Low-scale phosphoproteome analyses identify the mTOR effector p70 S6 kinase 1 as a specific biomarker of the dual-HER1/HER2 tyrosine kinase inhibitor lapatinib (Tykerb) in human breast carcinoma cells. [PDF]
Annals of Oncology, 2008 BACKGROUND Discovery of key proliferative and/or survival cascades closely linked to the biological effects of human epidermal growth factor receptor (HER) 1 (erbB-1) and/or HER2 (erbB-2) inhibitors may identify a priori mechanisms responsible for the ...
A. Vazquez-Martin +4 more
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Negative regulation of melanogenesis by phospholipase D1 through mTOR/p70 S6 kinase 1 signaling in mouse B16 melanoma cells [PDF]
Journal of Cellular Physiology, 2005 AbstractMelanogenesis is a principal parameter of differentiation in melanocytes and melanoma cells. Our recent study has demonstrated that phospholipase D1 (PLD1) regulates the melanogenic signaling through modulating the expression of tyrosinase, the rate‐limiting step enzyme in the melanin biosynthesis.
K. Ohguchi +4 more
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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro [PDF]
Current Biology, 1998 The p70 S6 kinase, an enzyme critical for cell-cycle progression through the G1 phase, is activated in vivo by insulin and mitogens through coordinate phosphorylation at multiple sites, regulated by signaling pathways, some of which depend on and some of which are independent of phosphoinositide 3-kinase (Pl 3-kinase).
D. Alessi +4 more
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S6 kinase 1 at the central node of cell size and ageing
Frontiers in Cell and Developmental Biology, 2022 Genetic evidence in living organisms from yeast to plants and animals, including humans, unquestionably identifies the Target Of Rapamycin kinase (TOR or mTOR for mammalian/mechanistic) signal transduction pathway as a master regulator of growth through ...
Stefano Fumagalli, Mario Pende
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Role of adenosine monophosphate‐activated protein kinase–p70 ribosomal S6 kinase‐1 pathway in repression of liver X receptor‐alpha–dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones [PDF]
Hepatology, 2009 Dithiolethiones, a novel class of adenosine monophosphate‐activated protein kinase (AMPK) activators, prevent insulin resistance through AMPK‐dependent p70 ribosomal S6 kinase‐1 (S6K1) inhibition.
Seong Hwan Hwahng +4 more
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Structural Basis of Human p70 Ribosomal S6 Kinase-1 Regulation by Activation Loop Phosphorylation [PDF]
Journal of Biological Chemistry, 2009 p70 ribosomal S6 kinase (p70S6K) is a downstream effector of the mTOR signaling pathway involved in cell proliferation, cell growth, cell-cycle progression, and glucose homeostasis.
T. Sunami +14 more
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Constitutive activation of the Src-family kinases Fgr and Hck enhances the tumor burden of acute myeloid leukemia cells in immunocompromised mice [PDF]
Scientific ReportsOverexpression of the myeloid Src-family kinases Fgr and Hck has been linked to the development of acute myeloid leukemia (AML). Here we characterized the contribution of active forms of these kinases to AML cell cytokine dependence, inhibitor ...
Sherry T. Shu +3 more
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Cyclin-dependent Kinase 5 (Cdk5)-dependent Phosphorylation of p70 Ribosomal S6 Kinase 1 (S6K) Is Required for Dendritic Spine Morphogenesis* [PDF]
Journal of Biological Chemistry, 2015 Background: The signaling protein S6K undergoes phosphorylation at multiple serine/threonine sites, but the functional significance is unknown. Results: Cdk5 phosphorylates S6K at Ser-411 in neuron, and loss of this phosphorylation event reduces the ...
Kwok-On Lai +4 more
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Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex. [PDF]
Biochemical Journal, 2003 The mitogen-stimulated protein kinase p70 ribosomal protein S6 kinase 1 (S6K1) is a key enzyme in the regulation of cell growth and proliferation.
K. Hannan, G. Thomas, R. Pearson
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