Results 61 to 70 of about 1,143 (104)

黄芪甲苷通过抑制STING通路减轻D-半乳糖诱导的心肌细胞衰老和凋亡

Zhongshan Daxue xuebao. Yixue kexue ban
目的探讨黄芪甲苷（AS-Ⅳ）对D-半乳糖（D-gal）诱导的心肌细胞衰老的保护作用及其潜在机制。方法以心肌细胞H9C2为模型，采用D-gal诱导心肌细胞衰老，通过CCK-8法检测细胞活力，β-半乳糖苷酶（SA-β-Gal）染色评估细胞衰老程度，ROS检测细胞内活性氧水平，TUNEL检测细胞凋亡程度，qRT-PCR和Western blot检测衰老相关基因和蛋白（p21、p53）及干扰素基因刺激因子（STING）通路关键基因（STING、CXCL10和 MX-1）和蛋白（STING、cGAS、p-IRF3/
郭文玉, 高佳佳, 段玮丽, 阮焕钧, 黄于朗, 王珂妹, 柯晓   +6 more
doaj  

[Identification of SORD as A Key Gene Mediating Osimertinib Primary Resistance 
in EGFR-Mutant Lung Adenocarcinoma via Machine Learning and Methylomics]. [PDF]

Zhongguo Fei Ai Za Zhi
Liang G, Wu H, Jia C, Gao P, Zhang Z, Chen C, Li Y, Liu H, Chen J.   +8 more
europepmc   +1 more source

[The clinical study of azacitidine and lenalidomide combination in myelodysplastic neoplasm patients with TP53 mutations]. [PDF]

Zhonghua Xue Ye Xue Za Zhi
Yan X, Guo CH, Yang C, Lin CQ, Song DD, Cai ZM, Wang Y, Wang L, Ge Z.   +8 more
europepmc   +1 more source

[Astragaloside IV alleviates D-GAL-induced endothelial cell senescence by promoting mitochondrial autophagy via inhibiting the PINK1/Parkin pathway]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Yi M, Luo Y, Wu L, Wu Z, Jiang C, Chen S, Ke X.   +6 more
europepmc   +1 more source

[Effect and mechanism of astaxanthin on the aging of high glucose-treated human skin fibroblasts]. [PDF]

Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi
Tang LJ, Fan LH, Wang JR, Luo M, Yang XX, Zhong RQ, Gao HY.   +6 more
europepmc   +1 more source

基于免疫组化法三阴性乳腺癌分型及其预后研究

Zhongguo shiyan zhenduanxue
目的探讨基于免疫组化法的三阴性乳腺癌（TNBC）分子分型，观察不同分子分型患者的临床病理特征及预后差异。方法根据雄激素受体（AR）、分化簇8（CD8）、叉头框蛋白C1（FOXC1）、双皮质素样激酶1(DCLK1）免疫组化表达情况进行分子分型，比较各亚型间临床、病理特征及预后差异。结果110例TNBC中腔面雄激素受体亚型35例（31.8%），免疫调节亚型24例（21.8%），基底样免疫抑制型34例（30.9%），间充质亚型17例（15.5%）。各亚型之间临床病理特征中组织学分级（P<0.001 ...
陈菊华, 阚炳华, 张宏伟, 宋琦, 陈曦, 白宁   +5 more
doaj  

[Clinical characteristics, treatment, and prognosis of double-hit multiple myeloma with concurrent 1q21+ and t (4;14)]. [PDF]

Zhonghua Xue Ye Xue Za Zhi
Guo Y, Qiao N, Tao Y, Liu KM, Ouyang HY, Liu YF, Wang Y, Zhang WP, Mi JQ.   +8 more
europepmc   +1 more source

[Role and mechanisms of FoxO3a-related signaling pathways in breast cancer cell apoptosis]. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban
Wang Z, Tang H, Shao X, Zhu Z, Li W, Chen S.   +5 more
europepmc   +1 more source

[Allogeneic hematopoietic stem cell transplantation for pediatric acute leukemia harboring the <i>PICALM-MLLT10</i> fusion in two cases]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Chen Y, Zhu YB, Zhang JS, Zhang A, Wang YQ, Hu Q, Liu AG.   +6 more
europepmc   +1 more source

[Clinical Progress and Prospects of mRNA Tumor Drugs]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Chen J, Tang X, Liu S, Guo X, Zhao C, Song X.   +5 more
europepmc   +1 more source