Results 181 to 187 of about 20,664 (187)

Interferon regulatory factor 1 eliminates mycobacteria by suppressing p70 S6 kinase via mechanistic target of rapamycin signaling

Journal of Infection, 2019
Although it has been reported that Interferon regulatory factor 1 (IRF1) inhibits Mycobacterium tuberculosis (Mtb) infection via inducible nitric oxide synthase (iNOS) in mice, how it counteracts with mycobacterial infection in human remains largely obscure.
Zhou, XY, Yang, JH, Zhang, ZL, Zhang, LJ, Lie, LM, Zhu, B, Xu, L (Lei), Gao, YC, Du, XL, Huang, YQ, Wang, RN, Liu, HL, Li, YF, Hu, SF, Zhou, CY, Wen, Q, Pan, Qiuwei, Ma, L   +17 more
openaire   +2 more sources

Serum Lipid and Protein Changes in Healthy Dyslipidemic Subjects Given a Selective Inhibitor of p70 S6 Kinase‐1

The Journal of Clinical Pharmacology, 2017
AbstractThe safety, pharmacokinetic, and pharmacodynamic effects of LY2584702, a selective inhibitor for p70 S6 serine/threonine protein kinase‐1, were evaluated in healthy dyslipidemic volunteers. LY2584702 was tolerated well as a monotherapy and dose‐dependently reduced low‐density lipoprotein cholesterol and triglycerides by up to 60% and 50 ...
Jennifer K, Leohr, Debra, Luffer-Atlas, M Jane, Luo, David J, DeBrota, Colin, Green, Thomas E, Mabry, Jeffrey G, Suico   +6 more
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Negative regulation of melanogenesis by phospholipase D1 through mTOR/p70 S6 kinase 1 signaling in mouse B16 melanoma cells

Journal of Cellular Physiology, 2005
AbstractMelanogenesis is a principal parameter of differentiation in melanocytes and melanoma cells. Our recent study has demonstrated that phospholipase D1 (PLD1) regulates the melanogenic signaling through modulating the expression of tyrosinase, the rate‐limiting step enzyme in the melanin biosynthesis.
Kenji, Ohguchi, Yoshiko, Banno, Yoshihito, Nakagawa, Yukihiro, Akao, Yoshinori, Nozawa   +4 more
openaire   +2 more sources

N-terminal variant Asp14Asn of the human p70 S6 Kinase 1 enhances translational signaling causing different effects in developing and mature neuronal cells

Neurobiology of Learning and Memory, 2020
The ribosomal p70 S6 Kinase 1 (S6K1) has been implicated in the etiology of complex neurological diseases including autism, depression and dementia. Though no major gene disruption has been reported in humans in RPS6KB1, single nucleotide variants (SNVs) causing missense mutations have been identified, which have not been assessed for their impact on ...
Janani Priya Venkatasubramani, Prakash Subramanyam, Rakhi Pal, Bharath K. Reddy, Durga Jeyalakshmi Srinivasan, Sumantra Chattarji, Ivan Iossifov, Eric Klann, Aditi Bhattacharya   +8 more
openaire   +2 more sources

Involvement of adenylate cyclase and p70 S6 -kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1

Pfl�gers Archiv European Journal of Physiology, 1999
Our previous results show that recombinant gp41 (aa565-647), the extracellular domain of HIV-1 transmembrane glycoprotein, stimulates interleukin-10 (IL-10) production in human monocytes. The signal cascade transducing this effect is not yet clear.
M, Barcova, C, Speth, L, Kacani, F, Uberall, H, Stoiber, M P, Dierich   +5 more
openaire   +2 more sources

Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates PD-L1 levels in human cancer cells through enhancing protein stabilization accompanied with enhanced β-TrCP degradation

Oncogene, 2019
The involvement of mammalian target of rapamycin (mTOR) in the positive regulation of oncogenesis has been well documented and thus mTOR has emerged as an attractive cancer therapeutic target. Although rapamycin and its analogues (rapalogs) are FDA-approved for the treatment of certain cancers, major success in targeting mTOR, particularly with new ...
Liang, Deng, Guoqing, Qian, Shuo, Zhang, Hongmei, Zheng, Sonqing, Fan, Gregory B, Lesinski, Taofeek K, Owonikoko, Suresh S, Ramalingam, Shi-Yong, Sun   +8 more
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Angiotensin II stimulates phosphorylation of 4E-binding protein 1 and p70 S6 kinase in cultured vascular smooth muscle cells.

Acta pharmacologica Sinica, 2004
To examine the regulatory effects of angiotensin II (Ang II) on the phosphorylation of 4E-binding protein 1 (4E-BP1) and p70 S6 kinase in cultured vascular smooth muscle cells (VSMC), and the contribution of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathway in this process.VSMC obtained from rat thoracic aortas were cultured.
Na, Li, Ke-gui, Wu, Xiang-yu, Wang, Liang-di, Xie, Chang-sheng, Xu, Hua-jun, Wang   +5 more
openaire   +1 more source