Retraction: Targeting 3-Phosphoinoside-Dependent Kinase-1 to Inhibit Insulin-Like Growth Factor-I Induced AKT and p70 S6 Kinase Activation in Breast Cancer Cells. [PDF]
PLoS ONE, 2017 PLOS ONE Editors
doaj +5 more sources
Frontiers in Pharmacology, 2022 Mechanistic target of rapamycin (mTOR) C1 and its downstream effectors have been implicated in synaptic plasticity and memory. Our prior work demonstrated that reactivation of cocaine memory engages a signaling pathway consisting of Akt, glycogen ...
Xiangdang Shi +7 more
doaj +2 more sources
Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1)* [PDF]
Journal of Biological Chemistry, 2011 p70 ribosomal protein S6 kinase 1 (S6K1) is regulated by multiple phosphorylation events. Three of these sites are highly conserved among AGC kinases (cAMP dependent Protein Kinase, cGMP dependent Protein Kinase, and Protein Kinase C subfamily): the ...
Malik M. Keshwani +4 more
semanticscholar +2 more sources
Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1. [PDF]
American Journal of Respiratory Cell and Molecular Biology, 2006 We have previously found that both mitogen-activated protein kinase (MAPK)- and Rho kinase (ROCK)-related signaling pathways are necessary for the induction of pulmonary artery smooth muscle cell (SMC) proliferation by serotonin (5-hydroxytryptamine [5 ...
Yingling Liu, B. Fanburg
semanticscholar +2 more sources
Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates [PDF]
Cell Death & Disease, 2018 Autophagy plays a central role in degrading misfolded proteins such as mutated superoxide dismutase 1 (SOD1), which forms aggregates in motor neurons and is involved in the pathogenesis of amyotrophic lateral sclerosis (ALS).
Jing Sun +10 more
semanticscholar +4 more sources
Differential Regulation of the Phosphatidylinositol 3-Kinase/Akt and p70 S6 Kinase Pathways by the α1A-Adrenergic Receptor in Rat-1 Fibroblasts [PDF]
Journal of Biological Chemistry, 2000 Phosphatidylinositol (PI) 3-kinase and its downstream effector Akt are thought to be signaling intermediates that link cell surface receptors to p70 S6 kinase. We examined the effect of a G(q)-coupled receptor on PI 3-kinase/Akt signaling and p70 S6 kinase activation using Rat-1 fibroblasts stably expressing the human alpha(1A)-adrenergic receptor ...
Lisa M. Ballou +5 more
openalex +5 more sources
Supplementary Table 1 from p70 S6 Kinase Promotes Epithelial to Mesenchymal Transition through Snail Induction in Ovarian Cancer Cells [PDF]
, 2023 Supplementary Table 1 from p70 S6 Kinase Promotes Epithelial to Mesenchymal Transition through Snail Induction in Ovarian Cancer ...
Yuen L. Pon +4 more
+4 more sources
Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate–activated protein kinase–p70 ribosomal S6 kinase‐1 pathway [PDF]
Hepatology, 2007 Eun Ju Bae +3 more
semanticscholar +2 more sources
Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1 [PDF]
Journal of Biological Chemistry, 2007 Adiponectin functions as an insulin sensitizer, and yet the underlying molecular mechanism(s) remains largely unknown. We found that treating C2C12 myotubes with adiponectin or rapamycin enhanced the ability of insulin to stimulate IRS-1 tyrosine phosphorylation and Akt phosphorylation, concurrently with reduced p70 S6 kinase phosphorylation at Thr389 ...
Changhua Wang +7 more
openalex +4 more sources
Supplementary Figure Legends 1-2 from p70 S6 Kinase Promotes Epithelial to Mesenchymal Transition through Snail Induction in Ovarian Cancer Cells [PDF]
, 2023 Supplementary Figure Legends 1-2 from p70 S6 Kinase Promotes Epithelial to Mesenchymal Transition through Snail Induction in Ovarian Cancer ...
Yuen L. Pon +4 more
+4 more sources