Results 51 to 60 of about 24,653,664 (251)

Cycling on the Verge? Exploring the Place of Utility Cycling in Contemporary New Zealand Transport Policy [PDF]

open access: yes, 2014
Efforts to increase cycling as a mode of transport (utility cycling) occur at central, regional and local levels of government through a range of supportive strategies, research, and guidelines.
Smith, Megan
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Influence of drought stress on phosphorus dynamics and maize growth in tropical ecosystems

open access: yesBMC Plant Biology
Drought has a significant impact on ecosystem functions, especially on the biogeochemical cycling of phosphorus (P), which is a crucial nutrient for plant growth and productivity. Despite its importance, the effects of different drought scenarios on soil
Mohsin Mahmood   +10 more
doaj   +1 more source

Cycling and the city: a case study of how gendered, ethnic and class identities can shape healthy transport choices. [PDF]

open access: yes, 2011
As a form of 'active transport', cycling has been encouraged as a route to improving population health. However, in many high-income countries, despite being widely seen as a 'healthy' choice, few people do cycle for transport.
Green, Judith   +7 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Effects of a 2-km Swim on Markers of Cycling Performance in Elite Age-Group Triathletes

open access: yesSports, 2019
The purpose of this study was to examine the effects of a 2-km swim on markers of subsequent cycling performance in well-trained, age-group triathletes.
Jeffrey Rothschild, George H. Crocker
doaj   +1 more source

Quadriceps Muscle Fatigue Reduces Extension and Flexion Power During Maximal Cycling

open access: yesFrontiers in Sports and Active Living, 2022
Purpose: To investigate how quadriceps muscle fatigue affects power production over the extension and flexion phases and muscle activation during maximal cycling.Methods: Ten participants performed 10-s maximal cycling efforts without fatigue and after ...
Steven J. O'Bryan   +7 more
doaj   +1 more source

The level of mendione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion

open access: yes, 2012
Pancreatic β-cells release insulin in response to elevation of glucose from basal (4–7 mM) to stimulatory (8–16 mM) levels. Metabolism of glucose by the β-cell results in the production of low levels of reactive oxygen intermediates (ROI), such as ...
Womack, Trayce   +8 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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