Results 71 to 80 of about 1,613,204 (240)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Some approximation properties of ( p , q ) $(p,q)$ -Bernstein operators

Journal of Inequalities and Applications, 2016
This paper is concerned with the ( p , q ) $(p,q)$ -analog of Bernstein operators. It is proved that, when the function is convex, the ( p , q ) $(p,q)$ -Bernstein operators are monotonic decreasing, as in the classical case.
Shin Min Kang, Arif Rafiq, Ana-Maria Acu, Faisal Ali, Young Chel Kwun   +4 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

The convergence of (p,q) $(p,q)$-Bernstein operators for the Cauchy kernel with a pole via divided difference

Journal of Inequalities and Applications, 2019
In this paper, some qualitative approximation results for the (p,q) $(p,q)$-Bernstein operators Bp,qn(f;x) $B_{p,q}^{n}(f;x)$ are obtained for the Cauchy kernel 1x−α $\frac{1}{x-\alpha }$ with a pole α∈[0,1] $\alpha \in {}[ 0,1]$ for q>p>1 $q>p>1$.
Faisal Khan, Mohd Saif, Aiman Mukheimer, M. Mursaleen   +3 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Multiplicative Valency-Based Descriptors for Silicon Carbides Si2C3 − I[p, q], Si2C3 − II[p, q], Si2C3 − III[p, q], and SiC3 − III[p, q] in Drug Applications

Journal of Chemistry, 2020
Topological indices help us to collect information about algebraic graphs and give us a mathematical approach to understand the properties of algebraic structures.
Jin Xu, Nasir Javaid, Shamas Bilal, Muhammad Rafaqat, Iskander Tlili   +4 more
doaj   +1 more source

On weighted statistical convergence based on (p,q)-integers and related approximation theorems for functions of two variables

Journal of Mathematical Analysis and Applications, 2016
Let ...
openaire   +2 more sources