Results 141 to 150 of about 430,765 (317)
p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells [PDF]
, 2003 The negative-regulatory feedback loop between p53 and hdm2 forms part of a finely balanced regulatory network of proteins that controls cell cycle progression and commitment to apoptosis.
Phelps, Monika +3 more
core
Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling
Cell ReportsSummary: Tumor suppressor p53 has inherent propensities to self-associate, which can lead to oncogenic p53 aggregation. The genome caretaker 53BP1 interacts with p53, forms DNA damage-associated condensates, and has been implicated in p53 activation ...
Antonio Galarreta +5 more
doaj +1 more source
Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy
Advanced Science, EarlyView.Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li +9 more
wiley +1 more source
Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
Advanced Science, EarlyView.Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh +7 more
wiley +1 more source
Advanced Science, EarlyView.Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang +8 more
wiley +1 more source
NF-Y LOSS REACTIVATES p53 AND TRIGGERS p53-DEPENDENT APOPTOSIS IN HPV-POSITIVE HUMAN CERVICAL CARCINOMA CELLS [PDF]
, 2014 The two early HPV genes, E6 and E7, play an essential role in cellular transformation and abnormal proliferation. The oncoprotein E6 suppresses the activation of p53-dependent pathways through proteasomal degradation of p53 and inhibition of its ...
IMBRIANO, Carol +2 more
core
p53-dependent and -independent mechanisms of p53-targeting small molecules [PDF]
, 2020 Tumor suppressor p53 (Tp53) is mutated in around half of human cancers, while in wild type p53 cells its activity is continuously inhibited by MDM2 through proteasome degradation resulting in the loss of its function.
Zhu Jiawei (18636643)
core
Advanced Science, EarlyView.MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou +21 more
wiley +1 more source
Study on the Transcription Regulation of Breast Cancer Amplified Sequence 2 (BCAS2) by p53 Tumor Suppressor [PDF]
, 2010 新穎分子BCAS2已被發現在乳癌細胞株MCF7及MDA-MB-231，以及一些乳癌患者之臨床組織切片中，發現有基因放大或過度表現的的現象，並可能與乳癌細胞的侵襲性和遠端轉移有關。在本實驗室的研究中，發現默化BCAS2會導致MCF7細胞發生細胞凋亡，且細胞聚落形成能力降低。並發現BCAS2可以和抑癌蛋白p53結合，阻礙p53對下游目標基因如p21的轉錄活化，因此是一個p53的負向調控分子。53為細胞中最重要的抑癌分子之一，約有百分之五十以上的癌症被發現含有突變的p53 ...
林奕瑄, Lin, Yi-Hsuan
core
Advanced Science, EarlyView.This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu +5 more
wiley +1 more source