Results 91 to 100 of about 24,655 (236)

Integrative Genomic and Transcriptomic Analysis Reveals Targetable Vulnerabilities in Angioimmunoblastic T‐Cell Lymphoma

American Journal of Hematology, Volume 100, Issue 9, Page 1486-1501, September 2025.
ABSTRACT Nodal follicular helper T‐cell (T FH) lymphoma of the angioimmunoblastic (AITL) subtype has a dismal prognosis. Using whole‐exome sequencing (n = 124), transcriptomic (n = 78), and methylation (n = 40) analysis, we identified recurrent mutations in known epigenetic drivers (TET2, DNMT3A, IDH2 R172 ) and novel ones (TET3, KMT2D).
Alyssa Bouska, Weiwei Zhang, Sunandini Sharma, Harald Holte, Rauf A. Shah, Waseem G. Lone, Mahfuza Afroz Soma, Ruimeng Yang, Xuxiang Liu, Syed Mehmood, Ravneet Singh Chawla, Luca Vincenzo Cappelli, Danilo Fiore, Qiang Gong, Tayla B. Heavican‐Foral, Jeffrey J. Cannatella, Catalina Amador, Aiza Arif, Lynette M. Smith, Soon Thye Lim, Choon Kiat Ong, Andrew L. Feldman, Ming‐Qing Du, Anamarija M. Perry, Laurence de Leval, Timothy C. Greiner, Kai Fu, Gunhild Trøen, Daniel Vodák, Sigve Nakken, Jan Delabie, David Weinstock, Stefano Pileri, Antonella Laginestra, KyeongJin Kim, Utpal Pajvani, Julie M. Vose, Dennis D. Weisenburger, Steven M. Horwitz, Sandeep Dave, Joseph Khoury, Giorgio Inghirami, Wing C. Chan, Javeed Iqbal   +43 more
wiley   +1 more source

Translational Inhibition of Slug by Pdcd4 Contributes to Invasion Inhibition in Colorectal Cancer Cells [PDF]

Cancer Med
ABSTRACT Background Colorectal cancer (CRC) metastasis remains a major cause of mortality, driven by epithelial‐to‐mesenchymal transition (EMT) and invasion. Programmed cell death 4 (Pdcd4), a tumor suppressor, is known to inhibit translation via interaction with eukaryotic initiation factor 4A (eIF4A).
Wang Q, He W, Han S, Li M, Wang Y, Zaytseva Y, Chen L, Zhu J, Yang H.   +8 more
europepmc   +2 more sources

A preexisting rare PIK3CA e545k subpopulation confers clinical resistance to MEK plus CDK4/6 inhibition in NRAS melanoma and is dependent on S6K1 signaling [PDF]

, 2018
Combined MEK and CDK4/6 inhibition (MEKi + CDK4i) has shown promising clinical outcomes in patients with NRAS- mutant melanoma. Here, we interrogated longitudinal biopsies from a patient who initially responded to MEKi + CDK4i therapy but subsequently ...
Amaria, Rodabe N., Aplin, Andrew A., Carapeto, Fernando C.L., Chen, Merry, Chen, Pei-Ling, Davies, Michael A., Duose, Dzifa Y., Futreal, P. Andrew, Kwong, Lawrence N., Lazar, Alexander J., Li, Jun, Liang, Roger J., Liu, Mingguang, McQuade, Jennifer L., Roh, Whijae, Romano, Gabriele, Song, Ping, Teh, Jessica L.F., Wargo, Jennifer A., Zhang, David Y., Zhang, Jianhua   +20 more
core   +1 more source

Recessive nephrocerebellar syndrome on the Galloway-Mowat syndrome spectrum is caused by homozygous protein-truncating mutations of WDR73. [PDF]

