Results 61 to 70 of about 1,613,204 (240)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Some inequalities for (p,q) $(p,q)$-mixed volume
Journal of Inequalities and Applications, 2018 Lutwak, Yang, and Zhang introduced the concept of (p,q) $(p,q)$-mixed volume whose special cases contain the Lp $L_{p}$-mixed volume and the Lp $L_{p}$-dual mixed volume.
Bin Chen, Weidong Wang
doaj +1 more source
SymmetryIn the present study, we introduce the two-dimensional Chlodovsky-type Bernstein operators based on the (p,q)-integer. By leveraging the inherent symmetry properties of (p,q)-integers, we examine the approximation properties of our new operator with the help of a Korovkin-type theorem.
Ümit Karabiyik, Adem Ayik, Ali Karaisa
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Conformal (p, q) supergeometries in two dimensions
Journal of High Energy Physics, 2023 We propose a superspace formulation for conformal (p, q) supergravity in two dimensions as a gauge theory of the superconformal group OSp0(p|2; ℝ) × OSp0(q|2; ℝ) with a flat connection.
Sergei M. Kuzenko +1 more
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Some approximation results on Bernstein-Schurer operators defined by (p,q)-integers (Revised)
, 2015 In the present article, we have given a corrigendum to our paper "Some approximation results on Bernstein-Schurer operators defined by (p,q)-integers" published in Journal of In- equalities and Applications (2015) 2015:249.
Mursaleen, M. +2 more
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Filomat, 2019 The preliminary idea of statistical weighted B-summability was introduced by Kadak et al. [27]. Subsequently, deferred weighted statistical B-summability has recently been studied by Pradhan et al. [38]. In this paper, we study statistical versions of deferred weighted B-summability as well as deferred weighted B-convergence with respect to
Zraiqat, Amjed +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source