TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activity. [PDF]
PLoS ONE, 2012 Insulin/IGF-1 signaling plays a pivotal role in the regulation of cellular homeostasis through its control of glucose metabolism as well as due to its effects on cell proliferation.
Marisa J Wainszelbaum +6 more
doaj +5 more sources
Targeting 3-phosphoinoside-dependent kinase-1 to inhibit insulin-like growth factor-I induced AKT and p70 S6 kinase activation in breast cancer cells. [PDF]
PLoS ONE, 2012 Binding of IGF to IGF-IR activates PI3K to generate PIP3 which in turn recruits and activates proteins that contain a pleckstrin homology (PH) domain, including AKT and PDK1.
Sangita M Baxi +4 more
doaj +4 more sources
Interactions between sleep disruption, motor learning, and p70 S6 kinase 1 signaling. [PDF]
Sleep, 2020 Abstract Offline gains in motor performance after initial motor learning likely depend on sleep, but the molecular mechanisms by which this occurs are understudied. Regulation of mRNA translation via p70 S6 kinase 1 (S6K1) signaling represents one potential mechanism, as protein synthesis is thought to be increased during sleep compared ...
Kam K +10 more
europepmc +4 more sources
TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1. [PDF]
Sci Rep, 2013 There is growing interest in identifying regulators of autophagy. The molecular mechanism underlying transforming growth factor-β activated kinase 1 (TAK1)-induced autophagy is poorly understood. We found that TAK1 inhibits p70 S6 kinase1 (S6K1) phosphorylation by interfering interaction of raptor with S6K1, thus inducing autophagy.
Shin JH +6 more
europepmc +5 more sources
Targeting Translation Control with p70 S6 Kinase 1 Inhibitors to Reverse Phenotypes in Fragile X Syndrome Mice. [PDF]
Neuropsychopharmacology, 2016 Aberrant neuronal translation is implicated in the etiology of numerous brain disorders. Although mTORC1-p70 ribosomal S6 kinase 1 (S6K1) signaling is critical for translational control, pharmacological manipulation in vivo has targeted exclusively mTORC1 due to the paucity of specific inhibitors to S6K1.
Bhattacharya A +7 more
europepmc +4 more sources
Resveratrol attenuates doxorubicin-induced cardiomyocyte death via inhibition of p70 S6 kinase 1-mediated autophagy. [PDF]
J Pharmacol Exp Ther, 2012 Resveratrol is a plant-derived polyphenol that can attenuate the cardiotoxic effects of doxorubicin (DOX), a powerful antibiotic widely used in cancer chemotherapy. However, the underlying protective mechanisms of resveratrol remain elusive. Here, we show that resveratrol inhibited DOX-induced autophagy and cardiomyocyte death, and autophagy ...
Xu X +4 more
europepmc +4 more sources
Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis. [PDF]
Cell Metab, 2008 p70 S6 kinase 1 (S6K) is a major downstream effector of the mammalian target of rapamycin (mTOR), primarily implicated in the control of protein synthesis, cell growth, and proliferation. Here we demonstrate that specific bidirectional molecular targeting of mediobasal hypothalamic (MBH) S6K activity in rats is sufficient to significantly alter food ...
Blouet C, Ono H, Schwartz GJ.
europepmc +4 more sources
Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice. [PDF]
Neuron, 2012 Fragile X syndrome (FXS) is the leading inherited cause of autism and intellectual disability. Aberrant synaptic translation has been implicated in the etiology of FXS, but most lines of research on therapeutic strategies have targeted protein synthesis indirectly, far upstream of the translation machinery.
Bhattacharya A +5 more
europepmc +4 more sources
Endothelial p70 S6 Kinase 1 in Regulating Tumor Angiogenesis [PDF]
Cancer Research, 2008 Abstract The p70 S6 kinase 1 (p70S6K1) exerts its function in regulating protein synthesis, cell proliferation, cell cycle progression, and cell survival in response to growth factors and other cellular signals. But the direct effect of p70S6K1 in regulating tumor growth and angiogenesis remains to be elucidated.
Ling-Zhi, Liu +3 more
openaire +2 more sources