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Liver injury in a preclinical model of short bowel syndrome is associated with impaired autophagy. [PDF]

open access: yesSci Rep
Alligood DM   +11 more
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Interaction Domains of p62: A Bridge Between p62 and Selective Autophagy

DNA and Cell Biology, 2013
p62 is a multidomain protein that contains different kinds of protein-protein interaction domains, including an N-terminal PB1 domain, a ZZ-type zinc finger domain, a nuclear localization signal (NLS), an export motif (NES), the LC3-interacting region (LIR), the KEAP1-interacting region (KIR), and a C-terminal Ub-associated domain (UBA).
Xiaolong, Lin   +6 more
openaire   +2 more sources

Sequestosome 1/p62: across diseases

Biomarkers, 2012
Sequestosome 1/p62 is a signal modulator or adaptor protein involved in receptor-mediated signal transduction. Sequestosome 1/p62 is gaining attention as it is involved in several diseases including Parkinson disease, Alzheimer disease, liver and breast cancer, Paget's disease of bone, obesity and insulin resistance.
Thangiah, Geetha   +3 more
openaire   +2 more sources

Presenilin-1 Regulates the Expression of p62 to Govern p62-dependent Tau Degradation

Molecular Neurobiology, 2013
Mutations in presenilin-1 (PS1) are tightly associated with early-onset familial Alzheimer's disease (FAD), which is characterized by extracellular amyloid plaques and the accumulation of intracellular Tau. In addition to being the catalytic subunit of γ-secretase, PS1 has been shown to regulate diverse cellular functions independent of its proteolytic
Ying-Tsen, Tung   +6 more
openaire   +2 more sources

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