Astaxanthin Inhibits p70 S6 Kinase 1 Activity to Sensitize Insulin Signaling [PDF]
Marine Drugs, 2020 Astaxanthin (AST) is a carotenoid with therapeutic values on hyperglycemia and diabetic complications. The mechanisms of action of AST remain incompletely understood.
Chunmei Li +4 more
doaj +5 more sources
Inhibition of mTOR signaling by genetic removal of p70 S6 kinase 1 increases anxiety-like behavior in mice [PDF]
Translational Psychiatry, 2021 The mechanistic target of rapamycin (mTOR) is a ubiquitously expressed kinase that acts through two complexes, mTORC1 and mTORC2, to regulate protein homeostasis, as well as long lasting forms of synaptic and behavioral plasticity. Alteration of the mTOR
Muriel Koehl +4 more
doaj +7 more sources
Possible involvement of p60-S6K1 in accelerating RPS6 phosphorylation for rapid recovery from skeletal muscle disuse atrophy [PDF]
Laboratory Animal ResearchBackground Stroke-prone spontaneously hypertensive rats (SHRSP) exhibit slow-twitch muscle-specific hypotrophy compared with normotensive Wistar-Kyoto rats (WKY).
Takao Inoue +10 more
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Constitutive activation of the Src-family kinases Fgr and Hck enhances the tumor burden of acute myeloid leukemia cells in immunocompromised mice [PDF]
Scientific ReportsOverexpression of the myeloid Src-family kinases Fgr and Hck has been linked to the development of acute myeloid leukemia (AML). Here we characterized the contribution of active forms of these kinases to AML cell cytokine dependence, inhibitor ...
Sherry T. Shu +3 more
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p60-S6K1 represents a novel kinase active isoform with the mode of regulation distinct from p70/p85-S6K1 isoforms [PDF]
The Ukrainian Biochemical Journal, 2019 The phosphatidylinositol-3-kinase (PI3K)/mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway controls plenty of cellular functions regulating phosphorylation one of its mediators ribosomal protein S6 kinase 1 (S6K1).
I. V. Zaiets +4 more
doaj +1 more source
The Journal of Poultry Science, 2022 Protein synthesis in skeletal muscle is considered one of the most energy-consuming cellular processes. AMP-activated protein kinase (AMPK) is a metabolic master switch that regulates glucose and lipid metabolism, and it is implicated in protein ...
Kazuki Nakashima, Aiko Ishida
doaj +1 more source
Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1 [PDF]
, 2012 Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 protein stability in response to mitogenic stimuli, which resulted from p70S6K1 ...
Bajer, Magdalena M. +11 more
core +10 more sources
Molecular Characterization and Expression Analysis of S6K1 in Cashmere Goats () [PDF]
Asian-Australasian Journal of Animal Sciences, 2013 p70 ribosomal S6 kinase (p70S6K) can integrate nutrient and growth factor signals to promote cell growth and survival. We report our molecular characterization of the complementary DNA (cDNA) that encodes the goat p70S6K gene 40S ribosomal S6 kinase 1 ...
Wu Manlin +5 more
doaj +1 more source
PF-4708671 activates AMPK independently of p70S6K1 inhibition. [PDF]
PLoS ONE, 2014 The P70 ribosomal protein S6 kinase 1 (P70S6K1) is activated by the mammalian target of rapamycin (mTORC1) and regulates proliferation, growth, and metabolism.
Gilad W Vainer +5 more
doaj +1 more source
Differential expression and biochemical activity of the immune receptor Tim-3 in healthy and malignant human myeloid cells [PDF]
, 2015 The T cell immunoglobulin and mucin domain 3 (Tim-3) is a plasma membrane-associated receptor which is involved in a variety of biological responses in human immune cells.
Bardelli, Marco +4 more
core +6 more sources