Results 121 to 130 of about 5,197,105 (317)

Domain-oriented topic discovery based on features extraction and topic clustering [PDF]

open access: yes, 2020
Topic detection technology can automatically discover new topics on the Internet. This paper investigates domain-oriented feature extraction methods, and proposes a keyword feature extraction method ITFIDF-LP, a subject word feature extraction method LDA-
Wang W., Lio P., Zhou X., Lu X., Hui P.
core   +1 more source

Serum Metabolic Fingerprints Characterize Systemic Lupus Erythematosus

open access: yesAdvanced Science
Metabolic fingerprints in serum characterize diverse diseases for diagnostics and biomarker discovery. The identification of systemic lupus erythematosus (SLE) by serum metabolic fingerprints (SMFs) will facilitate precision medicine in SLE in an early ...
Shunxiang Li   +11 more
doaj   +1 more source

Converting Immune Cold into Hot by Biosynthetic Functional Vesicles to Boost Systematic Antitumor Immunity

open access: yesiScience, 2020
Summary: Immune cold tumor characterized by low immunogenicity, insufficient and exhausted tumor-infiltrating lymphocytes, and immunosuppressive microenvironment is the main bottleneck responsible for low patient response rate of immune checkpoint ...
Ming Wu   +12 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Science with Simbol-X [PDF]

open access: yes, 2008
Simbol-X is a French-Italian mission, with a participation of German laboratories, for X-ray astronomy in the wide 0.5-80 keV band. Taking advantage of emerging technology in mirror manufacturing and spacecraft formation flying, Simbol-X will push ...
Ferrando P.   +22 more
core  

Evidence for the decay X(3872)→ψ(2S)γ [PDF]

open access: yes, 2014
Evidence for the decay mode X(3872)→ψ(2S)γ in B+→X(3872)K+ decays is found with a significance of 4.4 standard deviations. The analysis is based on a data sample of proton–proton collisions, corresponding to an integrated luminosity of 3 fb−1, collected ...
Hennessy K.   +999 more
core   +1 more source

Observation of X(2370) and search for X(2120) in J/ ψ→ γKK ̄ η′ [PDF]

open access: yes, 2020
Using a sample of 1.31×109J/ψ events collected with the BESIII detector, we perform a study of J/ ψ→ γKK ̄ η′. X(2370) is observed in the KK ̄ η′ invariant-mass distribution with a statistical significance of 8.3 σ.
Morales C. M.   +464 more
core   +1 more source

Steklov problems involving the \(p(x)\)-Laplacian

open access: yesElectronic Journal of Differential Equations, 2014
In this article, the authors study the problem \[ \Delta_{p(x)}u=a(x)|u|^{p(x)-2}u\text{, }x\in\Omega \] subject to the boundary condition \[ |\nabla u|^{p(x)-2}\frac{\partial u}{\partial\nu}=\lambda f(x,u)\text{, }x\in\partial\Omega. \] Here the set \(\Omega\subseteq\mathbb{R}^{N}\) is bounded with a smooth boundary, \(\lambda>0\) is a parameter, and \
Ghasem A. Afrouzi   +2 more
openaire   +2 more sources

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

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