Results 31 to 40 of about 20,664 (187)

Protective effects of glucagon‐like peptide‐1 on cardiac remodeling by inhibiting oxidative stress through mammalian target of rapamycin complex 1/p70 ribosomal protein S6 kinase pathway in diabetes mellitus

Journal of Diabetes Investigation, 2020
Aims/Introduction Although increased reactive oxygen species (ROS) generation is a major mechanism leading to cardiac remodeling in diabetes mellitus, research into the effects of anti‐oxidation on diabetic cardiac remodeling remains scarce and ...
Dongjuan Wang, Longfu Jiang, Beili Feng, Nana He, Yue Zhang, Honghua Ye   +5 more
doaj   +1 more source

Phosphorylation of IRS1 at serine 307 in response to insulin in human adipocytes is not likely to be catalyzed by p70 ribosomal S6 kinase. [PDF]

PLoS ONE, 2013
The insulin receptor substrate-1 (IRS1) is phosphorylated on serine 307 (human sequence, corresponding to murine serine 302) in response to insulin as part of a feedback loop that controls IRS1 phosphorylation on tyrosine residues by the insulin receptor.
Meenu Rohini Rajan, Siri Fagerholm, Cecilia Jönsson, Preben Kjølhede, Maria V Turkina, Peter Strålfors   +5 more
doaj   +1 more source

Dissociation of the mTOR Protein Interaction Network Following Neuronal Activation Is Altered by Shank3 Mutation. [PDF]

J Neurochem
Neurons encode activity through precise, stimulus‐dependent rearrangements of protein interaction networks, including the mTOR signaling cascade. Using multiplex co‐immunoprecipitation in primary cortical neurons, we show that IGF1, glutamate, and homeostatic up‐ or down‐scaling with Tetrodotoxin (TTX) or Bicuculline (BIC), respectively, each induce ...
Wehle DT, Brown EA, Stamenkovic V, Gniffen B, Harsh FM, Smith SEP.   +5 more
europepmc   +2 more sources

Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1 [PDF]

Journal of Biological Chemistry, 2007
Adiponectin functions as an insulin sensitizer, and yet the underlying molecular mechanism(s) remains largely unknown. We found that treating C2C12 myotubes with adiponectin or rapamycin enhanced the ability of insulin to stimulate IRS-1 tyrosine phosphorylation and Akt phosphorylation, concurrently with reduced p70 S6 kinase phosphorylation at Thr389 ...
Changhua, Wang, Xuming, Mao, Lixin, Wang, Meilian, Liu, Michael D, Wetzel, Kun-Liang, Guan, Lily Q, Dong, Feng, Liu   +7 more
openaire   +2 more sources

Regulation of autophagy in chick myotube cultures: Effect of uncoupling mitochondrial oxidative phosphorylation

The Journal of Poultry Science, 2023
s: Skeletal muscles have a high demand for ATP, which is met largely through mitochondria oxidative phosphorylation. Autophagy is essential for the maintenance of skeletal muscle mass under catabolic conditions.
Kazuki Nakashima, Aiko Ishida
doaj   +1 more source

TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G₁ arrest [PDF]

Genes & Development, 2000
On TGF-β binding, the TGF-β receptor directly phosphorylates and activates the transcription factors Smad2/3, leading to G1 arrest. Here, we present evidence for a second, parallel, TGF-β-dependent pathway for cell cycle arrest, achieved via inhibition of p70s6k.
C, Petritsch, H, Beug, A, Balmain, M, Oft   +3 more
openaire   +2 more sources

S6 kinase 1 at the central node of cell size and ageing

Frontiers in Cell and Developmental Biology, 2022
Genetic evidence in living organisms from yeast to plants and animals, including humans, unquestionably identifies the Target Of Rapamycin kinase (TOR or mTOR for mammalian/mechanistic) signal transduction pathway as a master regulator of growth through ...
Stefano Fumagalli, Mario Pende
doaj   +1 more source

Characterization of Phosphatidylinositol 3-Kinase-dependent Phosphorylation of the Hydrophobic Motif Site Thr389 in p70 S6 Kinase 1 [PDF]

Journal of Biological Chemistry, 2002
Phosphorylation of the highly conserved hydrophobic motif site in AGC kinases is necessary for phosphotransferase activity. Phosphorylation of this motif (FLGFT389Y) in p70 S6 kinase (S6K1) is both rapamycin- and wortmannin-sensitive, suggesting a role for both mammalian target of rapamycin- and phosphatidylinositol 3-kinase-dependent pathways.
Angela, Romanelli, Valley C, Dreisbach, John, Blenis   +2 more
openaire   +2 more sources

Senescent Cells Involved in Deterioration of Bone Microstructure by High-Frequency Parathyroid Hormone 1-34 Administration and Bone Loss. [PDF]

Aging Cell
Senescent osteoblasts induced by PTH contribute to cortical bone loss in aged mice. Senolytic co‐treatment reduces senescence and prevents bone loss after PTH withdrawal, enhancing the durability of osteoporosis therapy. ABSTRACT Osteoporosis is characterized by reduced bone mass and structural deterioration, leading to increased fracture risk ...
Bun M, Ukon Y, Ikuta M, Kitahara T, Furuichi T, Hirai H, Tateiwa D, Kanie Y, Furuya M, Fujimori T, Otsuru S, Okada S, Kaito T.   +12 more
europepmc   +2 more sources

Distinct signalling pathways mediate insulin and phorbol ester- stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells [PDF]

, 2000
Stimulation of serum-starved human embryonic kidney (HEK) 293 cells with either the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), or insulin resulted in increases in the phosphorylation of 4E-BP1 and p70 S6 kinase, eIF4F assembly, and ...
Alessi, Alessi, Alessi, Beretta, Brostrom, Brunn, Burgering, Burnett, Cheatham, Chung, Cross, Dudley, Dufner, Favata, Flynn, Fukunaga, Gingras, Gingras, Haghighat, Hara, Haystead, Huang, Jefferies, Kitamura, Kleijn, Kohn, Kohn, Lamphear, Lin, Lin, Manzella, Marcotrigiano, Mendez, Monfar, Morley, Morley, Morley, Morris, Mukhopadhyay, Nave, Nissley, Pause, Petritsch, Polakiewicz, Price, Proud, Ptushkina, Pyronnet, Pyronnet, Rao, Rasmussen, Rau, Schonwasser, Scott, Scott, Sonenberg, Stokoe, Terada, Ueki, von Manteuffel, Vries, Wang, Waskiewicz, Waskiewicz   +63 more
core   +1 more source