expression of the p51 Gene in Human Lung Cancer [PDF]
Neoplasia: An International Journal for Oncology Research, 1999 A newly identified gene, p51, is a functional and structural homologue of the p53 gene and thus a candidate tumor suppressor gene. To elucidate the role of the p51 gene in lung carcinogenesis, we determined the sequences of exon-intron boundaries and the
Masachika Tani +6 more
doaj +4 more sources
Molecules, 2020 The ongoing development of drug resistance in HIV continues to push for the need of alternative drug targets in inhibiting HIV. One such target is the Reverse transcriptase (RT) enzyme which is unique and critical in the viral life cycle—a rational ...
Chinh Tran-To Su +2 more
exaly +4 more sources
Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation [PDF]
Advanced ScienceClear cell renal cell carcinoma (ccRCC) is a common and aggressive form of kidney cancer with VHL mutations present in > 50% of cases. These mutations lead to dysregulation of hypoxia‐inducible factors (HIFs) and activation of oncogenic pathways, making ...
Taowei Yang +15 more
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HER2-targeted doxorubicin-loaded cell-derived extracellular vesicles induce apoptosis of breast cancer cells via ROS/TXNIP pathway activation [PDF]
Cancer Cell InternationalBackground Systemic toxicity and limited tumor selectivity remain major obstacles in HER2-positive breast cancer therapy with conventional chemotherapeutics.
Chan Mi Lee +5 more
doaj +2 more sources
Homodimerization of the p51 Subunit of HIV-1 Reverse Transcriptase [PDF]
Biochemistry, 2010 The dimerization of HIV reverse transcriptase (RT), required to obtain the active form of the enzyme, is influenced by mutations, non-nucleoside reverse transcriptase inhibitors (NNRTIs), nucleotide substrates, Mg ions, temperature, and specifically designed dimerization inhibitors.
Geoffrey Mueller +2 more
exaly +3 more sources
The Prevalence of and Documented Indications for Antipsychotic Prescribing in Irish Nursing Homes
Pharmacy, 2021 Background: Antipsychotic medications are often used ‘off-licence’ to treat neuropsychiatric symptoms and disorders of aging and to manage behavioural and psychological symptoms of dementia despite the warnings of adverse effects. Objective: To establish
Jayne E. Kelleher +2 more
doaj +1 more source
Why Europe looks so much like China: Big government and low income inequalities
Asia and the Global Economy, 2022 One view in the literature is that the East Asian economic model is superior to other models in the Global South (i.e. in the developing world), at least in terms of catch-up development and possibly even in innovations beyond the technological frontier.
Vladimir Popov
doaj +1 more source
Using the potential of the creative economy to restore Ukraine
International Journal of Management and Economics, 2022 The concept of the creative economy in the modern global world is filled with new meanings and acquires many qualitatively new features and properties. The article describes the development of creative economy models.
Moiseienko Iryna
doaj +1 more source
Ultrafast Charge Generation Enhancement in Nanoscale Polymer Solar Cells with DIO Additive
Nanomaterials, 2020 We study the ultrafast photoexcitation dynamics in PBDTTT-C-T (P51, poly(4,8-bis(5-(2-ethylhexyl)-thiophene-2-yl)-benzo[1,2-b:4,5-b′]dithiophene-alt-alkylcarbonyl-thieno[3,4-b]thiophene)) film (~100 nm thickness) and PBDTTT-C-T:PC71BM (P51:PC71BM, phenyl-
Tongchao Shi +11 more
doaj +1 more source
P51 External Ventricular Drainage Insertion Audit [PDF]
BJS Open, 2021 Abstract Introduction External Ventricular Drainage (EVD) is a neurosurgical technique used to lower the intercranial pressure while cerebrospinal fluid (CSF) flow is obstructed. The infection rate associated with the EVD insertion in the UK is 9.3%, with ventriculitis being the most common one.
Lopuszko, Aleksandra +2 more
openaire +1 more source