Results 51 to 60 of about 179,193 (249)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The benefits of coloring pages for Varityskuvat
, 2022 Coloring makes adults feel like a child again and takes them back to the happiest and most carefree period of their lives. Remembering some of these moments helps us relax and be more optimistic about the future.
Jones Andrew
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Worst-case analysis for new online bin packing problems [PDF]
, 2013 We consider two new online bin packing problems, the online Variable Cost and Size Bin Packing Problem (o-VCSBPP) and the online Generalized Bin Packing Problem (o-GBPP).
Baldi, Mauro Maria +3 more
core
Coloring count cones of planar graphs [PDF]
, 2022 For a plane near‐triangulation G with the outer face bounded by a cycle C, let nG⋆ denote the function that to each 4‐coloring ψ of C assigns the number of ways ψ extends to a 4‐coloring of G.
Lidicky, Bernard, Dvořák, Zdeněk
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
On The Packing k-Coloring of Edge Corona Product
, 2019 All graph in this paper is connected and simple graph. Let du,v be a distance between any vertex u and v in graph G V,E . A function c :VG1, 2,, k is called a packing k-coloring if every two vertices of color i are at least distance i 1. G
KRISTIANA, Arika Indah +3 more
core
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source