Astaxanthin Inhibits p70 S6 Kinase 1 Activity to Sensitize Insulin Signaling [PDF]
Marine Drugs, 2020 Astaxanthin (AST) is a carotenoid with therapeutic values on hyperglycemia and diabetic complications. The mechanisms of action of AST remain incompletely understood.
Chunmei Li +4 more
doaj +8 more sources
Inhibition of mTOR signaling by genetic removal of p70 S6 kinase 1 increases anxiety-like behavior in mice [PDF]
Translational Psychiatry, 2021 The mechanistic target of rapamycin (mTOR) is a ubiquitously expressed kinase that acts through two complexes, mTORC1 and mTORC2, to regulate protein homeostasis, as well as long lasting forms of synaptic and behavioral plasticity. Alteration of the mTOR
Muriel Koehl +4 more
doaj +8 more sources
Interactions between sleep disruption, motor learning, and p70 S6 kinase 1 signaling. [PDF]
Sleep, 2020 Offline gains in motor performance after initial motor learning likely depend on sleep, but the molecular mechanisms by which this occurs are understudied.
Kam K +10 more
europepmc +6 more sources
Activation of a novel p70 S6 kinase 1-dependent intracellular cascade in the basolateral nucleus of the amygdala is required for the acquisition of extinction memory. [PDF]
Mol Psychiatry, 2018 Repeated presentations of a previously conditioned stimulus lead to a new form of learning known as extinction, which temporarily alters the response to the original stimulus.
Huynh TN +10 more
europepmc +7 more sources
TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1. [PDF]
Sci Rep, 2013 There is growing interest in identifying regulators of autophagy. The molecular mechanism underlying transforming growth factor-β activated kinase 1 (TAK1)-induced autophagy is poorly understood.
Shin JH +6 more
europepmc +8 more sources
Resveratrol attenuates doxorubicin-induced cardiomyocyte death via inhibition of p70 S6 kinase 1-mediated autophagy. [PDF]
J Pharmacol Exp Ther, 2012 Resveratrol is a plant-derived polyphenol that can attenuate the cardiotoxic effects of doxorubicin (DOX), a powerful antibiotic widely used in cancer chemotherapy. However, the underlying protective mechanisms of resveratrol remain elusive. Here, we show that resveratrol inhibited DOX-induced autophagy and cardiomyocyte death, and autophagy ...
Xu X +4 more
europepmc +7 more sources
Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis. [PDF]
Cell Metab, 2008 p70 S6 kinase 1 (S6K) is a major downstream effector of the mammalian target of rapamycin (mTOR), primarily implicated in the control of protein synthesis, cell growth, and proliferation. Here we demonstrate that specific bidirectional molecular targeting of mediobasal hypothalamic (MBH) S6K activity in rats is sufficient to significantly alter food ...
Blouet C, Ono H, Schwartz GJ.
europepmc +8 more sources
Targeting Translation Control with p70 S6 Kinase 1 Inhibitors to Reverse Phenotypes in Fragile X Syndrome Mice. [PDF]
Neuropsychopharmacology, 2016 Aberrant neuronal translation is implicated in the etiology of numerous brain disorders. Although mTORC1-p70 ribosomal S6 kinase 1 (S6K1) signaling is critical for translational control, pharmacological manipulation in vivo has targeted exclusively mTORC1 due to the paucity of specific inhibitors to S6K1.
Bhattacharya A +7 more
europepmc +7 more sources
Targeting 3-phosphoinoside-dependent kinase-1 to inhibit insulin-like growth factor-I induced AKT and p70 S6 kinase activation in breast cancer cells. [PDF]
PLoS ONE, 2012 Binding of IGF to IGF-IR activates PI3K to generate PIP3 which in turn recruits and activates proteins that contain a pleckstrin homology (PH) domain, including AKT and PDK1.
Sangita M Baxi +4 more
doaj +6 more sources
Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice. [PDF]
Neuron, 2012 Fragile X syndrome (FXS) is the leading inherited cause of autism and intellectual disability. Aberrant synaptic translation has been implicated in the etiology of FXS, but most lines of research on therapeutic strategies have targeted protein synthesis indirectly, far upstream of the translation machinery.
Bhattacharya A +5 more
europepmc +8 more sources