Results 111 to 120 of about 20,664 (187)

Celecoxib inhibits proliferation and survival of chronic myelogeous leukemia (CML) cells via AMPK-dependent regulation of β-catenin and mTORC1/2. [PDF]

, 2016
CML is effectively treated with tyrosine kinase inhibitors (TKIs). However, the efficacy of these drugs is confined to the chronic phase of the disease and development of resistance to TKIs remains a pressing issue.
Calabretta, Bruno, Canonico, Pier Luigi, Condorelli, Fabrizio, De Dominici, Marco, Genazzani, Armando A, Gnemmi, Ilaria, Mariani, Samanta A., Minassi, Alberto, Minieri, Valentina, Riva, Beatrice, Salomoni, Paolo   +10 more
core   +2 more sources

Curcumin's Therapeutic Potential in Ovarian Cancer: Current Insights and Future Perspectives

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This review provides an overview of ovarian cancer, examines curcumin's emerging role in its treatment, identifies existing research gaps, and outlines a roadmap for future studies aimed at fully exploring curcumin's therapeutic potential in the management of ovarian cancer.
Smirnova Elena, Sureshbabu Anjana, Do Thi Cat Tuong, Sungyeon Chin, Mohammad Moniruzzaman, Bui Huy Doanh, Adhimoolam Karthikeyan, Taesun Min   +7 more
wiley   +1 more source

High dietary lipid level is associated with persistent hyperglycaemia and downregulation of muscle Akt-mTOR pathway in Senegalese sole (Solea senegalensis). [PDF]

PLoS ONE, 2014
High levels of dietary lipids are incorporated in feeds for most teleost fish to promote growth and reduce nitrogen waste. However, in Senegalese sole (Solea senegalensis) previous studies revealed that increasing the level of dietary lipids above 8 ...
Pedro Borges, Luísa M P Valente, Vincent Véron, Karine Dias, Stéphane Panserat, Françoise Médale   +5 more
doaj   +1 more source

Myostatin dysfunction is associated with reduction in overload induced hypertrophy of soleus muscle in mice [PDF]

, 2017
Acknowledgements This project was also supported by Marie Curie International Reintegration Grant 249156 (A. Lionikas) and the grants VP1-3.1-SMM-01-V-02-003 (A. Kilikevicius) and MIP-067/2012 (T. Venckunas) from the Research Council of Lithuania as well
Alhindi, Y., Baltusnikas, J., Bunger, L., Kilikevicius, A., Lionikas, A., Minderis, P., Ratkevicius, A., Venckunas, T.   +7 more
core   +1 more source

Supplementary Table 1 from p70 S6 Kinase Promotes Epithelial to Mesenchymal Transition through Snail Induction in Ovarian Cancer Cells

, 2023
Supplementary Table 1 from p70 S6 Kinase Promotes Epithelial to Mesenchymal Transition through Snail Induction in Ovarian Cancer ...
Alice S.T. Wong, Hextan Y.S. Ngan, Annie N.Y. Cheung, Hong Y. Zhou, Yuen L. Pon   +4 more
openaire   +1 more source

Mechano-transduction to muscle protein synthesis is modulated by FAK [PDF]

, 2018
We examined the involvement of focal adhesion kinase (FAK) in mechano-regulated signalling to protein synthesis by combining muscle-targeted transgenesis with a physiological model for un- and reloading of hindlimbs.
Durieux, Anne-Cecile, Flueck, Martin, Freyssenet, Damien, Klossner, Stephan   +3 more
core  

Collagen Signaling via DDR1 Exacerbates Barriers to Macromolecular Drug Delivery in a 3D Model of Pancreatic Cancer Fibrosis

Small, Volume 21, Issue 50, December 17, 2025.
This work investigates the role of collagen I signaling in the fibrotic barrier to macromolecular drug delivery in pancreatic cancer. Mechanistic analyses revealed the involvement of the receptor tyrosine kinase DDR1 signaling through PI3K/AKT/mTOR.
Mayu Ohira, Moe Kitamura, Hiroyo Iwasaki, Haruko Ohta‐Okano, Hiyori Tsujii, Reika Nakamura, Takuya Nakazawa, Akihiro Nishiguchi, Masaya Yamamoto, Kensuke Osada, Shinichi Toyooka, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano, Hiroyoshi Y. Tanaka   +14 more
wiley   +1 more source

Rapamycin induces transactivation of the EGFR and increases cell survival. [PDF]

, 2009
The mammalian target of rapamycin (mTOR) signaling network regulates cell growth, proliferation and cell survival. Deregulated activation of this pathway is a common event in diverse human diseases such as cancers, cardiac hypertrophy, vascular ...
Chaturvedi, D, Cohen, MS, Gao, X, Patel, TB, Taunton, J   +4 more
core   +2 more sources

Muscle regeneration is improved by hot water immersion but unchanged by cold following a simulated musculoskeletal injury in humans

The Journal of Physiology, Volume 603, Issue 23, Page 7603-7625, December 1, 2025.
Abstract figure legend Thirty‐four participants underwent muscle damage (electrically stimulated eccentric contractions) triggering regenerative processes following myofiber necrosis. Participants were treated for 10 days cold (CWI) (15 min, 12{degree sign}C), thermoneutral (TWI) (30 min, 32{degree sign}C) or hot (HWI) (60 min, 42{degree sign}C) water ...
Valentin Dablainville, Adèle Mornas, Tom Normand‐Gravier, Maha Al‐Mulla, Emmanouil Papakostas, Bruno Olory, Theodorakys Marin Fermin, Frantzeska Zampeli, Nelda Nader, Marine Alhammoud, Freya Bayne, Anthony M. J. Sanchez, Marco Cardinale, Robin Candau, Henri Bernardi, Sébastien Racinais   +15 more
wiley   +1 more source

CCL2 is a Potent Regulator of Prostate Cancer Cell Migration and Proliferation

Neoplasia: An International Journal for Oncology Research, 2006
Tumor cells in the bone interact with the microenvironment to promote tumor cell survival and proliferation, resulting in a lethal phenotype for patients with advanced prostate cancer.
Robert D. Loberg, LaShon L. Day, Jason Harwood, Chi Ying, Lauren N. St. John, Ryan Giles, Chris K. Neeley, Kenneth J. Pienta   +7 more
doaj   +1 more source