Results 101 to 110 of about 331,594 (334)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A new perspective on the analysis of helix-helix packing preferences in globular proteins
, 2003 For many years it had been believed that steric compatibility of helix interfaces could be the source of the observed preference for particular angles between neighbouring helices as emerging from statistical analysis of protein databanks.
Seno, F., Trovato, A.
core +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Melting of hexagonal skyrmion states in chiral magnets
New Journal of Physics, 2013 Skyrmions are spiral structures observed in thin films of certain magnetic materials (Uchida et al 2006 Science 311 359–61). Of the phases allowed by the crystalline symmetries of these materials (Yi et al 2009 Phys. Rev.
M C Ambrose, R L Stamps
doaj +1 more source
Journal of Lipid Research, 2001 It has been demonstrated in animal studies that polyunsaturated fatty acids (PUFA) prevent ischemia-induced malignant ventricular arrhythmias, a major cause of sudden cardiac death in humans.
Eric M. Pound, Jing X. Kang, A. Leaf
doaj +1 more source
MARKET POWER IN BEEF PACKING: FEEDLOT "CAPTURE" AND ITS CAUSES [PDF]
Concentration in the beef packing industry has been rising for the past 25 years. Many studies of market power in beef packing are based on the conjectural variations framework, which depends on accurate estimates of packer input and processing costs. We
Bailey, DeeVon +2 more
core +1 more source
A study on exponential-size neighborhoods for the bin packing problem with conflicts
, 2017 We propose an iterated local search based on several classes of local and large neighborhoods for the bin packing problem with conflicts. This problem, which combines the characteristics of both bin packing and vertex coloring, arises in various ...
Capua, Renatha +3 more
core +1 more source
The Hausdorff and packing measure of some digital expansions [PDF]
, 2022 Daniel Ingebretson
openalex +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
What is isostructurality? Questions on the definition
IUCrJInvestigation of isostructurality leads to a deeper understanding of close-packing principles and contributes to the ability of crystal engineering. A given packing motif may tolerate small molecular changes within a limit.
Petra Bombicz
doaj +1 more source