Results 231 to 240 of about 14,891 (243)
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ProBDNF-p75NTR signaling in sterile inflammation
PhysiologyTrauma, injury, and surgical procedures cause tissue damage, sterile inflammatory responses, and significant immune system stress leading to immune dysregulation and increased susceptibility to secondary infections. The spleen is a reservoir of myeloid immune cells that are involved in inflammation following various tissue injuries.
Katherine Aby, Ryan Antony, Yifan Li
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Heparanase Expression and TrkC/p75NTR Ratios in Human Medulloblastoma
Clinical & Experimental Metastasis, 2006Medulloblastoma (MB), the most devastating and common brain tumor in children, is highly invasive and extremely difficult to treat. Identifying the properties of MB tumors that cause them to invade and metastasize is therefore imperative for the development of novel treatments.
Neeta D, Sinnappah-Kang +3 more
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p75NTR and apoptosis: Trk-dependent and Trk-independent effects
Trends in Neurosciences, 1997The ongoing dissection of the roles of p75NTR and TrkA, -B and -C in neurotrophin signaling has generated a number of apparent paradoxes. Limiting consideration to the role of p75NTR in cell death, a theory is proposed that is based on the following postulates: (1) that p75NTR displays a pro-apoptotic intrinsic (ligand-independent, Trk-independent ...
D E, Bredesen, S, Rabizadeh
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Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex
Nature, 2008Neurotrophins (NTs) are important regulators for the survival, differentiation and maintenance of different peripheral and central neurons. NTs bind to two distinct classes of glycosylated receptor: the p75 neurotrophin receptor (p75(NTR)) and tyrosine kinase receptors (Trks). Whereas p75(NTR) binds to all NTs, the Trk subtypes are specific for each NT.
Yong, Gong +3 more
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Regulation and function of P75NTR
2012The p75 neurotrophin receptor (p75NTR) has been known to play multiple roles in cell survival and apoptosis (Friedman, 2000; Maggirwar et al., 1998; Rabizadeh et al., 1993), axonal growth (Bentley and Lee, 2000), and cell differentiation (Hosomi et al., 2003).
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Signaling of neuronal cell death by the p75NTR neurotrophin receptor
Molecular Neurobiology, 1999The neurotrophin receptor (p75NTR) is best known for mediating tropic support by participating in the formation of high-affinity nerve growth factor (NGF) receptor complexes with trkA, however, p75NTR more recently has been shown to act as a bona fide death-signaling receptor, which can signal independently of trkA.
Coulson, E. J. +2 more
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Primary olfactory axons form ectopic glomeruli in mice lacking p75NTR
The Journal of Comparative Neurology, 2000The restricted expression of the low affinity nerve growth factor receptor p75NTR by olfactory ensheathing cells suggests that this molecule is involved in the development of the olfactory nerve pathway. To begin to understand the role of p75NTR, we examined the development of the primary olfactory system in p75NTR(-/-) and wild-type mice.
Tisay, KT, Bartlett, PF, Key, B
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Deletion of p75NTR impairs regeneration of peripheral nerves in mice
Life Sciences, 2009After peripheral nerve injury, p75NTR was upregulated in Schwann cells of the Wallerian degenerative nerves and in motor neurons but down-regulated in the injured sensory neurons. As p75NTR in neurons mediates signals of both neurotrophins and inhibitory factors, it is regarded as a therapeutic target for the treatment of neurodegeneration.
Zhang, Feng-He +4 more
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Untersuchungen über die funktionelle Rolle des Neurotrophinrezeptors p75NTR
2002Neurotrophine sind für die Entwicklung und Funktion des Nervensystems von Wirbeltieren unabdingbar. Sie entfalten ihre vielfältigen Funktionen über zwei Typen von Transmembranrezeptoren. Einerseits binden sie an die Trk-Rezeptoren, andererseits an den Neurotrophinrezeptor p75NTR.
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ProNGF BINDING TO p75NTR ACTIVATES PRO-INFLAMMATORY PATHWAYS
2017We recently demonstrated in patients with Juvenile Idiopathic Arthritis (JIA) that a reduced expression of TrkA, the NGF specific receptor, results in decreased anti-inflammatory responses. In this study, we focused on p75NTR and its specific ligand proNGF, the immature form of NGF, to assess their involvement in inflammatory responses.
G Minnone +6 more
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