Results 151 to 160 of about 430,765 (317)

Regulation of cellular factors, p53 and Sp1, on Zta expression upon HDACi-induced EBV reactivation [PDF]

, 2010
在許多與EB病毒相關的疾病組織中，觀察到p53 過量累積的情形。此外，在這些病患的血清中又可偵測到較高力價的抗EB病毒溶裂期產物之抗體，因此本論文欲探討p53 對於誘導EB病毒再活化進入溶裂期過程中所扮演的角色。 在此研究中，本實驗室先前的研究，已證實在去乙醯酶抑制劑 (HDAC inhibitor)引起鼻咽癌上皮細胞株之EB病毒再活化能力的過程中，p53是重要的因子。進一步研究結果顯示，p53在促使EB病毒再活化之重要樞杻的Zta蛋白質表現過程中扮演重要角色。利用基因減弱試驗 (knockdown)
邱馨誼, Chiu, Hsin-Yi
core  

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Opto-p53: A light-controllable activation of p53 signaling pathway

Cell Structure and Function
p53 protein, a crucial transcription factor in cellular responses to a wide variety of stress, regulates multiple target genes involved in tumor suppression, senescence induction, and metabolic functions.
Tatsuki Tsuruoka, Yuhei Goto, Kazuhiro Aoki   +2 more
doaj   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

The p53 Network [PDF]

Journal of Biological Chemistry, 1998
M L, Agarwal, W R, Taylor, M V, Chernov, O B, Chernova, G R, Stark   +4 more
openaire   +2 more sources

p53 Modulates MYC-Mediated Cell Competition in Different Cancer Contexts [PDF]

, 2017
Cell competition was originally described in Drosophila as a physiological process based on the comparison of relative fitness between neighbouring cells.
SOLLAZZO, MANUELA, PESSION, ANNALISA, DI GIACOMO, SIMONE, GRIFONI, DANIELA, PAGLIA, SIMONA, DE BIASE, DARIO   +5 more
core  

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Interaction of p53 with the Δ133p53α and Δ160p53α isoforms regulates p53 conformation and transcriptional activity

Cell Death and Disease
The TP53 gene encodes p53, a transcription factor involved in tumor suppression. However, TP53 also encodes other protein isoforms, some of which can disrupt the tumor suppressor functions of p53 even in the absence of TP53 mutations.
Fanny Tomas, Pierre Roux, Véronique Gire   +2 more
doaj   +1 more source

PITAR, a DNA damage-inducible cancer/testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA

eLife
In tumors with WT p53, alternate mechanisms of p53 inactivation are reported. Here, we have identified a long noncoding RNA, PITAR (p53 Inactivating TRIM28 Associated RNA), as an inhibitor of p53.
Samarjit Jana, Mainak Mondal, Sagar Mahale, Bhavana Gupta, Kaval Reddy Prasasvi, Lekha Kandasami, Neha Jha, Abhishek Chowdhury, Vani Santosh, Chandrasekhar Kanduri, Kumaravel Somasundaram   +10 more
doaj   +1 more source