Results 101 to 110 of about 1,463,960 (261)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A Certain Class of Equi-Statistical Convergence Based on $(p, q)$-integers via Deferred Nörlund Mean and Related Approximation Theorems

Analysis in Theory and Applications
Summary: The concept of equi-statistical convergence is more general than that of the well-established statistical uniform convergence. In this paper, we have introduced the idea of equi-statistical convergence, statistical point-wise convergence and statistical uniform convergence under the difference operator including \((p, q)\)-integers via ...
Das, A. A., Mishra, Vishnu Narayan, Paikray, S. K., Parida, P.   +3 more
openaire   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Approximation by modified ( p , q ) $(p,q)$ -gamma-type operators

Journal of Inequalities and Applications
The main object of this paper is to construct a new class of modified ( p , q ) $(p,q)$ -Gamma-type operators. For this new class of operators, in section one, the general moments are find; in section two, the Korovkin-type theorem and some direct ...
Naim Latif Braha
doaj   +1 more source

Construções concessivas, escalaridade e intersubjetividade: análise contrastiva de [ainda que p, q] e [mesmo que p, q]

Revista Linguística
Sob a perspectiva teórica da Linguística Cognitiva, este trabalho contrasta as construções concessivas [AINDA QUE P, Q] e [MESMO QUE P, Q] do português brasileiro em textos jornalísticos escritos.
Gabriela Silva Ribeiro, Lilian Vieira Ferrari   +1 more
doaj   +1 more source

Some Approximation Properties of Two Dimensional Chlodovsky-Bernstein Operators Based on (P, Q) Integer

In the present study, we introduce the two dimensional Chlodovsky type Bernstein operators based on (p,q)−integer. We examine approximation properties of our new operator by the help of Korovkin-type theorem. Further, we present the local approximation properties and establish the rates of convergence by means of the modulus of continuity and the ...
Ümit Karabıyık, Ali Karaisa, Adem Ayık   +2 more
openaire   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Competing anisotropic and Finsler ( p , q ) $(p,q)$ -Laplacian problems

Boundary Value Problems
The aim of this paper is to prove the existence of generalized variational solutions for nonlinear Dirichlet problems driven by anisotropic and Finsler Laplacian competing operators.
Dumitru Motreanu, Abdolrahman Razani
doaj   +1 more source