Results 81 to 90 of about 1,515,704 (240)

Tác động của việc giảm nợ đối với các nước nghèo qua sáng kiến HIPC

open access: yesTạp chí Khoa học Đại học Cần Thơ, 2016
Tính bền vững của các khoản nợ dài hạn đã là một mối quan tâm chính cho cả quốc gia mắc nợ và những người tài trợ cho các khoản nợ của họ. Trong cuối những năm 1990 các tổ chức Bretton Woods (Quỹ Tiền tệ Quốc tế và Ngân hàng Thế giới) đưa ra các sáng ...
Lê Thị Lanh, Lâm Ngọc Thiên Lý
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

A basic problem of ( p , q ) $(p,q)$ -Bernstein-type operators

open access: yesJournal of Inequalities and Applications, 2017
In this note, we give an elaboration of a basic problem on convergence theorem of ( p , q ) $(p, q)$ -analogue of Bernstein-type operators. By some classical analysis techniques, we derive an exact class of ( p n , q n ) $(p_{n},q_{n})$ -integer ...
Qing-Bo Cai, Xiao-Wei Xu
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

On Lyapunov-type inequalities for ( p , q ) $(p,q)$ -Laplacian systems

open access: yesJournal of Inequalities and Applications, 2017
We establish Lyapunov-type inequalities for a system involving one-dimensional ( p i , q i ) $(p_{i},q_{i})$ -Laplacian operators ( i = 1 , 2 $i=1,2$ ).
Mohamed Jleli, Bessem Samet
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

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