Results 71 to 80 of about 24,655 (236)

The Р60-S6K1 isoform of ribosomal protein S6 kinase 1 is a product of alternative mRNA translation

The Ukrainian Biochemical Journal, 2018
Ribosomal protein S6 kinase 1 (S6K1) is a well-known downstream effector of mTORC1 (mechanistic target of rapamycin complex 1) participating primarily in the regulation of cell growth and metabolism.
I. V. Zaiets, A. S. Sivchenko, A. I. Khoruzhenko, L. O. Savinska, V. V. Filonenko   +4 more
doaj   +1 more source

FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity. [PDF]

PLoS ONE, 2014
Hyperactive mammalian target of rapamycin (mTOR) is associated with cognitive deficits in several neurological disorders including tuberous sclerosis complex (TSC). The phosphorylation of the mRNA-binding protein FMRP reportedly depends on mTOR complex 1
Christopher M Bartley, Rachel A O'Keefe, Angélique Bordey   +2 more
doaj   +1 more source

In vivo E2F reporting reveals efficacious schedules of MEK1/2–CDK4/6 targeting and mTOR–s6 resistance mechanisms [PDF]

, 2018
Targeting cyclin-dependent kinases 4/6 (CDK4/6) represents a therapeutic option in combination with BRAF inhibitor and/or MEK inhibitor (MEKi) in melanoma; however, continuous dosing elicits toxicities in patients. Using quantitative and temporal in vivo
Aplin, Andrew E., Cheng, Phil F., Chervoneva, Inna, Davies, Michael A., Dummer, Reinhard, Ertel, Adam, Fortina, Paolo, Hookim, Kim, Kleiber, Ines, Kwong, Lawrence N., Levesque, Mitch P., Nikbakht, Neda, Patel, Prem, Purwin, Timothy J., Teh, Jessica L. F.   +14 more
core   +1 more source

MTORC1 signaling and regulation of pancreatic β-cell mass [PDF]

, 2012
The capacity of β cells to expand in response to insulin resistance is a critical factor in the development of type 2 diabetes. Proliferation of β cells is a major component for these adaptive responses in animal models.
Alejandro, Emilyn U, Bernal-Mizrachi, Ernesto, Blandino-Rosano, Manuel, Chen, Angela Y, Cras-Meneur, Corentin, Elghazi, Lynda, Gould, Aaron P, Scheys, Joshua O, Taranukha, Tatyana   +8 more
core   +2 more sources

Impaired Phosphorylation and Ubiquitination by p70 S6 Kinase (p70S6K) and Smad Ubiquitination Regulatory Factor 1 (Smurf1) Promote Tribbles Homolog 2 (TRIB2) Stability and Carcinogenic Property in Liver Cancer [PDF]

Journal of Biological Chemistry, 2013
Tribbles homolog 2 (TRIB2) is critical for both solid and non-solid malignancies. Recently, TRIB2 was identified as a liver cancer-specific Wnt/β-catenin signaling downstream target and is functionally important for liver cancer cell survival and transformation. TRIB2 functions as a protein that interacts with E3 ubiquitin ligases and thereby modulates
Jiayi Wang, Yue Zhang, Wenhao Weng, Yongxia Qiao, Lifang Ma, Weifan Xiao, Yongchun Yu, Qiuhui Pan, Fenyong Sun   +8 more
openalex   +5 more sources

The Strong Antioxidant Sheep/Goat Whey Protein Protects Against mTOR Overactivation in Rats: A Mode of Action Mimicking Fasting

Antioxidants, 2019
Whey protein, a by-product of the cheese industry, can be putatively used as a functional food due to its beneficial health properties. The main objective of the present study was to assess in vivo the effect of a sheep/goat whey protein on the plasma ...
Efthalia Kerasioti, Aristidis Veskoukis, Christina Virgiliou, Georgios Theodoridis, Ioannis Taitzoglou, Dimitrios Kouretas   +5 more
doaj   +1 more source

Cytokine-associated drug toxicity in human hepatocytes is associated signaling network dysregulation [PDF]

, 2009
Refer to Web version on PubMed Central for supplementary material.Idiosyncratic drug hepatotoxicity is a major problem in pharmaceutical development due to poor prediction capability of standard preclinical toxicity assessments and limited knowledge of ...
Ballif, Bart S. Hendriks, Benjamin D. Cosgrove, Bylesjö, Chokki, Clayton, Cosgrove, Cosgrove, Deng, Deng, Deng, Douglas A. Lauffenburger, Fielden, Ganey, Gaudet, Geladi, Gunawan, Hatano, Hotamisligil, Janes, Janes, Janes, Janes, Kaplowitz, Kaplowitz, Kemp, Kim, Kolls, Kumar, Kumar, Le, Lee, Leonidas G. Alexopoulos, Linda G. Griffith, Malhi, McCubrey, Miller-Jensen, Ono, Peter K. Sorger, Saez-Rodriguez, Sarbassov, Schwabe, Shaw, Ta-chun Hang, Tacke, Tukov, Wajant, Wold, Xu, Xu, Yuan   +50 more
core   +1 more source

The order of concurrent training affects mTOR signaling but not mitochondrial biogenesis in mouse skeletal muscle

Physiological Reports, 2020
Concurrent training involves a combination of two different modes of training. In this study, we conducted an experiment by combining resistance and endurance training. The purpose of this study was to investigate the influence of the order of concurrent
Takanaga Shirai, Yuki Aoki, Kohei Takeda, Tohru Takemasa   +3 more
doaj   +1 more source

Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms. [PDF]

PLoS ONE, 2014
We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in turn improving glucose ...
Christopher J Lelliott, Andrea Ahnmark, Therese Admyre, Ingela Ahlstedt, Lorraine Irving, Feenagh Keyes, Laurel Patterson, Michael B Mumphrey, Mikael Bjursell, Tracy Gorman, Mohammad Bohlooly-Y, Andrew Buchanan, Paula Harrison, Tristan Vaughan, Hans-Rudolf Berthoud, Daniel Lindén   +15 more
doaj   +1 more source

Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]

, 2002
International ...
Burdon, Tom, Savatier, Pierre, Smith, Austin   +2 more
core   +1 more source