Results 111 to 120 of about 24,653,664 (251)
, 2013 Revision June 2013-Aug. 2014.Other title Mobile, AL to Fulton, MS, 400.5 miles. Fulton, MS to Owensboro, KY, 435 miles. Owensboro, KY to Milford, OH, 373.5 miles. Milford, OH to Erie, PA, 418.5 miles. Erie, PA to Owen Sound, ON, 378 miles.
Adventure Cycling Association, cartographer;
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Momentum integration: the syntax of cycling [PDF]
, 2015 Cycling has long been known to have significant physical and mental health benefits for its participants. It has the potential to significantly reduce the carbon footprint of a city, increase personal mobility, improve transportation equality, improve ...
Dalton, Nicholas, Dalton, Nick
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Seasonal Changes in Pinus tabuliformis Root-Associated Fungal Microbiota Drive N and P Cycling in Terrestrial Ecosystem. [PDF]
Front Microbiol, 2020 Wang HH +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Ecotoxicology and Environmental SafetyErythromycin (EM) is widely detected in agroecosystems, yet its mechanistic impact on microbially driven soil phosphorus (P) cycling remains limited. Here, we integrated Hedley P fractionation with metagenomic sequencing in soil microcosms exposed to EM (
Zhe Wang +5 more
doaj +1 more source
The reliability of performance during computer-simulated varying gradient cycling time trials [PDF]
, 2014 Ergometer based time trials are commonly used to assess performance changes due to training or other interventions. This investigation establishes the reliability of a novel computer simulated cycling time trial.
Clark, Bradley +4 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source