The Dual Face of Fusobacterium nucleatum in Cancer: Foe, Friend or Both?
Journal of Periodontal Research, EarlyView.Fusobacterium nucleatum has established interactions with cancers in humans. However, contrary to a traditional view that these interactions are uniformly pro‐tumoural, recent evidence suggests a more nuanced role, where contact‐dependent and contact‐independent mechanisms may support either tumour progression or restriction depending on tumour site ...
Anjali Chander +3 more
wiley +1 more source
USP22 knockdown attenuates <i>P. gingivalis</i>-induced EndoMT and CNS inflammation: a link between periodontitis and neuroinflammation. [PDF]
Front NeurosciWang H, Wang M, Shen J, Zhang H, Duan C.
europepmc +1 more source
Journal of Periodontal Research, EarlyView.This systematic review evaluated drug‐target Mendelian randomisation studies on periodontitis. Twelve studies identified host‐response‐related targets mainly involved in inflammatory, complement, and immune pathways. Although some targets were linked to existing drugs, the evidence remains preliminary and heterogeneous, requiring replication and ...
Luigi Nibali +4 more
wiley +1 more source
CKIP-1 mediates P. gingivalis-suppressed osteogenic/cementogenic differentiation of periodontal ligament cells partially via p38 signaling pathway. [PDF]
J Oral Microbiol, 2023 Huang X +7 more
europepmc +1 more source
Metagenomic Evaluation of Oral Microbiota in Patients Affected by Oral Lichen Planus: A Pilot Study
Oral Diseases, EarlyView.ABSTRACT Objective To characterize the oral bacterial and fungal microbiota of symptomatic oral lichen planus patients undergoing topical corticosteroid therapy and to explore microbial patterns potentially associated with subsequent oral candidiasis. Methods Twelve patients with clinically and histologically confirmed OLP were enrolled.
A. Dormiente +5 more
wiley +1 more source
Bacterial-host interactions in periodontal prognosis: Role of <i>P. gingivalis</i> and IL-8. [PDF]
J Dent SciLin YC +4 more
europepmc +1 more source
Oral Phageome as Potential Modulators of Periodontal Dysbiosis. A Systematic Review
Oral Diseases, EarlyView.ABSTRACT Introduction The oral phageome, comprising bacteriophages inhabiting the oral cavity, has been proposed as a potential modulator of periodontal health and disease. This systematic review synthesizes current evidence on interactions between bacteriophages, key periodontal bacteria, and the host in periodontitis.
Marco Bonilla +3 more
wiley +1 more source
Targeted Inhibition of P. gingivalis OMV-derived TsRNA by tetrahedral framework nucleic acids promotes periodontal regeneration. [PDF]
J NanobiotechnologyCao Y +11 more
europepmc +1 more source
P. gingivalis Infection Upregulates PD-L1 Expression on Dendritic Cells, Suppresses CD8+ T-cell Responses, and Aggravates Oral Cancer. [PDF]
Cancer Immunol Res, 2023 Ren J +6 more
europepmc +1 more source
Oral Diseases, EarlyView.ABSTRACT Objectives To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non‐erosive subtype (NEOLP) through transcriptomic analysis. Methods We analysed bulk RNA‐seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA ...
Kisung Sheen +5 more
wiley +1 more source