Results 81 to 90 of about 20,664 (187)

Recessive nephrocerebellar syndrome on the Galloway-Mowat syndrome spectrum is caused by homozygous protein-truncating mutations of WDR73. [PDF]

, 2015
We describe a novel nephrocerebellar syndrome on the Galloway-Mowat syndrome spectrum among 30 children (ages 1.0 to 28 years) from diverse Amish demes.
Al Turki, S, Baple, E, Campellone, K, Chioza, BA, Crino, P, Crosby, A, Cross, H, Fogo, AB, Harding, B, Harlalka, GV, Heaps, AD, Hildebrandt, F, Hurles, ME, Jinks, RN, Koehler, AE, Maroofian, R, McGlincy, MH, Morton, DH, Morton, MC, Provencher, MM, Puffenberger, EG, Sadowski, CE, Smith, JD, Stempak, L, Strauss, KA, Tran, L, Wang, H, Wenger, O, Xin, B, Zaritsky, J   +29 more
core   +1 more source

Extinction of auditory threat memory triggers activation of p70 S6 kinase 1 in the basolateral nucleus of the amygdala [PDF]

Molecular Psychiatry, 2018
Extinction of auditory threat memory triggers activation of p70 S6 kinase 1 in the basolateral nucleus of the ...
T N Huynh, E Santini, E Mojica, A E Fink, B S Hall, R N Fetcho, L Grosenick, K Deisseroth, J E LeDoux, C Liston, E Klann   +10 more
openaire   +1 more source

Fully Tunable Phosphorylation of RPS6A Ensures the Successful Development of Arabidopsis Seedlings

Plant, Cell &Environment, EarlyView.
ABSTRACT Light enhances protein translation, enabling young seedlings to rapidly and timely acquire photosynthetic capacities. Sequential phosphorylation of ribosomal protein S6 (RPS6) was implicated in the light‐enhanced translation; however, the exact phosphorylation sites and the biological relevance of RPS6 multi‐phosphorylation in seedling ...
Yueh Cho, Guan‐Hong Chen, Shu‐Hsing Wu   +2 more
wiley   +1 more source

A preexisting rare PIK3CA e545k subpopulation confers clinical resistance to MEK plus CDK4/6 inhibition in NRAS melanoma and is dependent on S6K1 signaling [PDF]

, 2018
Combined MEK and CDK4/6 inhibition (MEKi + CDK4i) has shown promising clinical outcomes in patients with NRAS- mutant melanoma. Here, we interrogated longitudinal biopsies from a patient who initially responded to MEKi + CDK4i therapy but subsequently ...
Amaria, Rodabe N., Aplin, Andrew A., Carapeto, Fernando C.L., Chen, Merry, Chen, Pei-Ling, Davies, Michael A., Duose, Dzifa Y., Futreal, P. Andrew, Kwong, Lawrence N., Lazar, Alexander J., Li, Jun, Liang, Roger J., Liu, Mingguang, McQuade, Jennifer L., Roh, Whijae, Romano, Gabriele, Song, Ping, Teh, Jessica L.F., Wargo, Jennifer A., Zhang, David Y., Zhang, Jianhua   +20 more
core   +1 more source

Antenatal betamethasone impairs markers of cardiac development and function in near‐term lambs

Experimental Physiology, EarlyView.
Abstract figure Summary of key molecular differences in the left ventricle of near‐term lambs exposed to antenatal betamethasone, compared to saline. Pregnant ewes received two doses of either saline (Saline) or betamethasone (Betamethasone, intramuscular, 11.4 mg) given 24 h apart, before delivery at 140 days of gestation (dG, term = 150 dG).
Reza Amanollahi, Ashley S. Meakin, Stacey L. Holman, Vicki L. Clifton, Kent L. Thornburg, Michael D. Wiese, Kathryn L. Gatford, Mitchell C. Lock, Janna L. Morrison   +8 more
wiley   +1 more source

Corticosterone alters materno-fetal glucose partitioning and insulin signalling in pregnant mice. [PDF]

, 2015
Glucocorticoids affect glucose metabolism in adults and fetuses, although their effects on materno-fetal glucose partitioning remain unknown. The present study measured maternal hepatic glucose handling and placental glucose transport together with ...
A. L. Fowden, A. N. Sferruzzi‐Perri, B. Musial, E. C. Jefferies, Ehrhardt RA, H. M. Fisher, Hay WW, J. S. Higgins, K. N. Dionelis, Molina RD, O. R. Vaughan   +10 more
core   +1 more source

Phosphatidylinositol 3-Kinase (PI-3K)/Akt but Not PI-3K/p70 S6 Kinase Signaling Mediates IGF-1-Promoted Lens Epithelial Cell Survival

Investigative Opthalmology & Visual Science, 2004
To investigate the ability of insulin-like growth factor (IGF)-1 to prevent apoptosis in lens epithelial cells and the involvement of phosphatidylinositol 3-kinase (PI-3K)/Akt and PI-3K/p70 S6 kinase (p70 S6K) signaling in the cell-survival process.Apoptosis in rabbit lens epithelial cell cultures was induced by staurosporine (10 ng/mL).
Gudiseva, Chandrasekher, Dasetty, Sailaja   +1 more
openaire   +2 more sources

ALDOA‐Mediated Metabolic Reprogramming is a Targetable Vulnerability for Ferroptosis Sensitization in Cancer

Advanced Science, Volume 13, Issue 6, 30 January 2026.
ALDOA‐depletion‐mediated glycolytic reprogramming promotes autophagy‐mediated degradation of MBOAT2, increasing the ratio of phospholipids containing pro‐ferroptotic polyunsaturated fatty acids over anti‐ferroptotic monounsaturated fatty acids, and thus sensitizing cancer cells to ferroptosis.
Pengqi Wang, Kezhang He, Bowen Wang, Wei Zhou, Ying Zhang, Tianhua Ma, Sheng Ding   +6 more
wiley   +1 more source

Short-term low-protein diet during pregnancy alters islet area and protein content of phosphatidylinositol 3-kinase pathway in rats

Anais da Academia Brasileira de Ciências, 2015
The phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways mediate β cell growth, proliferation, survival and death. We investigated whether protein restriction during pregnancy alters islet morphometry or the expression and ...
CRISTIANA S.B. SALVATIERRA, SÍLVIA R.L. REIS, ANA F.M. PESSOA, LETÍCIA M.I. DE SOUZA, LUIZ F. STOPPIGLIA, ROBERTO V. VELOSO, MARISE A.B. REIS, EVERARDO M. CARNEIRO, ANTONIO C. BOSCHERO, EDSON M. COLODEL, VANESSA C. ARANTES, MÁRCIA Q. LATORRACA   +11 more
doaj   +1 more source

Cocoa polyphenols suppress TNF-α-induced vascular endothelial growth factor expression by inhibiting phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase kinase-1 (MEK1) activities in mouse epidermal cells [PDF]

, 2017
Cocoa polyphenols have antioxidant and anti-inflammatory effects. TNF-α is a pro-inflammatory cytokine that has a vital role in the pathogenesis of inflammatory diseases such as cancer and psoriasis.
Jung, Sung Keun, Kang, Nam Joo, Kim, Jong-Eun, Lee, Chang Yong, Lee, Hyong Joo, Lee, Ki Won, Son, Joe Eun   +6 more
core