Results 61 to 70 of about 1,481,183 (261)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Conformal (p, q) supergeometries in two dimensions

Journal of High Energy Physics, 2023
We propose a superspace formulation for conformal (p, q) supergravity in two dimensions as a gauge theory of the superconformal group OSp0(p|2; ℝ) × OSp0(q|2; ℝ) with a flat connection.
Sergei M. Kuzenko, Emmanouil S. N. Raptakis   +1 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A certain class of deferred weighted statistical B-summability involving (p,q)-integers and analogous approximation theorems

Filomat, 2019
The preliminary idea of statistical weighted B-summability was introduced by Kadak et al. [27]. Subsequently, deferred weighted statistical B-summability has recently been studied by Pradhan et al. [38]. In this paper, we study statistical versions of deferred weighted B-summability as well as deferred weighted B-convergence with respect to
Zraiqat, Amjed, Paikray, S. K., Dutta, Hemen   +2 more
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Some approximation results on Bernstein-Schurer operators defined by (p,q)-integers (Revised)

, 2015
In the present article, we have given a corrigendum to our paper "Some approximation results on Bernstein-Schurer operators defined by (p,q)-integers" published in Journal of In- equalities and Applications (2015) 2015:249.
Mursaleen, M., Nasiruzzaman, Md., Nurgali, Ashirbayev   +2 more
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Some approximation properties of ( p , q ) $(p,q)$ -Bernstein operators

Journal of Inequalities and Applications, 2016
This paper is concerned with the ( p , q ) $(p,q)$ -analog of Bernstein operators. It is proved that, when the function is convex, the ( p , q ) $(p,q)$ -Bernstein operators are monotonic decreasing, as in the classical case.
Shin Min Kang, Arif Rafiq, Ana-Maria Acu, Faisal Ali, Young Chel Kwun   +4 more
doaj   +1 more source

Approximation Properties of Chlodovsky-Type Two-Dimensional Bernstein Operators Based on (p, q)-Integers

Symmetry
In the present study, we introduce the two-dimensional Chlodovsky-type Bernstein operators based on the (p,q)-integer. By leveraging the inherent symmetry properties of (p,q)-integers, we examine the approximation properties of our new operator with the help of a Korovkin-type theorem.
Ümit Karabıyık, Ali Karaisa, Adem Ayık   +2 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source