Retrovirology, 2010 Background The p51 subunit of the HIV-1 reverse transcriptase (RT) p66/p51 heterodimer arises from proteolytic cleavage of the RT p66 subunit C-terminal ribonuclease H (RNH) domain during virus maturation.
Parniak Michael A +2 more
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Shelterin TPP1 Promotes Hair Regeneration Through Activating Bulge Hair Follicle Stem Cells. [PDF]
Aging CellElongation of telomeres by increasing TPP1, through genetic and pharmacological approaches, promotes hair follicle bulge stem cell mobilization and migration, leading to accelerated telogen‐to‐anagen transition and hair regeneration. This work identifies TPP1 as a master regulator and therapeutic target for alopecia. ABSTRACT Telomere shortening drives
Wang L +17 more
europepmc +2 more sources
Minocycline and bone marrow-derived mononuclear cells as potential therapeutics for hereditary retinal degenerations. [PDF]
Acta OphthalmolAbstract Purpose To assess in Royal College of Surgeons (RCS) rats if the combination of two previously documented neuroprotective strategies: minocycline administration and bone marrow–derived mononuclear cells (BM‐MNCs) intravitreal transplantation, offers enhanced neuroprotection compared with each treatment alone.
Videla-Ristol A +6 more
europepmc +2 more sources
Peptides Mimicking the β7/β8 loop of HIV-1 Reverse Transcriptase p51 as “Hotspot-Targeted” Dimerization Inhibitors [PDF]
, 2020 A conformationally constrained short peptide designed to target a protein-protein interaction hotspot in HIV-1 reverse transcriptase (RT) disrupts p66-p51 interactions and paves the way to the development of novel RT dimerization ...
Corona, A. +15 more
core +2 more sources
Ligand Versatility and Resistance Mechanism of Monotherapy-Grade HIV-1 Protease Inhibitor GRL-142 Binding the Multidrug Resistant Variant p51: Insights from 1 μs MD Simulations. [PDF]
J Chem Inf ModelThe emergence of HIV-1 highly resistant strains and the prevalence of HIV-associated neurocognitive disorders (HAND), are two of the biggest challenges posed to combination antiretroviral therapy (cART), despite promising advances in treatment.
Arias A +4 more
europepmc +2 more sources
Von der Schule in den Weltraum – Experimente mit dem P51™-Fluoreszenz-Viewer [PDF]
, 2022 Fast 70 Jahre nachdem von Rosalind Franklin und ihrem Doktoranden Raymond Gosling das berühmte Foto 51, die Röntgenstruktur der DNA, aufgenommen wurde, umkreist nun „P51“ die Erde.
Block, Sarah
core +1 more source
Advances in Materials Science and Engineering, 2020 In this paper, the electromechanical behavior of lead zirconate-titanate ceramics (P51) has been characterized and modeled. The variation of the energy dissipation and peak electrical displacement of the P51 ceramic has been investigated in details.
Sheng Cang, Jiankang Chen, Chunsheng Lu
doaj +1 more source
Naše Gospodarstvo, 2022 This research is concerned with the comparative analysis of competitive trade within the cluster market economies of the European Union. The aim of this paper is to carry out trade analysis within the competing countries in the European market from 2009 ...
Adigwe Edward O.
doaj +1 more source
17-DMAG-Loaded HER2-Targeted Extracellular Vesicles Induce PARP/Caspase3-Mediated Apoptosis in Gastric Carcinoma. [PDF]
Int J Mol SciGastric cancer remains a major clinical challenge, underscoring the need for more effective drug delivery strategies. Approximately 10–20% of gastric cancers overexpress HER2, conferring aggressive tumor characteristics and poor survival, yet ...
Park SH +6 more
europepmc +2 more sources
Targeting the Structural Maturation Pathway of HIV-1 Reverse Transcriptase
Biomolecules, 2023 Formation of active HIV-1 reverse transcriptase (RT) proceeds via a structural maturation process that involves subdomain rearrangements and formation of an asymmetric p66/p66′ homodimer.
Thomas W. Kirby +6 more
doaj +1 more source