Results 71 to 80 of about 26,473,484 (282)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Some trapezoid and midpoint type inequalities via fractional ( p , q ) $(p,q)$ -calculus

Advances in Difference Equations, 2021
Fractional calculus is the field of mathematical analysis that investigates and applies integrals and derivatives of arbitrary order. Fractional q-calculus has been investigated and applied in a variety of research subjects including the fractional q ...
Pheak Neang, Kamsing Nonlaopon, Jessada Tariboon, Sotiris K. Ntouyas, Praveen Agarwal   +4 more
doaj   +1 more source

Some approximation results by Bernstein-Kantorovich operators based on (p,q)-integers

, 2015
In this paper, First we have given the modified form of (p,q)-analogues of Bernstein and Bernstein operators [21-23] and then we introduce a new analogue of Bernstein-Kantorovich operators which we call as (p,q)-Bernstein-Kantorovich operators. We discuss approximation properties for these operators based on Korovkin's type approximation theorem and we
Mursaleen, M., Ansari, Khursheed J., Khan, Asif   +2 more
openaire   +2 more sources

Recent results on (p,q)-Laplacian type equations [PDF]

, 2017
Start ing from a new sum decomposit ion of W1,p(RN ) ∩W1,q(RN ) and using a variat ional approach, we invest igate the existence of mult ipleweak solut ions of a (p, q)–Laplacian equat ion on RN , for 1 < q < p < N , with a sign–changing potent ial ...
Bartolo, Rossella
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Maximal abelian subalgebras of e(p, q) algebras [PDF]

, 1999
Maximal abclian subalgebras (MASAs) of one of the classical real inhomogencous Lie algebras are constructed, namely those of the pseudoeuclidean Lie algebra e(p, q).
Thomova, Z., Z. Thomova, P. Winternitz, Winternitz, P.   +3 more
core   +1 more source

On post-quantum multiparameter Riemann–Liouville fractional integral inequalities with application

Journal of Inequalities and Applications
Post-quantum integral inequalities involving the Riemann–Liouville fractional integral have a significant role in understanding and modeling systems with nonlocal interactions; anomalous diffusion and memory effects make them indispensable for addressing
Sobia Rafeeq, Sabir Hussain, Drakhshan Mansab, Hijaz Ahmad, Taha Radwan   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Approximation Properties of Chlodovsky-Type Two-Dimensional Bernstein Operators Based on (p, q)-Integers

Symmetry
In the present study, we introduce the two-dimensional Chlodovsky-type Bernstein operators based on the (p,q)-integer. By leveraging the inherent symmetry properties of (p,q)-integers, we examine the approximation properties of our new operator with the help of a Korovkin-type theorem.
Ümit Karabiyik, Adem Ayik, Ali Karaisa
openaire   +1 more source