Results 91 to 100 of about 24,223,577 (290)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source

Carbapenem-resistant hypervirulent P. aeruginosa coexpressing exoS/exoU in Brazil

Journal of Global Antimicrobial Resistance
Background: Pseudomonas aeruginosa is a ubiquitous organism with high clinical impact due to its intrinsic resistance to many antimicrobial drugs and ability to acquire antibiotic resistance and virulence genes.
Sergio M. Morgado, Nathália M.S. Bighi, Fernanda S. Freitas, Caio Rodrigues, Érica L. Fonseca, Ana Carolina Vicente   +5 more
doaj   +1 more source

Structure–Function Relationship of Aminopeptidase P from Pseudomonas aeruginosa

Frontiers in Microbiology, 2017
PepP is a virulence-associated gene in Pseudomonas aeruginosa, making it an attractive target for anti-P. aeruginosa drug development. The encoded protein, aminopeptidases P (Pa-PepP), is a type of X-prolyl peptidase that possesses diverse biological ...
Cui-Ting Peng, Cui-Ting Peng, Li Liu, Li Liu, Chang-Cheng Li, Li-Hui He, Tao Li, Ya-Lin Shen, Chao Gao, Ning-Yu Wang, Ning-Yu Wang, Yong Xia, Yi-Bo Zhu, Ying-Jie Song, Qian Lei, Luo-Ting Yu, Luo-Ting Yu, Rui Bao   +17 more
doaj   +1 more source

Phagetherapies for infections caused by P. aeruginosa

, 2013
The hospital infections can be prevented by controlling some factors related with staff, material, and environment. At this moment the existing legislation regulates procedures that prevent the propagation of the infection and/or of the agents that ...
Prudêncio, Cristina, Baylina, Pilar, Fernandes, Rúben, Reis, Ana, Ferraz, Ricardo, BAYLINA MACHADO, PILAR   +5 more
core   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source

Pseudomonas aeruginosa biofilm formers in drinking water

, 2023
Currently there has been an increase in demand for bottled water, this is due to the population’s dissatisfaction with the quality of water provided by public agencies. The present study sought to evaluate the presence of biofilm-forming P. aeruginosa in
Luzia Angélica Alves Cavalcante
core  

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

Advanced Science, EarlyView.
Catheter‐related bloodstream infections (CRBSI) caused by drug‐resistant Gram‐negative bacteria remain a major clinical challenge. Here, a polydopamine‐assisted depolymerase coating degrades bacterial capsules and restores serum‐mediated killing, effectively suppressing biofilms and reducing bacterial burden in vitro, ex vivo, and in vivo, presenting a
Lingkai Dong, Xingjin Li, Tao Hu, Qianqian Lu, Xiaoxu Zhang, Xi Chen, Yifan Luo, Zhong Zuo, Ronald Man Yeung Wong, Miao Xu, Tiancong Zhao, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Analysis of susceptibility profile of Pseudomonas spp. and prevalence of bacterial samples from the surfaces of dental consulting-rooms

Revista de Ciências Farmacêuticas Básica e Aplicada, 2005
The aim of this research was to evaluate the susceptibility profile of Pseudomonas spp. and the prevalence of bacterial samples isolated from horizontal surfaces surrounding wash-basins used by dentists in several adjoined consulting-rooms, at points ...
R.C.L.R. Pietro, S. Kashima, A.M.F. Almeida, C.H.P.M. Silva, L.B. Rocha, J.M. Pádua, R.C.C. Lia   +6 more
doaj  

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source