Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase [PDF]
, 2001 Background: The p70 S6 kinase, like several other AGC family kinases, requires for activation the concurrent phosphorylation of a site on its activation loop and a site carboxyterminal to the catalytic domain, situated in a hydrophobic motif site FXXFS ...
Bjørn Altermark (3399716) +5 more
core +5 more sources
p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/β1 integrin signaling activation [PDF]
, 2014 Peritoneal dissemination as a manifestation of ovarian cancer is an adverse prognostic factor associated with poor clinical outcome, and is thus a potentially promising target for improved treatment. Sphere forming cells (multicellular spheroids) present
Chan, DTM +4 more
core
Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice. [PDF]
, 2019 We examined the impact of statins on Yes-associated Protein (YAP) localization, phosphorylation and transcriptional activity in human and mouse pancreatic ductal adenocarcinoma (PDAC) cells.
Chang, Hui-Hua +7 more
core +2 more sources
Controlled trial of lovastatin combined with an open-label treatment of a parent-implemented language intervention in youth with fragile X syndrome. [PDF]
, 2020 BackgroundThe purpose of this study was to conduct a 20-week controlled trial of lovastatin (10 to 40 mg/day) in youth with fragile X syndrome (FXS) ages 10 to 17 years, combined with an open-label treatment of a parent-implemented language intervention (
Abbeduto, Leonard +10 more
core
Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress [PDF]
, 2010 The large serine/threonine protein kinase mTOR regulates cellular and organismal homeostasis by coordinating anabolic and catabolic processes with nutrient, energy, and oxygen availability and growth factor signaling.
Peterson, Timothy Richard +2 more
core +1 more source
Activation of p70 Ribosomal Protein S6 Kinase Is an Essential Step in the DNA Damage-dependent Signaling Pathway Responsible for the Ultraviolet B-mediated Increase in Interstitial Collagenase (MMP-1) and Stromelysin-1 (MMP-3) Protein Levels in Human Dermal Fibroblasts [PDF]
, 2000 Peter Brenneisen +4 more
openalex +1 more source
Journal of Biological Chemistry, 2014 Background: The mTOR complex 1 (mTORC1) phosphorylates ribosomal S6 kinase (S6K1) on Thr-389, leading to S6K1 activation. Results: Inhibition of SIRT1/2, members of the sirtuin family of proteins, induces S6K1 acetylation and inhibits mTORC1-dependent ...
Sungki Hong +4 more
semanticscholar +1 more source
Animal Nutrition, 2020 As major fuels for the small intestinal mucosa, dietary amino acids (AA) are catabolized in the mitochondria and serve as sources of energy production.
Hao Xiao +4 more
doaj
Molecular MedicineBackground Recent studies have identified hearing loss (HL) as a primary risk factor for Alzheimer’s disease (AD) onset. However, the mechanisms linking HL to AD are not fully understood. This study explored the effects of drug-induced hearing loss (DIHL)
Yoo-Seung Ko +11 more
doaj +1 more source
Alterations of Akt1 (PKBα) and p70S6K in Transient Focal Ischemia
Neurobiology of Disease, 2001 The serine-threonine kinase Akt1 promotes cell survival through inhibition of apoptosis. One of the potential downstream targets of Akt1 is p70 S6 kinase, p70S6K, an enzyme implicated in the regulation of protein synthesis. In this study, we investigated
Shorena Janelidze +3 more
doaj