Results 101 to 110 of about 20,664 (187)
p21-activated Kinase 1 Is Activated through the Mammalian Target of Rapamycin/p70 S6 Kinase Pathway and Regulates the Replication of Hepatitis C Virus in Human Hepatoma Cells [PDF]
Journal of Biological Chemistry, 2007 Cellular mechanisms that regulate the replication of hepatitis C virus (HCV) RNA are poorly understood. p21-activated kinase 1 (PAK1) is a serine/threonine kinase that has been suggested to participate in antiviral signaling. We studied its role in the cellular control of HCV replication.
Hisashi, Ishida +3 more
openaire +2 more sources
Bioinorganic Chemistry and Applications, Volume 2026, Issue 1, 2026.Objective Radioactive iodine therapy is a mainstay for recurrent and metastatic differentiated thyroid cancer. However, a substantial portion of differentiated thyroid cancer patients exhibits dedifferentiation status with a lack of sodium iodide symporter functionality and expression, as well as downregulated thyroid‐specific proteins and ...
Ji Min Oh +5 more
wiley +1 more source
Alterations of Akt1 (PKBα) and p70S6K in Transient Focal Ischemia
Neurobiology of Disease, 2001 The serine-threonine kinase Akt1 promotes cell survival through inhibition of apoptosis. One of the potential downstream targets of Akt1 is p70 S6 kinase, p70S6K, an enzyme implicated in the regulation of protein synthesis. In this study, we investigated
Shorena Janelidze +3 more
doaj +1 more source
Metformin: A Prospective Alternative for the Treatment of Chronic Pain
Frontiers in Pharmacology, 2020 Metformin (biguanide) is a drug widely used for the treatment of type 2 diabetes. This drug has been used for 60 years as a highly effective antihyperglycemic agent.
Guadalupe Del Carmen Baeza-Flores +6 more
doaj +1 more source
Physiological Reports, 2022 Lactate is a metabolic product of glycolysis and has recently been shown to act as a signaling molecule that induces adaptations in oxidative metabolism.
Takanaga Shirai +5 more
doaj +1 more source
Immunolocalization of phospho-S6 kinases: a new way to detect mitosis in tissue sections and in cell culture [PDF]
, 2018 During a study on the mTor pathway in the rat kidney we observed a striking increase of the phosphorylation of the S6 kinase in mitosis. In cryostat sections of perfusion-fixed tissue mitotic cells appeared as bright spots in immunofluorescence using an ...
Kaissling, Brigitte +6 more
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Stimulation of protein kinase B and p70 S6 kinase by the histamine H1 receptor in DDT1MF‐2 smooth muscle cells [PDF]
British Journal of Pharmacology, 2002 Previous studies have shown that the histamine H1 receptor activates p42/p44 mitogen‐activated protein kinases (MAPK) in DDT1MF‐2 smooth muscle cells via a phosphatidylinositol 3‐kinase (PI‐3K)‐dependent pathway. In this study the effect of histamine H1 receptor stimulation on protein kinase B (PKB) and p70 S6 kinase, both of which are downstream ...
openaire +2 more sources
, 2023 Supplementary Figure 1 from p70 S6 Kinase Promotes Epithelial to Mesenchymal Transition through Snail Induction in Ovarian Cancer ...
Alice S.T. Wong +4 more
openaire +1 more source
Exploration, Volume 5, Issue 6, December 2025.We developed a spatiotemporal targeting oncolytic bacterial therapy system, the STEPT (spatiotemporal targeting EcN‐pfo terminator) system, which injects azide hyaluronic acid hydrogel into tumors to capture DBCO‐labeled engineered Escherichia coli Nissle 1917 (EcN).
Yu‐Jia Wang +9 more
wiley +1 more source
Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells - Activation of protein kinase B by wortmannin-sensitive and -insensittve mechanisms [PDF]
, 1997 Previous studies using L6 myotubes have suggested that glycogen synthase kinase-3 (GSK-3) is phosphoryl ated and inactivated in response to insulin by protein kinase B (PKB, also known as Akt or RAG) (Cross, D, A, E., Alessi, D, R., Cohen, P ...
Denton, Richard M. +5 more
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