Molecules, 2020 The ongoing development of drug resistance in HIV continues to push for the need of alternative drug targets in inhibiting HIV. One such target is the Reverse transcriptase (RT) enzyme which is unique and critical in the viral life cycle—a rational ...
Kwok-Fong Chan +7 more
doaj +2 more sources
P51 Neuropsychiatric lupus, two sides of the same coin
Rheumatology Advances in PracticeAbstract Introduction Neuropsychiatric lupus, a complex aspect of systemic lupus erythematosus, lacks a consistent pattern, and its classification criteria serve for research purposes which may provide an aid when assessing features but are not a formal diagnostic tool.
Hakoun, Lilase +3 more
openaire +2 more sources
P51 | DECELLULARIZATION OF HUMAN LUNG SCAFFOLD FOR TUMOR MICROENVIRONMENT MODELLING STUDY
European Journal of HistochemistryDecellularized extracellular matrix (d-ECM) is a promising biological scaffold for in vitro cancer research, due to its ability to replicate the native microenvironment and maintain key biomechanical properties1.
doaj +2 more sources
Ligand Versatility and Resistance Mechanism of Monotherapy-Grade HIV-1 Protease Inhibitor GRL-142 Binding the Multidrug Resistant Variant p51: Insights from 1 μs MD Simulations. [PDF]
J Chem Inf ModelThe emergence of HIV-1 highly resistant strains and the prevalence of HIV-associated neurocognitive disorders (HAND), are two of the biggest challenges posed to combination antiretroviral therapy (cART), despite promising advances in treatment.
Arias A +4 more
europepmc +2 more sources
Sex Differences in the Effects of Etonogestrel on Respiratory Recovery in an In Vivo Rat Model of Central Chemoreflex Impairment. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim Rhythmic breathing movements driven by the brainstem rely on chemosensory inputs to homeostatically adjust motor output to the prevailing metabolic demand. The central CO2 chemoreflex is a critical component of this neural circuitry, as defects in these sensors cause hypoventilation syndromes, which are typically difficult to manage ...
Cardani S +3 more
europepmc +2 more sources
Quantitative Determination and Stability of Trace Levels of Oxytocin in Human and Rhesus Macaque Urine by LC-MS/MS. [PDF]
Biomed ChromatogrABSTRACT Oxytocin (OT) quantification in biological samples is vital for understanding its role in social behavior, emotion, and brain development in humans and animals. Urinary OT analysis has gained attention but is challenging due to variability in matrix effects, background interference, low concentrations, and stability concerns.
Zhang X, Fralick L, Ethun K.
europepmc +2 more sources
British Journal of Surgery, 2023 Patients frequently experience symptoms after major oesophagogastric (OG) cancer resection which can delay quality of life resolution. Multiple symptoms can arise simultaneously making diagnosis of the underlying problem(s) and subsequent treatment
Sowrav Barman +10 more
semanticscholar +1 more source
P51 A national analysis of demographic features associated with spindle cell melanoma
British Journal of Dermatology, 2023 Spindle cell melanoma (SCM) is a rare morphological subtype of melanoma, characterized histologically by atypical, spindled, malignant melanocytes (Weissinger SE, Keil P, Silvers DN et al. A diagnostic algorithm to distinguish desmoplastic from spindle
Xin Wu +3 more
semanticscholar +1 more source
P51: Correlation between skin conductance and anxiety in virtual reality
International Psychogeriatrics, 2023 Despite the advantages of Virtual Reality (VR), the increase in anxiety caused by motion sickness makes it difficult to apply to patients with depression and anxiety.
Dongjun Kim +4 more
semanticscholar +1 more source
Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts [PDF]
, 2011 The transcription factor Ets-1 is known to be involved in a broad variety of cellular functions such as cell proliferation, migration, invasion, apoptosis and angiogenesis.
Edwards, Dyaln R. +6 more
core +1 more source