Results 191 to 200 of about 740,817 (321)

Figure S4 from Functional Profiling of p53 and RB Cell Cycle Regulatory Proficiency Suggests Mechanism-Driven Molecular Stratification in Endometrial Carcinoma [PDF]

Zelei Yang, Saie Mogre, Hyeji Jun, Ruiyang He, Sneha Ghosh Chaudhary, Upendra Raj Bhattarai, Shannan J. Ho Sui, Ursula A. Matulonis, Suzan Lazo, Aniket Shetty, Amy Cameron, Quang-Dé Nguyen, Sarah J. Hill   +12 more
openalex   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

p53 Interacts with VDAC1, Modulating Its Expression Level and Oligomeric State to Activate Apoptosis. [PDF]

Biomolecules
Gigi E, Karunanithi Nivedita A, Ben-Hail D, Santhanam M, Shteinfer-Kuzmine A, Shoshan-Barmatz V.   +5 more
europepmc   +1 more source

Modulating Purothionin Accumulation and Signal Peptide Cleavage Fine‐Tunes Wheat Flour Gluten Properties to Improve Cookie‐Making Quality

Advanced Science, EarlyView.
Dual genetic strategies for improving wheat processing quality by regulating purothionin accumulation to modulate gluten quantity and quality. The first strategy involves targeting signal peptide (SP) cleavage sites (e.g., through mutation) to indirectly reduce gluten content, thereby disrupting gluten network formation.
Yijie Liu, Siyuan Chang, Zhaoheng Zhang, Tianqi Kang, Mingde Liu, Yuan Zong, Fei Ni, Yinguang Bao, Ruijie Zhang, Xiaobang Zhang, Jinkun Du, Mingming Xin, Zhaorong Hu, Jie Liu, Zhongfu Ni, Qixin Sun, Yingyin Yao   +16 more
wiley   +1 more source

p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer. [PDF]

Redox Biol
Tong J, Han T, Deng J, Gan Y, Ruan R, Zhao W, Xiong C, Liao Q, Chen S, Bu H, Xiong J, Zhou X, Hao Q.   +12 more
europepmc   +1 more source

Supplemental Materials and Methods from Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib

Xiangyu Zeng, Fei Zhao, Jie Jia, Xianxiong Ma, Qi Jiang, Ruizhi Zhang, Chengguo Li, Tao Wang, Weizhen Liu, Yalan Hao, Kaixiong Tao, Zhenkun Lou, Peng Zhang   +12 more
openalex   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

MYLK4 promotes colorectal cancer progression by regulating lipid metabolism reprogramming via targeting ferroptosis. [PDF]

Neoplasia
Wang B, Wu K, Liu X, Shen Y, Li Y.
europepmc   +1 more source

Assessment <b></b>of Serum P53 Protein Level in Adult Patients with Acute Myeloid Leukemia in Correlation with Response to Treatment

Laith A. Jebur, Haithem Ahmed Al-Rubaie
openalex   +2 more sources

Wee1 inhibition can suppress tumor proliferation and sensitize p53 mutant colonic cancer cells to the anticancer effect of irinotecan

, 2017
Yunping Yin, Qian Shen, Ruikang Tao, Weilong Chang, Ruidong Li, Gengchen Xie, Weizhen Liu, Peng Zhang, Kaixiong Tao   +8 more
openalex   +2 more sources