Results 51 to 60 of about 20,664 (187)

Mechanistic target of rapamycin (mTOR) signaling genes in decapod crustaceans: cloning and tissue expression of mTOR, Akt, Rheb, and S6 kinase in the green crab, Carcinus maenas, and blackback land crab, Gecarcinus lateralis [PDF]

, 2014
Mechanistic target of rapamycin (mTOR) controls global translation of mRNA into protein by phosphorylating p70 S6 kinase (S6K) and eIF4E-binding protein-1. Akt and Rheb, a GTP-binding protein, regulate mTOR protein kinase activity. Molting in crustaceans
Abuhagr, Ali M., Chang, Ernest S., MacLea, Kyle S., Mykles, Donald L.   +3 more
core   +2 more sources

Insulin utilizes the PI 3-kinase pathway to inhibit SP-A gene expression in lung epithelial cells

Respiratory Research, 2002
Background It has been proposed that high insulin levels may cause delayed lung development in the fetuses of diabetic mothers. A key event in lung development is the production of adequate amounts of pulmonary surfactant. Insulin inhibits the expression
Snyder Jeanne M, Goss Kelli L, Miakotina Olga L   +2 more
doaj   +1 more source

Investigating the effect of target of rapamycin kinase inhibition on the Chlamydomonas reinhardtii phosphoproteome: from known homologs to new targets [PDF]

, 2019
Recuperado de: https://www.biorxiv.org/content/10.1101/310102v1Target of rapamycin (TOR) kinase is a conserved regulator of cell growth whose activity is modulated in response to nutrients, energy and stress.
Couso Liáñez, Inmaculada Concepción, Crespo González, José Luis, Hicks, Leslie, McConnell, Evan W., Perrine, Zoee, Umen, James G., Werth, Emily G.   +6 more
core   +1 more source

Phosphatidic Acid Regulates Systemic Inflammatory Responses by Modulating the Akt-Mammalian Target of Rapamycin-p70 S6 Kinase 1 Pathway [PDF]

Journal of Biological Chemistry, 2003
Macrophages are pivotal effector cells in the innate immune system. When microbial products bind to pathogen recognition receptors, macrophages are activated and release a broad array of mediators, such as cytokines, that orchestrate the inflammatory responses of the host.
Lim, HK, Choi, YA, Park, W, Lee, T, Ryu, SH, Kim, SY, Kim, JR, Kim, JH, Baek, SH   +8 more
openaire   +3 more sources

Variability of protein level and phosphorylation status caused by biopsy protocol design in human skeletal muscle analyses

BMC Research Notes, 2011
Background Bergström needle biopsy is widely used to sample skeletal muscle in order to study cell signaling directly in human tissue. Consequences of the biopsy protocol design on muscle protein quantity and quality remain unclear.
Caron Marc-André, Charette Steve J, Maltais François, Debigaré Richard   +3 more
doaj   +1 more source

The Р60-S6K1 isoform of ribosomal protein S6 kinase 1 is a product of alternative mRNA translation

The Ukrainian Biochemical Journal, 2018
Ribosomal protein S6 kinase 1 (S6K1) is a well-known downstream effector of mTORC1 (mechanistic target of rapamycin complex 1) participating primarily in the regulation of cell growth and metabolism.
I. V. Zaiets, A. S. Sivchenko, A. I. Khoruzhenko, L. O. Savinska, V. V. Filonenko   +4 more
doaj   +1 more source

Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors [PDF]

, 2014
Ribosome biogenesis is a key process for maintaining protein synthetic capacity in dividing or growing cells, and requires coordinated production of ribosomal proteins and ribosomal RNA (rRNA), including the processing of the latter.
Arora, Baird, Beugnet, Boultwood, Brandenburger, Brenneisen, Browne, Chresta, Christopher G. Proud, Dong, Drygin, Dunlop, Feldman, Fonseca, Fonseca, Fumagalli, Gingras, Grimm, Hannan, Hara, Holzel, Horn, Horos, Huang, Iadevaia, Iadevaia, Jastrzebski, Jefferies, Julien Averous, Killian, Kimball, Kispal, Lam, Le-Bacquer, Lempiainen, Lempiainen, Loreni, Mayer, Mayer, Meyuhas, Miluzio, Montanaro, Oshiro, Patursky-Polischuk, Pearce, Pearson, Peter M. Taylor, Pianese, Popowski, Proud, Redpath, Rodnina, Rohrmoser, Rui Liu, Sancak, Sancak, Sanchez, Sarbassov, Smith, Strezoska, Strezoska, Thoreen, Valentina Iadevaia, Wang, Wang, Willett, Xiao, Yip, Ze Zhang   +68 more
core   +6 more sources

Differential Regulation of the Phosphatidylinositol 3-Kinase/Akt and p70 S6 Kinase Pathways by the α1A-Adrenergic Receptor in Rat-1 Fibroblasts [PDF]

Journal of Biological Chemistry, 2000
Phosphatidylinositol (PI) 3-kinase and its downstream effector Akt are thought to be signaling intermediates that link cell surface receptors to p70 S6 kinase. We examined the effect of a G(q)-coupled receptor on PI 3-kinase/Akt signaling and p70 S6 kinase activation using Rat-1 fibroblasts stably expressing the human alpha(1A)-adrenergic receptor ...
L M, Ballou, M E, Cross, S, Huang, E M, McReynolds, B X, Zhang, R Z, Lin   +5 more
openaire   +2 more sources

FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity. [PDF]

PLoS ONE, 2014
Hyperactive mammalian target of rapamycin (mTOR) is associated with cognitive deficits in several neurological disorders including tuberous sclerosis complex (TSC). The phosphorylation of the mRNA-binding protein FMRP reportedly depends on mTOR complex 1
Christopher M Bartley, Rachel A O'Keefe, Angélique Bordey   +2 more
doaj   +1 more source

Blue light impairs cornea and corneal wound healing by downregulating VCAM1 partly

iScience, 2023
Summary: This study aimed to investigate the effects of long-term pollution from different wavelengths of light on the corneal epithelium (CE) and identify potential biomarkers. Rabbits were exposed to red, green, blue, white, and environmental light for
Kuangqi Chen, Le Jin, Yingying Wen, Qianjie Yang, Xiang Li, Liyue Zhang, Liyin Wang, Yutong Xia, Zhitong Chen, Chen Xie, Jianping Tong, Ye Shen   +11 more
doaj   +1 more source