Results 101 to 110 of about 24,653,664 (251)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Overview: Cycling Scotland was established in 2003 as a national charity to represent cycling interests and to increase levels of cycling. Our vision is of a sustainable, inclusive and healthy Scotland where anyone, anywhere, can enjoy all the ...
Cycling Scotland
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Reproducibility of a Laboratory Based 1-km Wattbike Cycling Time Trial in Competitive Cyclists
, 2014 The purpose of this study was to evaluate the reliability of a 1-km cycling time trial using a Wattbike cycling ergometer in competitive cyclists. Ten competitive male cyclists (mean ᠓D; 63.9 ᠵ.1 mL竧-1筩n-1) performed a VO2max test and a familiarization ...
Bellinger, Phil, Minahan, Clare
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Soil SystemsTo explore the effects of legume intercropping on soil nitrogen (N) and phosphorus (P) cycling processes in mulberry plantations during the winter fallow period, three treatments were set up: control (no intercropping, CK), single-legume intercropping ...
Guantao Chen +6 more
doaj +1 more source
Understanding urban cycling behaviours in space and time [PDF]
The aim of this research thesis was to understand how the urban built environment interacts with utility cycling behaviours in space and time. Using mixed methods entrenched in the philosophy of pragmatism, the research contributed to an as yet under ...
Yeboah, Godwin
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A matter of utility? Rationalising cycling, cycling rationalities
, 2015 This paper discusses how dominant policy paradigms promote a ‘utility’ model of transport, prioritising the destruction of distance and the minimisation of time spent travelling.
Aldred, R.
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source