Results 61 to 70 of about 4,092 (253)
Benefits of a population: five mechanisms that advantage population-based algorithms [PDF]
, 2010 This paper identifies five distinct mechanisms by which a population-based algorithm might have an advantage over a solo-search algorithm in classical optimization. These mechanisms are illustrated through a number of toy problems.
Prugel-Bennett, A.
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Dagstuhl Reports : Volume 1, Issue 2, February 2011
, 2011 Online Privacy: Towards Informational Self-Determination on the Internet (Dagstuhl Perspectives Workshop 11061) : Simone Fischer-Hübner, Chris Hoofnagle, Kai Rannenberg, Michael Waidner, Ioannis Krontiris and Michael Marhöfer Self-Repairing Programs ...
Schloss Dagstuhl, Leibniz-Zentrum für Informatik
core
In this paper, we introduce a new concept in graph coloring, namely the \textit{packing total coloring}, which extends the idea of packing coloring to both the vertices and the edges of a given graph. More precisely, for a graph $G$, a packing total coloring is a mapping $c: V(G) \cup E(G) \rightarrow \{1, 2, \ldots\}$ with the property that for any ...
Ferme, Jasmina, Štesl, Daša Mesarič
openaire +2 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
, 2010 泛寬著色問題主要來自無線網路的頻道分配、資源配置及生物多樣性模型。舉例來說，為了避免互相干擾，美國聯邦通訊委員會規定廣播電台必須相隔足夠距離才能使用相同的頻率，因為物理的限制，不同頻率需要不同的距離，政府部門必須適當配置才能使整個廣播網絡順利運作。此問題化約成圖論型式：對於給定的有限遞增正整數數列$(s_1,s_2,dots,s_k)$及圖$G$，若我們能夠給予圖上的每個頂點一個顏色，使得著第$i$色的兩個相異頂點距離超過$s_i$，則稱此圖可被$(s_1,s_2,dots,s_k)$著色 ...
Chen, Sheng-Hua, 陳聖華
core
Quantum Algorithms for Graph Coloring and other Partitioning, Covering, and Packing Problems
, 2023 Let U be a universe on n elements, let k be a positive integer, and let F be a family of (implicitly defined) subsets of U. We consider the problems of partitioning U into k sets from F, covering U with k sets from F, and packing k non-intersecting sets ...
Gaspers, Serge, Li, Jerry Zirui
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source