Results 81 to 90 of about 24,655 (236)

PCI-24781 down-regulates EZH2 expression and then promotes glioma apoptosis by suppressing the PIK3K/Akt/mTOR pathway [PDF]

Genetics and Molecular Biology, 2014
PCI-24781 is a novel histone deacetylase inhibitor that inhibits tumor proliferation and promotes cell apoptosis. However, it is unclear whether PCI-24781 inhibits Enhancer of Zeste 2 (EZH2) expression in malignant gliomas.
Wei Zhang, Shengqing Lv, Jun Liu, Zhenle Zang, Junyi Yin, Ning An, Hui Yang, Yechun Song   +7 more
doaj   +3 more sources

Mechanistic target of rapamycin (mTOR) signaling genes in decapod crustaceans: cloning and tissue expression of mTOR, Akt, Rheb, and S6 kinase in the green crab, Carcinus maenas, and blackback land crab, Gecarcinus lateralis [PDF]

, 2014
Mechanistic target of rapamycin (mTOR) controls global translation of mRNA into protein by phosphorylating p70 S6 kinase (S6K) and eIF4E-binding protein-1. Akt and Rheb, a GTP-binding protein, regulate mTOR protein kinase activity. Molting in crustaceans
Abuhagr, Ali M., Chang, Ernest S., MacLea, Kyle S., Mykles, Donald L.   +3 more
core   +2 more sources

Metformin Induces Autophagy via the AMPK-mTOR Signaling Pathway in Human Hepatocellular Carcinoma Cells

Cancer Management and Research, 2020
Chun Gao,1 Long Fang,1 Hui Zhang,2 Wei-Shuo Zhang,1 Xiao-Ou Li,1 Shi-Yu Du1 1Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, People’s Republic of China; 2Department of Gastroenterology, Beijing Tiantan Hospital ...
Gao C, Fang L, Zhang H, Zhang WS, Li XO, Du SY   +5 more
doaj  

SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress [PDF]

, 2014
SIRT1, an NAD-dependent deacetylase, plays a role in regulation of autophagy. SIRT1 increases mitochondrial function and reduces oxidative stress, and has been linked to age-related reactive oxygen species (ROS) generation, which is highly dependent on ...
Broxmeyer, Hal E., Huang, Xinxin, Lee, Man Ryul, Messina-Graham, Steven, Ou, Xuan   +4 more
core   +1 more source

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

Corticosterone alters materno-fetal glucose partitioning and insulin signalling in pregnant mice. [PDF]

, 2015
Glucocorticoids affect glucose metabolism in adults and fetuses, although their effects on materno-fetal glucose partitioning remain unknown. The present study measured maternal hepatic glucose handling and placental glucose transport together with ...
A. L. Fowden, A. N. Sferruzzi‐Perri, B. Musial, E. C. Jefferies, Ehrhardt RA, H. M. Fisher, Hay WW, J. S. Higgins, K. N. Dionelis, Molina RD, O. R. Vaughan   +10 more
core   +1 more source

Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia [PDF]

, 2017
Dysregulation of the mechanistic target of rapamycin complex 1 (mTORC1)-p70 ribosomal protein kinase 1 (S6K1) signaling pathway occurs frequently in acute myeloid leukemia (AML) patients.
Ghosh, Joydeep, Kapur, Reuben
core   +1 more source

Insulin resistance and exercise‐induced insulin sensitization in skeletal muscle: Insights from personalized phosphoproteomics

Journal of Diabetes Investigation, EarlyView.
Insulin resistance in muscle mainly disrupts non‐canonical insulin signaling pathways. Exercise‐induced MINDY1 S441 phosphorylation improves insulin sensitivity, highlighting its potential role in mediating exercise benefits in metabolic disease.
Shun Masuda, Takashi Matsuzaka
wiley   +1 more source

Inhibition of p70 S6 Kinase (S6K1) Activity by A77 1726 and Its Effect on Cell Proliferation and Cell Cycle Progress

Neoplasia: An International Journal for Oncology Research, 2014
Leflunomide is a novel immunomodulatory drug prescribed for treating rheumatoid arthritis. It inhibits the activity of protein tyrosine kinases and dihydroorotate dehydrogenase, a rate-limiting enzyme in the pyrimidine nucleotide synthesis pathway. Here,
Michelle E. Doscas, Ashley J. Williamson, Lydia Usha, Yedida Bogachkov, Geetha S. Rao, Fei Xiao, Yimin Wang, Carl Ruby, Howard Kaufman, Jingsong Zhou, James W. Williams, Yi Li, Xiulong Xu   +12 more
doaj   +1 more source

Muscle regeneration is improved by hot water immersion but unchanged by cold following a simulated musculoskeletal injury in humans

The Journal of Physiology, EarlyView.
Abstract figure legend Thirty‐four participants underwent muscle damage (electrically stimulated eccentric contractions) triggering regenerative processes following myofiber necrosis. Participants were treated for 10 days cold (CWI) (15 min, 12{degree sign}C), thermoneutral (TWI) (30 min, 32{degree sign}C) or hot (HWI) (60 min, 42{degree sign}C) water ...
Valentin Dablainville, Adèle Mornas, Tom Normand‐Gravier, Maha Al‐Mulla, Emmanouil Papakostas, Bruno Olory, Theodorakys Marin Fermin, Frantzeska Zampeli, Nelda Nader, Marine Alhammoud, Freya Bayne, Anthony M. J. Sanchez, Marco Cardinale, Robin Candau, Henri Bernardi, Sébastien Racinais   +15 more
wiley   +1 more source