Results 51 to 60 of about 784,503 (252)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Green Processing and Synthesis, 2023 In response to the challenge of high packet loss rates due to poor mobility of PCs, we introduce a sustainable design evaluation system centered around wireless network handheld terminals.
Zhang Lin, Qin Zhen
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Quality of Service (QoS) improving schemes in optical networks
Heliyon, 2020 In optical networks, such as OPS/OBS, the network results into significant loss in the network layer. When the loss significantly deteriorates the QoS by increasing the Bit Error Rate (BER), a viable approach can be used to increase the performance. This
Dawit Hadush Hailu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Unequal loss protection scheme using a quality prediction model in a Wi-Fi broadcasting system
International Journal of Distributed Sensor Networks, 2019 Wireless local area network–based broadcasting techniques are a type of mobile Internet Protocol television technology that simultaneously transmits multimedia content to local users.
Dong Hyun Kim, Jong Deok Kim
doaj +1 more source
Block Recovery Rate-Based Unequal Error Protection for Three-Screen TV
Applied Sciences, 2017 This paper describes a three-screen television system using a block recovery rate (BRR)-based unequal error protection (UEP). The proposed in-home wireless network uses scalable video coding (SVC) and UEP with forward error correction (FEC) for ...
Hojin Ha, Eun-Seok Ryu
doaj +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source