Extinction of auditory threat memory triggers activation of p70 S6 kinase 1 in the basolateral nucleus of the amygdala [PDF]
Molecular Psychiatry, 2018 Extinction of auditory threat memory triggers activation of p70 S6 kinase 1 in the basolateral nucleus of the ...
T. N. Huynh +10 more
semanticscholar +3 more sources
Genistein sensitizes hepatic insulin signaling and modulates lipid regulatory genes through p70 ribosomal S6 kinase-1 inhibition in high-fat–high-fructose diet-fed mice [PDF]
Pharmaceutical Biology, 2013 E. Arunkumar +2 more
semanticscholar +2 more sources
TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G1 arrest [PDF]
Genes & Development, 2000 On TGF-β binding, the TGF-β receptor directly phosphorylates and activates the transcription factors Smad2/3, leading to G1 arrest. Here, we present evidence for a second, parallel, TGF-β-dependent pathway for cell cycle arrest, achieved via inhibition of p70s6k.
Claudia Petritsch +3 more
openalex +4 more sources
Comparison of the specificities of p70 S6 kinase and MAPKAP kinase‐1 identifies a relatively specific substrate for p70 S6 kinase: the N‐terminal kinase domain of MAPKAP kinase‐1 is essential for peptide phosphorylation [PDF]
FEBS Letters, 1995 xxR/KxRxxSxx sequences were phosphorylated with high efficiency by both p70 S6 kinase (p70S6K) and MAPKAP kinase‐1. The best substrate for MAPKAP kinase‐1 (KKKNRTLSVA) was phosphorylated with a K m of 0.17 μM, and the best substrate for p70S6K (KKRNRTLSVA) with a K m of 1.5 μM.
I. Leighton +4 more
semanticscholar +5 more sources
Stimulation of protein kinase B and p70 S6 kinase by the histamine H1 receptor in DDT1MF‐2 smooth muscle cells [PDF]
British Journal of Pharmacology, 2002 Previous studies have shown that the histamine H1 receptor activates p42/p44 mitogen‐activated protein kinases (MAPK) in DDT1MF‐2 smooth muscle cells via a phosphatidylinositol 3‐kinase (PI‐3K)‐dependent pathway. In this study the effect of histamine H1 receptor stimulation on protein kinase B (PKB) and p70 S6 kinase, both of which are downstream ...
John M. Dickenson
openalex +5 more sources
Supplementary Figure 1 from p70 S6 Kinase Promotes Epithelial to Mesenchymal Transition through Snail Induction in Ovarian Cancer Cells [PDF]
, 2023 Supplementary Figure 1 from p70 S6 Kinase Promotes Epithelial to Mesenchymal Transition through Snail Induction in Ovarian Cancer ...
Yuen L. Pon +4 more
+4 more sources
Hepatology, EarlyView., 2022 A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan +19 more
wiley +1 more source
p60-S6K1 represents a novel kinase active isoform with the mode of regulation distinct from p70/p85-S6K1 isoforms [PDF]
The Ukrainian Biochemical Journal, 2019 The phosphatidylinositol-3-kinase (PI3K)/mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway controls plenty of cellular functions regulating phosphorylation one of its mediators ribosomal protein S6 kinase 1 (S6K1).
I. V. Zaiets +4 more
doaj +1 more source
The Journal of Poultry Science, 2022 Protein synthesis in skeletal muscle is considered one of the most energy-consuming cellular processes. AMP-activated protein kinase (AMPK) is a metabolic master switch that regulates glucose and lipid metabolism, and it is implicated in protein ...
Kazuki Nakashima, Aiko Ishida
doaj +1 more source
Molecular Characterization and Expression Analysis of S6K1 in Cashmere Goats () [PDF]
Asian-Australasian Journal of Animal Sciences, 2013 p70 ribosomal S6 kinase (p70S6K) can integrate nutrient and growth factor signals to promote cell growth and survival. We report our molecular characterization of the complementary DNA (cDNA) that encodes the goat p70S6K gene 40S ribosomal S6 kinase 1 ...
Wu Manlin +5 more
doaj +1 more source