, 2015
We describe a novel nephrocerebellar syndrome on the Galloway-Mowat syndrome spectrum among 30 children (ages 1.0 to 28 years) from diverse Amish demes.
Al Turki, S, Baple, E, Campellone, K, Chioza, BA, Crino, P, Crosby, A, Cross, H, Fogo, AB, Harding, B, Harlalka, GV, Heaps, AD, Hildebrandt, F, Hurles, ME, Jinks, RN, Koehler, AE, Maroofian, R, McGlincy, MH, Morton, DH, Morton, MC, Provencher, MM, Puffenberger, EG, Sadowski, CE, Smith, JD, Stempak, L, Strauss, KA, Tran, L, Wang, H, Wenger, O, Xin, B, Zaritsky, J   +29 more
core   +1 more source

Transforming Growth Factor‐Beta Signaling in Cancer: Therapeutic Implications, Challenges, and Pathways to Progress

MedComm – Oncology, Volume 4, Issue 3, September 2025.
TGF‐β inhibition is emerging as a promising cancer therapy, yet translating laboratory success to bedside implementation has suffered significant setbacks. The associated challenges include adverse drug reactions, inadequate predictive models, and activation of alternative signaling pathways.
Faizah A. Alabi, Izuchukwu F. Okpalanwaka, Adenike Oyegbesan, Ebenezar Okoyeocha, Mariam Oladejo, Sikiru O. Imodoye   +5 more
wiley   +1 more source

Short-term low-protein diet during pregnancy alters islet area and protein content of phosphatidylinositol 3-kinase pathway in rats

Anais da Academia Brasileira de Ciências, 2015
The phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways mediate β cell growth, proliferation, survival and death. We investigated whether protein restriction during pregnancy alters islet morphometry or the expression and ...
CRISTIANA S.B. SALVATIERRA, SÍLVIA R.L. REIS, ANA F.M. PESSOA, LETÍCIA M.I. DE SOUZA, LUIZ F. STOPPIGLIA, ROBERTO V. VELOSO, MARISE A.B. REIS, EVERARDO M. CARNEIRO, ANTONIO C. BOSCHERO, EDSON M. COLODEL, VANESSA C. ARANTES, MÁRCIA Q. LATORRACA   +11 more
doaj   +1 more source

TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis. [PDF]

, 2014
In addition to regulating the activation of nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK), TGF-β activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy.
Seki, Ekihiro
core   +2 more sources

mTORC1 Targets the Translational Repressor 4E-BP2, but Not S6 Kinase 1/2, to Regulate Neural Stem Cell Self-Renewal In Vivo

Cell Reports, 2013
The mammalian target of rapamycin complex 1 (mTORC1) integrates signals important for cell growth, and its dysregulation in neural stem cells (NSCs) is implicated in several neurological disorders associated with abnormal neurogenesis and brain size ...
Nathaniel W. Hartman, Tiffany V. Lin, Longbo Zhang, Grace E. Paquelet, David M. Feliciano, Angélique Bordey   +5 more
doaj   +1 more source

Die Phosphorylierung von Plakophilin3 durch die p70-S6-Kinase und ihr Einfluss auf Funktion und Lokalisation [PDF]

, 2017
Ziel der vorliegenden Arbeit war es, zu untersuchen, ob eine Interaktion zwischen Plakophilin3 und der p70-S6-Kinase stattfindet und mögliche Auswirkungen auf die Funktion von Plakophilin3 zu untersuchen.
Möllmer, Marius-Claudius
core   +1 more source

Exogenous Nucleotides Supplementation Attenuates Age‐Related Sarcopenia

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 4, August 2025.
ABSTRACT Background Sarcopenia, an age‐related clinical syndrome characterized by reduced skeletal muscle mass and strength, often leads to a loss of physical function. Nucleotides (NTs) supplementation is a potential strategy for preventing age‐related sarcopenia as evidence suggests that NTs declined in muscles with aging, and 5′‐CMP, 5′‐UMP can ...
Xin Wu, Rui Liu, Na Zhu, Xiujuan Wang, Chan Wei, Xiaoyang An, Meihong Xu, Yong Li   +7 more
wiley   +1 more source