Results 101 to 110 of about 325,035 (334)
A working model for cytoplasmic assembly of H/ACA snoRNPs
FEBS Letters, EarlyView.Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley +1 more source
A study on exponential-size neighborhoods for the bin packing problem with conflicts
, 2017 We propose an iterated local search based on several classes of local and large neighborhoods for the bin packing problem with conflicts. This problem, which combines the characteristics of both bin packing and vertex coloring, arises in various ...
Capua, Renatha +3 more
core +1 more source
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Melting of hexagonal skyrmion states in chiral magnets
New Journal of Physics, 2013 Skyrmions are spiral structures observed in thin films of certain magnetic materials (Uchida et al 2006 Science 311 359–61). Of the phases allowed by the crystalline symmetries of these materials (Yi et al 2009 Phys. Rev.
M C Ambrose, R L Stamps
doaj +1 more source
Journal of Lipid Research, 2001 It has been demonstrated in animal studies that polyunsaturated fatty acids (PUFA) prevent ischemia-induced malignant ventricular arrhythmias, a major cause of sudden cardiac death in humans.
Eric M. Pound, Jing X. Kang, A. Leaf
doaj +1 more source
A new perspective on the analysis of helix-helix packing preferences in globular proteins
, 2003 For many years it had been believed that steric compatibility of helix interfaces could be the source of the observed preference for particular angles between neighbouring helices as emerging from statistical analysis of protein databanks.
Seno, F., Trovato, A.
core +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Generic zero-Hausdorff and one-packing spectral measures [PDF]
, 2021 Silas L. Carvalho, César R. de Oliveira
openalex +1 more source
What is isostructurality? Questions on the definition
IUCrJInvestigation of isostructurality leads to a deeper understanding of close-packing principles and contributes to the ability of crystal engineering. A given packing motif may tolerate small molecular changes within a limit.
Petra Bombicz
doaj +1 more source
Shear modulus and Dilatancy Softening in Granular Packings above Jamming
, 2014 We investigate experimentally the mechanical response of a monolayer of bi-disperse frictional grains to an inhomogeneous shear perturbation across the jamming transition.
Coulais, Corentin +2 more
core +3 more sources