Results 111 to 120 of about 116,760 (305)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Effect of spinning variables on packing density of cotton yarn

, 2015
In this study, fibre distribution through the cross-sections of ring-spun yarns and their packing density values has been investigated to provide a better understanding of the internal structures of ring-spun yarns manufactured by changing different ...
Shafqat, A R; national textile university, faisalabad, pakistan, Muzaffar, M ; national textile university, faisalabad, pakistan, Iqbal, M ; national textile university, faisalabad, pakistan, Ahmed, F ; national textile university, faisalabad, pakistan, Hussain, T ; national textile university, faisalabad, pakistan, Zahra, N ; national textile university, faisalabad, pakistan, Sarwar, A ; national textile university, faisalabad, pakistan, Hussain, U ; national textile university, fiasalabad, Pakistan   +7 more
core   +1 more source

Dense Pure Tungsten Fabricated by Selective Laser Melting

Applied Sciences, 2017
Additive manufacturing using tungsten, a brittle material, is difficult because of its high melting point, thermal conductivity, and oxidation tendency.
Dianzheng Wang, Chenfan Yu, Xin Zhou, Jing Ma, Wei Liu, Zhijian Shen   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effect of the structured packing height on efficiency of freons mixture separation in a large-scale model of distillation column

MATEC Web of Conferences, 2017
Results of experimental studies of heat-and-mass transfer and hydrodynamic processes at distillation on a regular packing are presented. The mixture of freons R114–R21 at the pressure of 0.3 MPa was used as a working mixture. The mixture was separated on
Pavlenko Aleksandr, Zhukov Vladimir, Pecherkin Nikolay, Nazarov Aleksandr, Li Xingang, Liu Mingyan, Sui Hong, Li Hong   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

On the perfect hexagonal packing of rods

, 2006
In most cases the hexagonal packing of fibrous structures or rods extremizes the energy of interaction between strands. If the strands are not straight, then it is still possible to form a perfect hexatic bundle.
Starostin, EL
core  

Density of the p3 packing of ellipses

, 1995
It is shown that the density of the p3 packing of ellipses never exceeds the maximum density ϱ = π/[unk] through numerical computations and series expansions. This maximum density is attained only by the closest packing of circles, p6mm.

core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Results in Sphere Packing Density

, 2007
In recent years there has been significant work done in the field of sphere packing. In this paper, we present an overview of some classic results as motivation for a series of theorems that give general density conditions on classes of packings ...
Kusner, Woden
core