Rictor is a novel target of p70 S6 kinase-1 [PDF]
Oncogene, 2009 The rapamycin-insensitive companion of mammalian target of rapamycin (mTOR) (Rictor) is a key member of mTOR complex-2 (mTORC2), which phosphorylates the AGC kinases Akt/PKB, PKC and SGK1 at a C-terminal hydrophobic motif. We identified several novel sites on Rictor that are phosphorylated, including Thr1135, which is conserved across all vertebrates ...
C, Treins +4 more
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Hepatology, EarlyView., 2022 A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan +19 more
wiley +1 more source
Activation of a novel p70 S6 kinase 1-dependent intracellular cascade in the basolateral nucleus of the amygdala is required for the acquisition of extinction memory. [PDF]
Mol Psychiatry, 2018 Repeated presentations of a previously conditioned stimulus lead to a new form of learning known as extinction, which temporarily alters the response to the original stimulus. Previous studies have shown that the consolidation of extinction memory requires de novo protein synthesis.
Huynh TN +10 more
europepmc +4 more sources
Decorin Deficiency Promotes D-Galactose-Induced Skeletal Muscle Atrophy and Fibrosis by Regulating ITGB1/Akt/mTOR Signalling Pathway. [PDF]
J Cachexia Sarcopenia MuscleABSTRACT Background Primary sarcopenia is an age‐associated disorder with progressive and generalised loss of skeletal muscle strength and mass. Skeletal muscle fibrosis is one of the significant pathological manifestations of age‐associated sarcopenia. Decorin, a small dermatan–sulfate proteoglycan, participates in extracellular matrix assembly.
Luo X +9 more
europepmc +2 more sources
Characterization of p70 S6 kinase 1 in early development of mouse embryos [PDF]
Developmental Dynamics, 2009 AbstractThe mTOR kinase controls cell growth, proliferation, and survival through two distinct multiprotein complexes mTORC1 and mTORC2. p70 S6 Kinase 1 (S6K1) is characterized as downstream effector of mTOR. Until recently, the connection between S6K1 and mTORC1 /mTORC2 during the early development of mouse embryos has not been well elucidated.
Xiao-Yan, Xu +7 more
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Oncogenic Raf-1 Activates p70 S6 Kinase via a Mitogen-activated Protein Kinase-independent Pathway [PDF]
Journal of Biological Chemistry, 1996 Cell proliferation requires the co-ordinate triggering of several protein kinases of Ser/Thr specificity such as p70 S6 kinase (S6K), which phosphorylates the ribosomal S6 protein and thus increases translation of mRNAs with polypyrimidine tracts. The multiplicity of signaling pathways leading to p70 S6K activation are not fully elucidated.
P, Lenormand, M, McMahon, J, Pouysségur
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Retraction: Targeting 3-Phosphoinoside-Dependent Kinase-1 to Inhibit Insulin-Like Growth Factor-I Induced AKT and p70 S6 Kinase Activation in Breast Cancer Cells. [PDF]
PLoS ONE, 2017 PLOS ONE Editors
doaj +4 more sources
Comparison of the specificities of p70 S6 kinase and MAPKAP kinase‐1 identifies a relatively specific substrate for p70 S6 kinase: the N‐terminal kinase domain of MAPKAP kinase‐1 is essential for peptide phosphorylation [PDF]
FEBS Letters, 1995 xxR/KxRxxSxx sequences were phosphorylated with high efficiency by both p70 S6 kinase (p70S6K) and MAPKAP kinase‐1. The best substrate for MAPKAP kinase‐1 (KKKNRTLSVA) was phosphorylated with a K m of 0.17 μM, and the best substrate for p70S6K (KKRNRTLSVA) with a K m of 1.5 μM.
Leighton, Ian A. +4 more
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Insulin Stimulation of Protein Synthesis and mTOR Signaling in Chick Myotube Cultures
The Journal of Poultry Science, 2020 Insulin stimulates protein synthesis in skeletal muscles. Protein synthesis is controlled by the mechanistic target of rapamycin (mTOR) signaling in skeletal muscles.
Kazuki Nakashima +4 more
doaj +1 more source
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase [PDF]
FEBS Letters, 1996 The substrate specificity of protein kinase‐Bα (PKBα, also known as RAC kinase or Akt) was investigated using synthetic peptide substrates related to the sequence surrounding the phosphorylation site on glycogen synthase kinase‐3 (GSK3). The minimum sequence motif required for efficient phosphorylation was Arg‐Xaa‐Arg‐Yaa‐Zaa‐Ser/Thr‐Hyd, where Xaa is ...
Alessi, Dario R. +4 more
openaire +3 more sources