Results 81 to 90 of about 1,613,204 (240)
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Tác động của việc giảm nợ đối với các nước nghèo qua sáng kiến HIPC
Tạp chí Khoa học Đại học Cần Thơ, 2016 Tính bền vững của các khoản nợ dài hạn đã là một mối quan tâm chính cho cả quốc gia mắc nợ và những người tài trợ cho các khoản nợ của họ. Trong cuối những năm 1990 các tổ chức Bretton Woods (Quỹ Tiền tệ Quốc tế và Ngân hàng Thế giới) đưa ra các sáng ...
Lê Thị Lanh, Lâm Ngọc Thiên Lý
doaj +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
A basic problem of ( p , q ) $(p,q)$ -Bernstein-type operators
Journal of Inequalities and Applications, 2017 In this note, we give an elaboration of a basic problem on convergence theorem of ( p , q ) $(p, q)$ -analogue of Bernstein-type operators. By some classical analysis techniques, we derive an exact class of ( p n , q n ) $(p_{n},q_{n})$ -integer ...
Qing-Bo Cai, Xiao-Wei Xu
doaj +1 more source
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
FEBS Open Bio, EarlyView.Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source
On Lyapunov-type inequalities for ( p , q ) $(p,q)$ -Laplacian systems
Journal of Inequalities and Applications, 2017 We establish Lyapunov-type inequalities for a system involving one-dimensional ( p i , q i ) $(p_{i},q_{i})$ -Laplacian operators ( i = 1 , 2 $i=1,2$ ).
Mohamed Jleli, Bessem Samet
doaj +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1
FEBS Open Bio, EarlyView.The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn +2 more
wiley +1 more source