Results 121 to 130 of about 24,655 (236)

Role of mTOR signaling in tumor microenvironment. An overview [PDF]

, 2018
The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME).
Bazzichetto, Chiara, Bria, Emilio, Ciuffreda, L., Cognetti, F., COGNETTI, FRANCESCO, Conciatori, Fabiana, Falcone, I., Milella, M., Pilotto, Sara   +8 more
core   +2 more sources

Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease

Advanced Science, Volume 12, Issue 22, June 12, 2025.
This study has unveiled significant new insights into the role of MS4A4A in Alzheimer's disease‐related epilepsy, highlighting its impact on microglial phagocytosis, mitochondrial metabolism, and cytoskeleton, and demonstrating its therapeutic potential in epilepsy management.
Meng Jiang, Qingqing Li, Jianhui Chen, Ruochong Li, Jun Yao, Yong Hu, Haizheng Zhang, Lixin Cai, Maoguo Luo, Yu Sun, Wenwen Zeng   +10 more
wiley   +1 more source

Circumventing Cellular Control of PP2A by Methylation Promotes Transformation in an Akt-Dependent Manner

Neoplasia: An International Journal for Oncology Research, 2012
Heterotrimeric protein phosphatase 2A (PP2A) consists of catalytic C (PP2Ac), structural A, and regulatory B-type subunits, and its dysfunction has been linked to cancer.
Jennifer B. Jackson, David C. Pallas
doaj   +1 more source

Impaired overload-induced muscle growth is associated with diminished translational signalling in aged rat fast-twitch skeletal muscle [PDF]

, 2006
Impaired overload-induced protein synthesis and growth in aged fast-twitch skeletal muscle may result from diminished responsiveness of signalling intermediates controlling protein translation.
Alway, Armstrong, Baar, Baillie, Bastien, Blough, Bodine, Bolster, Bolster, Bolster, Browne, Browne, Browne, Burnett, Chan, Cheng, Childs, Cuthbertson, Dardevet, Degens, Gingras, Gordon, Gordon, Guillet, Hay, Hernandez, Horman, Häkkinen, Häkkinen, Ianuzzo, Isotani, Jefferies, Kimball, Kimball, Krause, Li, Marcinek, Martin-Perez, Moller, Morris, Nader, Nader, Nave, Parkington, Parkington, Pearson, Pehme, Pehme, Pende, Pullen, Reynolds, Rose, Sekulic, Shah, Stolovich, Tamaki, Terada, Thomson, Wang, Wang, Welle, Welle, Welle, Welle, Weng, Wong, Wong, Yarasheski   +67 more
core   +2 more sources

Expert Consensus on the Clinical Application of PI3K/AKT/mTOR Inhibitors in the Treatment of Breast Cancer (2025 Edition)

Cancer Innovation, Volume 4, Issue 3, June 2025.
ABSTRACT Background The phosphoinositide 3‐kinase (PI3K)/protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) signaling pathway (PAM pathway) plays a critical role in breast cancer pathogenesis and progression, and is closely linked with resistance to endocrine therapy in advanced breast cancer.
The Breast Cancer Expert Committee of the National Quality Control Center for Cancer, The Expert Committee on Cancer Prevention and Treatment of the Health China Research Center, The Society of Clinical Research on Oncology Medications of the China Anti‐Cancer Association, The Society of Onco‐Pathology of the China Anti‐Cancer Association   +3 more
wiley   +1 more source

DDR2‐mediated autophagy inhibition contributes to angiotensin II‐induced adventitial remodeling

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
Ddr2 promotes PI3K/Akt/mTOR mediated autophagy inhibition, which contributes to Ang II‐induced AF phenotypic switch. Abstract Aims Adventitial remodelling in hypertension is characterized by a transformation of adventitial fibroblasts (AFs) into myofibroblasts.
Gaojian Huang, Zhilei Cong, Yuhao Zhao, Tong Zhu, Ruosen Yuan, Zhen Li, Xuelian Wang, Jia Qi   +7 more
wiley   +1 more source

Phosphatidylinositol 3-Kinase (PI-3K)/Akt but Not PI-3K/p70 S6 Kinase Signaling Mediates IGF-1-Promoted Lens Epithelial Cell Survival

Investigative Opthalmology & Visual Science, 2004
To investigate the ability of insulin-like growth factor (IGF)-1 to prevent apoptosis in lens epithelial cells and the involvement of phosphatidylinositol 3-kinase (PI-3K)/Akt and PI-3K/p70 S6 kinase (p70 S6K) signaling in the cell-survival process.Apoptosis in rabbit lens epithelial cell cultures was induced by staurosporine (10 ng/mL).
Gudiseva Chandrasekher, D. Sailaja
openaire   +3 more sources

CCL2 is a Potent Regulator of Prostate Cancer Cell Migration and Proliferation

Neoplasia: An International Journal for Oncology Research, 2006
Tumor cells in the bone interact with the microenvironment to promote tumor cell survival and proliferation, resulting in a lethal phenotype for patients with advanced prostate cancer.
Robert D. Loberg, LaShon L. Day, Jason Harwood, Chi Ying, Lauren N. St. John, Ryan Giles, Chris K. Neeley, Kenneth J. Pienta   +7 more
doaj   +1 more source

Neuronal human BACE1 knock-in induces systemic diabetes in mice [PDF]

, 2016
Acknowledgements The authors thank S. Tammireddy (Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness, UK) for technical support with the lipidomics component. Funding We would like to thank R.
Dekeryte, Ruta, Delibegovic, Mirela, Doherty, Mary K., Koss, David, Mingarelli, Marco, Mody, Nimesh, Platt, Bettina, Pluci??ska, Kaja, Riedel, Gernot, Shearer, Kirsty, Welch, Andy, Whitfield, Phillip, Whitfield, Phillip D.   +12 more
core   +3 more sources

Cisplatin‐Induced Muscle Wasting and Atrophy: Molecular Mechanism and Potential Therapeutic Interventions

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Platinum‐based chemotherapeutics, particularly cisplatin, are crucial in the treatment of various malignancies due to their strong antitumor effects. However, a significant side effect of cisplatin is muscle atrophy, which severely impairs physical strength, diminishes quality of life and complicates cancer therapy.
Ko‐Chieh Huang, Yi‐Fen Chiang, Mohamed Ali, Shih‐Min Hsia   +3 more
wiley   +1 more source