Results 201 to 210 of about 24,655 (236)

SOX10 mediates glioblastoma cell-state plasticity. [PDF]

EMBO Rep
Man KH, Wu Y, Gao Z, Spreng AS, Keding J, Mangei J, Boskovic P, Mallm JP, Liu HK, Imbusch CD, Lichter P, Radlwimmer B.   +11 more
europepmc   +1 more source

Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase. [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2002
Cardiomyocytes in culture can survive low or mild doses of oxidants but later increase cell volume and protein content. To understand the mechanism, we determined the early signaling events of oxidative stress.
Victoria C. Tu, J. J. Bahl, Qin M. Chen
semanticscholar   +3 more sources

Rictor is a novel target of p70 S6 kinase-1 [PDF]

Oncogene, 2010
The rapamycin-insensitive companion of mammalian target of rapamycin (mTOR) (Rictor) is a key member of mTOR complex-2 (mTORC2), which phosphorylates the AGC kinases Akt/PKB, PKC and SGK1 at a C-terminal hydrophobic motif. We identified several novel sites on Rictor that are phosphorylated, including Thr1135, which is conserved across all vertebrates ...
Caroline Treins, Caroline Treins, P. H. Warne, Mark A. Magnuson, Mario Pende, Julian Downward   +5 more
semanticscholar   +4 more sources

Some of the next articles are maybe not open access.

Related searches:

Serum Lipid and Protein Changes in Healthy Dyslipidemic Subjects Given a Selective Inhibitor of p70 S6 Kinase‐1

The Journal of Clinical Pharmacology, 2018
AbstractThe safety, pharmacokinetic, and pharmacodynamic effects of LY2584702, a selective inhibitor for p70 S6 serine/threonine protein kinase‐1, were evaluated in healthy dyslipidemic volunteers. LY2584702 was tolerated well as a monotherapy and dose‐dependently reduced low‐density lipoprotein cholesterol and triglycerides by up to 60% and 50 ...
J. Leohr, D. Luffer-Atlas, M. Luo, D. DeBrota, Colin J. Green, T. Mabry, J. Suico   +6 more
semanticscholar   +4 more sources

N-terminal variant Asp14Asn of the human p70 S6 Kinase 1 enhances translational signaling causing different effects in developing and mature neuronal cells

Neurobiology of Learning and Memory, 2020
The ribosomal p70 S6 Kinase 1 (S6K1) has been implicated in the etiology of complex neurological diseases including autism, depression and dementia. Though no major gene disruption has been reported in humans in RPS6KB1, single nucleotide variants (SNVs) causing missense mutations have been identified, which have not been assessed for their impact on ...
Janani Priya Venkatasubramani, Prakash Subramanyam, Rakhi Pal, B. Reddy, D. J. Srinivasan, S. Chattarji, I. Iossifov, E. Klann, A. Bhattacharya   +8 more
semanticscholar   +4 more sources

The α‐isoform of glycogen synthase kinase‐3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase‐activated protein kinase‐1 in vitro

FEBS Letters, 1994
The α‐isoform of glycogen synthase kinase‐3 (GSK3α) was inactivated by 80% towards a synthetic peptide substrate upon incubation with Mg‐ATP and either MAP kinase‐activated protein (MAPKAP) kinase‐1 or p70 S6 kinase. Inactivation by either kinase resulted from the phosphorylation of Ser‐21 and was reversed by treatment with protein phosphatase 2A1 ...
C. Sutherland, P. Cohen
semanticscholar   +5 more sources

Structure-based identification of potential inhibitors of ribosomal protein S6 kinase 1, targeting cancer therapy: a combined docking and molecular dynamics simulations approach

Journal of Biomolecular Structure and Dynamics, 2023
Ribosomal protein S6 kinase 1 (S6K1), commonly known as P70-S6 kinase 1 (p70S6), is a key protein kinase involved in cellular signaling pathways that regulate cell growth, proliferation, and metabolism.
A. Alam, Mohammad Shahzeb Khan, Yash Mathur, Md Nayab Sulaimani, Naqiya Farooqui, S. Ahmad, A. Nadeem, D. K. Yadav, Taj Mohammad   +8 more
semanticscholar   +1 more source

Interferon regulatory factor 1 eliminates mycobacteria by suppressing p70 S6 kinase via mechanistic target of rapamycin signaling

Journal of Infection, 2019
Although it has been reported that Interferon regulatory factor 1 (IRF1) inhibits Mycobacterium tuberculosis (Mtb) infection via inducible nitric oxide synthase (iNOS) in mice, how it counteracts with mycobacterial infection in human remains largely obscure.
Linmiao Lie, Xinying Zhou, Qiuwei Pan, Li Ma, Lei Xu, Shengfeng Hu, Xialin Du, Lijie Zhang, Zelin Zhang, Yanfen Li, Honglin Liu, Jiahui Yang, Ruining Wang, Yingqi Huang, Qian Wen, Yuchi Gao, Bo Zhu, Chaoying Zhou   +17 more
openaire   +3 more sources

Angiopoietin-1 reduces iopromide-induced endothelial cell apoptosis through activation of phosphatidylinositol 3'-kinase/p70 S6 kinase.

International journal of tissue reactions, 2006
Radiocontrast media can induce vascular endothelial cell apoptosis. Apoptotic damage to the vascular endothelium is an important mechanism in vascular disease. Several growth factors with anti-apoptotic effects may help protect the vascular endothelium from apoptosis.
S O, Moon, W, Kim, D H, Kim, M J, Sung, S, Lee, K P, Kang, A S, Yi, K Y, Jang, S Y, Lee, S K, Park   +9 more
openaire   +2 more sources

Involvement of adenylate cyclase and p70 S6 -kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1

Pfl�gers Archiv European Journal of Physiology, 1999
Our previous results show that recombinant gp41 (aa565-647), the extracellular domain of HIV-1 transmembrane glycoprotein, stimulates interleukin-10 (IL-10) production in human monocytes. The signal cascade transducing this effect is not yet clear.
M. P. Dierich, Heribert Stoiber, Maria Barcova, Florian Überall, Laco Kacani, Cornelia Speth   +5 more
openaire   +3 more sources