Journal of Pharmacological Sciences, 2006 .: Hyperproliferation of phenotypically modified vascular smooth muscle cells (VSMCs) is one of the major factors in the development of atherosclerosis and restenosis.
Emi Arakawa, Kazuhide Hasegawa
doaj
PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotection.
PLoS ONE, 2012 Emerging strategies that center upon the mammalian target of rapamycin (mTOR) signaling for neurodegenerative disorders may bring effective treatment for a number of difficult disease entities.
Zhao Zhong Chong +3 more
doaj +1 more source
Celecoxib inhibits proliferation and survival of chronic myelogeous leukemia (CML) cells via AMPK-dependent regulation of β-catenin and mTORC1/2. [PDF]
, 2016 CML is effectively treated with tyrosine kinase inhibitors (TKIs). However, the efficacy of these drugs is confined to the chronic phase of the disease and development of resistance to TKIs remains a pressing issue.
Calabretta, Bruno +10 more
core +2 more sources
Genetic mutations disrupt the coordinated mode of tyrosinase's intra‐melanosomal domain
Protein Science, Volume 34, Issue 8, August 2025.Abstract Oculocutaneous albinism type 1 is a genetic disorder caused by the disruption of tyrosinase activity in the melanogenesis pathway. The tyrosinase's intramelanosomal domain can be subdivided into the catalytic and Cys‐rich subdomains, integral for protein stability and catalytic activity.
Sarah Toay, Yuri V. Sergeev
wiley +1 more source
Physiological Reports, 2022 Lactate is a metabolic product of glycolysis and has recently been shown to act as a signaling molecule that induces adaptations in oxidative metabolism.
Takanaga Shirai +5 more
doaj +1 more source
Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells - Activation of protein kinase B by wortmannin-sensitive and -insensittve mechanisms [PDF]
, 1997 Previous studies using L6 myotubes have suggested that glycogen synthase kinase-3 (GSK-3) is phosphoryl ated and inactivated in response to insulin by protein kinase B (PKB, also known as Akt or RAG) (Cross, D, A, E., Alessi, D, R., Cohen, P ...
Denton, Richard M. +5 more
core
S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance. [PDF]
, 2016 Hyperactivation of the mTOR pathway impairs hematopoietic stem cell (HSC) functions and promotes leukemogenesis. mTORC1 and mTORC2 differentially control normal and leukemic stem cell functions.
Carlesso, Nadia +10 more
core +1 more source
Mitochondrial DNA affects tau phosphorylation in aging and Alzheimer's disease
Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.Abstract INTRODUCTION Impaired mitochondrial function is seen in Alzheimer's disease (AD), but its role is unclear. Mitochondrial DNA (mtDNA) supports bioenergetic metabolism, but it is uncertain how it might influence AD neuropathology. METHODS We used cytoplasmic hybrid (cybrid) cell lines made from SH‐SY5Y cells expressing mtDNA from cognitively ...
Riley E. Kemna +11 more
wiley +1 more source
Effect of IRS4 levels on PI 3-kinase signalling. [PDF]
PLoS ONE, 2013 Insulin receptor substrate 1 (IRS1) and IRS2 are well-characterized adapter proteins that relay signals from receptor tyrosine kinases to downstream components of signalling pathways. In contrast, the function of IRS4 is not well understood.
Gerta Hoxhaj +2 more
doaj +1 more source
Immunolocalization of phospho-S6 kinases: a new way to detect mitosis in tissue sections and in cell culture [PDF]
, 2018 During a study on the mTor pathway in the rat kidney we observed a striking increase of the phosphorylation of the S6 kinase in mitosis. In cryostat sections of perfusion-fixed tissue mitotic cells appeared as bright spots in immunofluorescence using an ...
Kaissling, Brigitte +6 more
core