Results 141 to 150 of about 116,760 (305)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Packing density of inkjet printed paths

, 2018
Purpose This paper aims to study the packing density of printed paths on different substrate materials. It presents problems which appear when the necessity of printing one or more narrow paths occurs.
Tadeusz Wałach, Grzegorz Tomaszewski, Jerzy Potencki   +2 more
core   +1 more source

Diverse mangroves deviate from other angiosperms in their genome size, leaf cell size and cell packing density relationships. [PDF]

Ann Bot, 2023
Jiang GF, Li SY, Dinnage R, Cao KF, Simonin KA, Roddy AB.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Atomic volume, packing density and valence of Cesium under pressure

, 2006
The volume changes of cesium under pressure are discussed with respect to the packing density of the atoms and valence. The element is univalent in densely packed Cs I and Cs II.
Trömel, Martin, Hübner, Sven, Taxer, Karlheinz   +2 more
core   +1 more source

Experimental Study on the Thermal Performance of a Counterflow Wet Cooling Tower with Bamboo Woven Packing

BioResources
Bamboo packing has been found to be a superior alternative to plastic packing for cooling towers, but traditional bamboo grid packing comprises numerous components, resulting in high production costs and low production efficiency.
Lisheng Chen, Jiawei Kang, Meiling Chen, Caiping Lian, Jiping Lu, Tengfei Wang, Xiaohui Yang, Xinxin Ma   +7 more
doaj  

The Effects of Dolomite Powder Content and Type on the Yield Stress Relationship between Self-Compacting Mortar and Paste

Buildings
Self-compacting concrete (SCC), known for its excellent fluidity and self-compacting ability, is widely used in civil engineering. To enhance the comprehensive performance of SCC, dolomite powder (DP) is integrated as a substitute for cement.
Jingbin Zhang, Hongyu Chen, Yan Jia, Pingcuo Zhuoma, Miao Lv   +4 more
doaj   +1 more source

Exceptional Packing Density of Ammonia in a Dual-Functionalized Metal-Organic Framework. [PDF]

J Am Chem Soc, 2021
Marsh C, Han X, Li J, Lu Z, Argent SP, da Silva I, Cheng Y, Daemen LL, Ramirez-Cuesta AJ, Thompson SP, Blake AJ, Yang S, Schröder M.   +12 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Sustainability-driven model for predicting compressive strength in concrete structures

Cogent Engineering
Over the past few decades, enhancing the sustainability of concrete structures has become a worldwide necessity. This study proposes a mathematical model for predicting compressive strength (CS), aiming to further the objective of designing sustainable ...
Fayez Moutassem, Mohamad Kharseh
doaj   +1 more source