Results 71 to 80 of about 144,663 (264)
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
A φ-Contractivity and Associated Fractal Dimensions
Fractal and FractionalIn this paper, we extend the concept of dimension of sets to some general frameworks relative to a gauge function φ, where two simultaneous dimensions are introduced.
Nifeen H. Altaweel +2 more
doaj +1 more source
Use of genetic algorithms for solving problems of optimal cutting
ITM Web of Conferences, 2016 Cutting and packing problem is one of the most common optimization problem. Even a small space or material savings allow obtaining substantial advantages on an industrial scale. This paper proposes the genetic algorithm to solve this problem. It includes
Sergievskiy Maxim, Syroezhkin Sergey
doaj +1 more source
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Worker exposure to ultrafine particles during carbon black treatment
Medycyna Pracy, 2015 Background: The aim of the project was to assess the exposure of workers to ultrafine particles released during handling and packing of carbon black.
Urszula Mikołajczyk +2 more
doaj +1 more source
Packing and covering in higher dimensions
, 2022 The present work surveys problems in $n$-dimensional space with $n$ large. Early development in the study of packing and covering in high dimensions was motivated by the geometry of numbers. Subsequent results, such as the discovery of the Leech lattice and the linear programming bound, which culminated in the recent solution of the sphere packing ...
openaire +2 more sources
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
A new sphere packing in 20 dimensions
Inventiones Mathematicae, 1995 The problem of constructing dense sphere packings in \(\mathbb{R}^n\) dates back to the famous Kepler conjecture in 1611 \((n = 3)\), reformulated by Hilbert in 1901 (18th Problem, part 3), and Gauß (proof for lattice packings, \(n = 3)\). Major progress for `medium' dimensions \((9 \leq n \leq 48)\) was made by Leech, Coxeter, Conway, Sloane, Todd ...
openaire +3 more sources
FEBS Letters, EarlyView.Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii +8 more
wiley +1 more source
The Third Dimension of the Magdouh Mosaic in Antioch
Journal of Mosaic Research, 2019 This study investigates the complex geometry of the pattern of circles in the Magdouh Mosaic, which dates to between the ffth and sixth centuries, found in Antioch-on-the-Orontes (modern Antakya, Turkey). The mosaic has a complex pattern that is composed
Hakan HİSARLIGİL +1 more
doaj +1 more source