Results 91 to 100 of about 20,664 (187)

Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase [PDF]

, 2001
Background: The p70 S6 kinase, like several other AGC family kinases, requires for activation the concurrent phosphorylation of a site on its activation loop and a site carboxyterminal to the catalytic domain, situated in a hydrophobic motif site FXXFS ...
Bjørn Altermark (3399716), Concetta De Santi (3151257), Donatella de Pascale (829054), Luca Ambrosino (3399614), Marcin Pierechod (3399617), Nils-Peder Willassen (162352)   +5 more
core   +5 more sources

Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates [PDF]

Cell Death & Disease, 2018
AbstractAutophagy plays a central role in degrading misfolded proteins such as mutated superoxide dismutase 1 (SOD1), which forms aggregates in motor neurons and is involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). Autophagy is activated when UNC-51-like kinase 1 (ULK1) is phosphorylated at S555 and activated by AMP-activated protein
Jing Sun, Yarong Mu, Yuanyuan Jiang, Ruilong Song, Jianxin Yi, Jingsong Zhou, Jun Sun, Xinan Jiao, Richard A. Prinz, Yi Li, Xiulong Xu   +10 more
openaire   +2 more sources

Melanoma: Pathogenesis and Targeted Therapy

MedComm, Volume 7, Issue 1, January 2026.
The treatment landscape for advanced melanoma has evolved significantly. BRAF–MEK inhibitor combinations are standard for BRAF‐mutant melanoma, whereas targeting NRAS mutations is more challenging, with MEK inhibitors like tunlametinib emerging as an option.
Yang Fu, Jie Liu, Zeming Mo, Bin Wang, Yaotiao Deng, Yu Jiang   +5 more
wiley   +1 more source

mTORC1 Targets the Translational Repressor 4E-BP2, but Not S6 Kinase 1/2, to Regulate Neural Stem Cell Self-Renewal In Vivo

Cell Reports, 2013
The mammalian target of rapamycin complex 1 (mTORC1) integrates signals important for cell growth, and its dysregulation in neural stem cells (NSCs) is implicated in several neurological disorders associated with abnormal neurogenesis and brain size ...
Nathaniel W. Hartman, Tiffany V. Lin, Longbo Zhang, Grace E. Paquelet, David M. Feliciano, Angélique Bordey   +5 more
doaj   +1 more source

Amino acids regulate energy utilization through mammalian target of rapamycin complex 1 and adenosine monophosphate activated protein kinase pathway in porcine enterocytes

Animal Nutrition, 2020
As major fuels for the small intestinal mucosa, dietary amino acids (AA) are catabolized in the mitochondria and serve as sources of energy production.
Hao Xiao, Cuifang Zha, Fangyuan Shao, Li Wang, Bi'e Tan   +4 more
doaj   +1 more source

Roles of mechanistic target of rapamycin and transforming growth factor-B signaling in the molting gland (Y-organ) of the blackback land crab, Gecarcinus lateralis [PDF]

, 2016
Molting in decapod crustaceans is controlled by molt-inhibiting hormone (MIH), an eyestalk neuropeptide that suppresses production of ecdysteroids by a pair of molting glands (Y-organs or YOs). Eyestalk ablation (ESA) activates the YOs, which hypertrophy
Abuhagr, Ali M., Chang, Ernest S., Chang, Sharon A., MacLea, Kyle S., Mudron, Megan R., Mykles, Donald L.   +5 more
core   +2 more sources

The α‐isoform of glycogen synthase kinase‐3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase‐activated protein kinase‐1 in vitro

FEBS Letters, 1994
The α‐isoform of glycogen synthase kinase‐3 (GSK3α) was inactivated by 80% towards a synthetic peptide substrate upon incubation with Mg‐ATP and either MAP kinase‐activated protein (MAPKAP) kinase‐1 or p70 S6 kinase. Inactivation by either kinase resulted from the phosphorylation of Ser‐21 and was reversed by treatment with protein phosphatase 2A1 ...
Sutherland, Calum, Cohen, Philip
openaire   +3 more sources

PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotection.

PLoS ONE, 2012
Emerging strategies that center upon the mammalian target of rapamycin (mTOR) signaling for neurodegenerative disorders may bring effective treatment for a number of difficult disease entities.
Zhao Zhong Chong, Yan Chen Shang, Shaohui Wang, Kenneth Maiese   +3 more
doaj   +1 more source

Effect of IRS4 levels on PI 3-kinase signalling. [PDF]

PLoS ONE, 2013
Insulin receptor substrate 1 (IRS1) and IRS2 are well-characterized adapter proteins that relay signals from receptor tyrosine kinases to downstream components of signalling pathways. In contrast, the function of IRS4 is not well understood.
Gerta Hoxhaj, Kumara Dissanayake, Carol MacKintosh   +2 more
doaj   +1 more source

TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis. [PDF]

, 2014
In addition to regulating the activation of nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK), TGF-β activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy.
Seki, Ekihiro
core   +2 more sources