Results 61 to 70 of about 255,219 (274)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
, 2009 Given a planar point set and an integer $k$, we wish to color the points with $k$ colors so that any axis-aligned strip containing enough points contains all colors. The goal is to bound the necessary size of such a strip, as a function of $k$.
Aloupis, G. +8 more
core +3 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Two-colorings with many monochromatic cliques in both colors [PDF]
, 2013 Color the edges of the n-vertex complete graph in red and blue, and suppose that red k-cliques are fewer than blue k-cliques. We show that the number of red k-cliques is always less than cknk, where ck∈(0, 1) is the unique root of the equation zk=(1-z)k ...
Frankl, Péter +3 more
core +1 more source
Packing problems in edge-colored graphs
Discrete Applied Mathematics, 1994 Let \(F\) be a graph edge-colored with \(k\) colors. A partition (family of disjoint subsets, respectively) \(\{V_ 1,\dots,V_ m\}\) of the vertex set of a complete graph edge-colored with \(k\) colors is an \(F\)-partition (\(F\)-packing, respectively) if each \(V_ i\) contains a spanning copy of \(F\) (with the same color pattern as \(F\)).
Hell, P., Manoussakis, Y., Tuza, Zs.
openaire +2 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Algorithms to Approximate Column-Sparse Packing Problems
, 2019 Column-sparse packing problems arise in several contexts in both deterministic and stochastic discrete optimization. We present two unifying ideas, (non-uniform) attenuation and multiple-chance algorithms, to obtain improved approximation algorithms for ...
Brubach, Brian +3 more
core +1 more source
Implications of ideas on super-hydrophobicity for water repellent soil [PDF]
, 2007 Water repellence is an important factor in soil erosion due to its role in inhibiting the re-establishment of vegetation after fire and due to its enhancement of run-off.
Adamson +31 more
core +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source